Analysing attempts to support outdoor learning in Scottish schools

The new ‘Curriculum for Excellence’ in Scotland outlines a policy vision of a more integrated and holistic form of education; a commitment which offers considerable prospects for increased levels of outdoor learning in schools (Learning and Teaching Scotland, 2010). With reference to Fullan’s theorizing on achieving educational change, we investigated four main implementation areas, namely: policy aims, partnerships arrangements and associated professionalism and sustainability issues. We collected evidence through a series of sixteen semi-structured interviews with key stakeholders at national, local authority and school level. Despite increased agreement on aims, we found that improving the frequency and quality of outdoor learning in schools was adversely influenced by the patchwork nature of partnership support at national and local authority levels. This has curtailed the prioritizing of outdoor learning in schools and of teachers being supported when trying to make use of their increased curriculum decision-making responsibilities. Thus, we found only limited evidence of policy-related innovation and considerable evidence of policy stasis. As such, building national capacity is proving difficult. We conclude that further research on how some atypical schools have managed to develop their programmes offers the best prospects for understanding the complexities of achieving greater levels of outdoor learning

Solution structure of a repeated unit of the ABA-1 nematode polyprotein allergen of ascaris reveals a novel fold and two discrete lipid-binding sites

Parasitic nematode worms cause serious health problems in humans and other animals. They can induce allergic-type immune responses, which can be harmful but may at the same time protect against the infections. Allergens are proteins that trigger allergic reactions and these parasites produce a type that is confined to nematodes, the nematode polyprotein allergens (NPAs). These are synthesized as large precursor proteins comprising repeating units of similar amino acid sequence that are subsequently cleaved into multiple copies of the allergen protein. NPAs bind small lipids such as fatty acids and retinol (Vitamin A) and probably transport these sensitive and insoluble compounds between the tissues of the worms. Nematodes cannot synthesize these lipids, so NPAs may also be crucial for extracting nutrients from their hosts. They may also be involved in altering immune responses by controlling the lipids by which the immune and inflammatory cells communicate. We describe the molecular structure of one unit of an NPA, the well-known ABA-1 allergen of Ascaris and find its structure to be of a type not previously found for lipid-binding proteins, and we describe the unusual sites where lipids bind within this structur

The outcomes of educational welfare officer contact in England

The key purpose of educational welfare officers in England is to support students and parents to maximise educational opportunities for young people. However more is known about their role in relation to school attendance than in relation to pupils’ educational outcomes. Using the Longitudinal Survey of Young People in England (LSYPE), this paper investigates the characteristics of teenagers who received educational welfare contact because of their behaviour between 2004 and 2006. With observational data it is often difficult to isolate respondents exposed to a particular intervention or ‘treatment’, because of non-random allocation. We address this using inverse-probability-weighted regression adjustment (IPWRA) to estimate more accurately the effect of educational welfare contact on outcomes of educational achievement and aspiration. Our findings indicate that young people who had educational welfare contact because of their behaviour were less likely to apply to university, less confident in university acceptance if they applied and had lower odds of achieving five General Certificate of Secondary Education at grades A*–C, the government benchmark for education achievement at age 16. We discuss the limitations we face and implications of these findings for future research

Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development.

BACKGROUND: We present the genome sequence of the tammar wallaby, Macropus eugenii, which is a member of the kangaroo family and the first representative of the iconic hopping mammals that symbolize Australia to be sequenced. The tammar has many unusual biological characteristics, including the longest period of embryonic diapause of any mammal, extremely synchronized seasonal breeding and prolonged and sophisticated lactation within a well-defined pouch. Like other marsupials, it gives birth to highly altricial young, and has a small number of very large chromosomes, making it a valuable model for genomics, reproduction and development. RESULTS: The genome has been sequenced to 2 × coverage using Sanger sequencing, enhanced with additional next generation sequencing and the integration of extensive physical and linkage maps to build the genome assembly. We also sequenced the tammar transcriptome across many tissues and developmental time points. Our analyses of these data shed light on mammalian reproduction, development and genome evolution: there is innovation in reproductive and lactational genes, rapid evolution of germ cell genes, and incomplete, locus-specific X inactivation. We also observe novel retrotransposons and a highly rearranged major histocompatibility complex, with many class I genes located outside the complex. Novel microRNAs in the tammar HOX clusters uncover new potential mammalian HOX regulatory elements. CONCLUSIONS: Analyses of these resources enhance our understanding of marsupial gene evolution, identify marsupial-specific conserved non-coding elements and critical genes across a range of biological systems, including reproduction, development and immunity, and provide new insight into marsupial and mammalian biology and genome evolution

Brief Report: Out of Sight Out of Mind - Preventable Childhood Kidney Disease in the Far North

APSGN is an immune-mediated kidney disease that occurs after a Streptococcus pyogenes skin or throat infection in children and contributes to chronic kidney disease later in life. It is a disease of poverty and regrettably common in Aboriginal and Torres Strait Islander children. There have been seven documented APSGN outbreaks across Far North Queensland in the last nine years. Despite this disease being notifiable in both Western Australia and the Northern Territory, Queensland is yet to acknowledge the importance of early notification in the management of APSGN. Notification-driven publication of APSGN incidence should help raise its profile and stimulate better public health policy

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy