WHY I BELIEVE IN MONSTERS (AND YOU SHOULD TOO)

According to Kaplan’s bidimensional theory of demonstratives, the descriptive content of any indexical term (and the sentences they appear in) is only employed to determine its reference in any possible world rigidly but cannot be expressed by the sentence’s truth conditions. Kaplan then argues that an indexical sentence’s informativeness depends on what he calls its character, a property of the context that relates a particular context to a concrete content, but it cannot be a part of the proposition the sentence entertains (its content), primarily given the logical inconsistencies the opposite would show in the theory of conditionals and counterfactuals. I agree with Kaplan that indexicals should not be considered disguised descriptions. Nevertheless, I believe that their content is informative and, therefore, part of the proposition these sentences express, even though that implies accepting the existence of content shifting operators within the same context --what Kaplan dubbed monsters. This paper, therefore, presents an alternative account to indexical terms and sentences employing the Interactive Theory introduced in Colomina-Alminana (2022). This approach considers that the meaning of any sentence, the proposition it expresses, depends upon three interrelated factors: the speaker’s intentions when uttering, the audience’s potential uptakes of such statement, and the conventions established by the speech community both speaker and audience belong, or the linguistic interaction takes place. The critical element is the so-called speaker\u27s point of view, an objective perspectival networking background that allows lexical and syntactic mechanisms to trigger and update potential conceptual presuppositional content shared by both speaker and audience and whose existence is prior to any context and circumstances

Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study

NRPT is a combination of nicotinamide riboside (NR), a nicotinamide adenine dinucleotide (NAD⁺) precursor vitamin found in milk, and pterostilbene (PT), a polyphenol found in blueberries. Here, we report this first-in-humans clinical trial designed to assess the safety and efficacy of a repeat dose of NRPT (commercially known as Basis). NRPT was evaluated in a randomized, double-blind, and placebo-controlled study in a population of 120 healthy adults between the ages of 60 and 80 years. The study consisted of three treatment arms: placebo, recommended dose of NRPT (NRPT 1X), and double dose of NRPT (NRPT 2X). All subjects took their blinded supplement daily for eight weeks. Analysis of NAD⁺ in whole blood demonstrated that NRPT significantly increases the concentration of NAD⁺ in a dose-dependent manner. NAD⁺ levels increased by approximately 40% in the NRPT 1X group and approximately 90% in the NRPT 2X group after 4 weeks as compared to placebo and baseline. Furthermore, this significant increase in NAD⁺ levels was sustained throughout the entire 8-week trial. NAD⁺ levels did not increase for the placebo group during the trial. No serious adverse events were reported in this study. This study shows that a repeat dose of NRPT is a safe and effective way to increase NAD⁺ levels sustainably