Modeling a measurement-device-independent quantum key distribution system

We present a detailed description of a widely applicable mathematical model for quantum key distribution (QKD) systems implementing the measurement-device-independent (MDI) protocol. The model is tested by comparing its predictions with data taken using a proof-of-principle, time-bin qubit-based QKD system in a secure laboratory environment (i.e. in a setting in which eavesdropping can be excluded). The good agreement between the predictions and the experimental data allows the model to be used to optimize mean photon numbers per attenuated laser pulse, which are used to encode quantum bits. This in turn allows optimization of secret key rates of existing MDI-QKD systems, identification of rate-limiting components, and projection of future performance. In addition, we also performed measurements over deployed fiber, showing that our system's performance is not affected by environment-induced perturbations.Comment: 21 pages, 7 figure

NKT cells inhibit antigen-specific effector CD8 T cell induction to skin viral proteins

Type 1 diabetes (T1D) results from autoimmune destruction of insulin-producing pancreatic β cells. Therapies need to incorporate strategies to overcome the genetic defects that impair induction or maintenance of peripheral T-cell tolerance and contribute to disease development. We tested whether the enforced expression of an islet autoantigen in antigen-presenting cells (APC) counteracted peripheral T-cell tolerance defects in autoimmune-prone NOD mice. We observed that insulin-specific CD8(+) T cells transferred to mice in which proinsulin was transgenically expressed in APCs underwent several rounds of division and the majority were deleted. Residual insulin-specific CD8(+) T cells were rendered unresponsive and this was associated with TCR downregulation, loss of tetramer binding and expression of a range of co-inhibitory molecules. Notably, accumulation and effector differentiation of insulin-specific CD8(+) T cells in pancreatic lymph nodes was prominent in non-transgenic recipients but blocked by transgenic proinsulin expression. This shift from T-cell priming to T-cell tolerance exemplifies the tolerogenic capacity of autoantigen expression by APC and the capacity to overcome genetic tolerance defects

Microcystic, Elongated, and Fragmented (MELF) Pattern Invasion in Ovarian Endometrioid Carcinoma: Immunohistochemical Profile and Prognostic Implications

BACKGROUND •Microcystic, Elongated and Fragmented (MELF) is a well-recognized pattern of uterine endometrioid carcinoma (UEC) associated with lymphovascular space invasion and occult lymph node metastasis •MELF in UEC may be seen with Lynch Syndrome •MELF in UEC is hypothesized to be histologic evidence of an epithelial mesenchymal transition •MELF pattern invasion in ovarian endometrioid carcinoma (OEC) was first described at USCAP 2015 • Current study evaluates MELF in OEC for •Prognostic implications •Immunohistochemical (IHC) profile related to •Lynch Syndrome •Epithelial mesenchymal transition DESIGN •42 consecutive cases of OEC without concurrent UEC (1996-2014) evaluated by 2 pathologists •MELF defined as at least three glands fulfilling histologic criteria •32 cases had blocks available for staining •MLH1, PMS2, MSH2 and MSH6 for mismatch repair (MMR) protein expression •Graded as “retained” or “lost” •β-catenin, e-cadherin, CK19 and cyclin D1 for evidence of epithelial mesenchymal transition •Graded as “rare” (75% cells stain) •Retrospective chart review of clinical and demographic features and overall survival •Data analyzed using Fisher exact test analysis •Survival analyzed using Kaplan-Meier metho

Connick v. Thompson: Sacrificing Deterrence and Reparations in the Name of Avoiding Respondeat Superior Liability

Death is the ultimate punishment because of its finality; once it is carried out, it can never be revoked. John Thompson came close to this ultimate punishment because a prosecutor failed to turn over exculpatory evidence under the principles that the U.S. Supreme Court enunciated in Brady v. Maryland. In Connick v. Thompson, the Court overturned Thompson’s $14 million award for spending eighteen years in prison (fourteen of those on death row) because previous Brady violations by the Orleans District Attorney’s Office were not enough to put the district attorney on notice regarding the need for further training on Brady’s principles and because the need for training was not so obvious that the district attorney’s office could be held liable under the failure-to-train theory. The Court’s holding is detrimental because an entire district attorney’s office may now be shielded from civil liability in the event of a Brady violation and because individuals like Thompson will have no recourse for spending time in prison due to prosecutorial misconduct. The Court’s holding discourages prosecutors from turning over exculpatory evidence, thus reducing prosecutorial accountability, and runs counter to the deeply rooted American principle that every person has the right to a fair trial

The Future of Direct Potable Reuse in California: Overcoming Public Acceptance Barriers

Due to the water shortages, population growth, and competing demands for water in California, the possibility of incorporating direct potable reuse technology in the state’s water supply portfolio is being considered by various water resource providers. This paper focuses on public acceptance challenges that may be encountered. By evaluating best practices employed by six different potable water reuse case studies, recommendations for future direct potable reuse projects are developed. It is recommended that future project proponents plan early and conduct public opinion surveys regarding this type of technology, develop and implement public outreach and education plans that include best practices defined in the case study analysis, and develop outreach and education materials that meet the interests of various audiences. Specific practices that should be considered include: educating the public about where existing supply sources come from when describing the need for DPR technology, garnering support from health professionals and local politicians, targeting outreach efforts to groups of people that may be wary of this type of technology, and offering public tours of advanced water purification facilities

Rapid detection of BRCA1/2 recurrent mutations in Chinese breast and ovarian cancer patients with multiplex SNaPshot genotyping panels.

BRCA1/2 mutations are significant risk factors for hereditary breast and ovarian cancer (HBOC), its mutation frequency in HBOC of Chinese ethnicity is around 9%, in which nearly half are recurrent mutations. In Hong Kong and China, genetic testing and counseling are not as common as in the West. To reduce the barrier of testing, a multiplex SNaPshot genotyping panel that targeted 25 Chinese BRCA1/2 mutation hotspots was developed, and its feasibility was evaluated in a local cohort of 441 breast and 155 ovarian cancer patients. For those who tested negative, they were then subjected to full-gene testing with next-generation sequencing (NGS). BRCA mutation prevalence in this cohort was 8.05% and the yield of the recurrent panel was 3.52%, identifying over 40% of the mutation carriers. Moreover, from 79 Chinese breast cancer cases recruited overseas, 2 recurrent mutations and one novel BRCA2 mutation were detected by the panel and NGS respectively. The developed genotyping panel showed to be an easy-to-perform and more affordable testing tool that can provide important contributions to improve the healthcare of Chinese women with cancer as well as family members that harbor high risk mutations for HBOC