PREPARATION AND INVITIGATION OF DIAZIPENE, OXAZIPEN COMPOUNDS THROUGH CONDESATION REACTION

This paper involves synthesis of p-N,N-dimethylaminobenzylideneareneamines(Schiff bases),Compounds[N2-N17]were synthesized by condensation of  p-N,N-dimethylaminobenzaldehyde with different primary aromatic amines,which reacted with phthalic anhydride to produce other sixteen oxazepine compounds [N34-N49],which reacted whith various primary aromatic amines to produce five derivatives of diazepine compounds [N35, N38, N41, N46, N48] .Keyword: sevene ring, diels-alder ,condensation reactio

The double infection diagnosis, fungal and insect on date palm offshoot Phoenix dactylifera with treatment pesticides and practical technique

This study was carried out several times in the field during September 2019 in Baghdad Governorate and these data are the results of the last observation in the field. Cultivation of palm offshoots of the yellow Barhi variety, the first strain in quality and production were the number offshoots was 75, 25-40 kg weighed, which were divided into three groups, each one was 25 offshoots. The first group was subjected to a comparison treatment (control), while in the second group the offshoots were treated by immersion before planting with a solution containing a systemic fungicide (Biltanol) at a concentration of 1 mL L-1, and then immersed in a solution containing a type of insecticide (Cinfidor) at a concentration of 1 mL L-1 and then planted and controlled after 2 months of planting by the same pesticides and with the same concentration. In the case of third group, it was controlled after 2 months of planting with the same pesticides above, and after a year of planting and services. A success rate was obtained as 60%, 100% and 96% in the first, second and third treatment consecutively. The insect was diagnosed as a red scale parlatotoria Blanchardi, while the fungus was diagnosed in the laboratory by a direct examination and using a light microscope as Fusarium oxysporium. The aim of the study was to reduce the number of dead offshoots after planting in the field

A strategic framework for synergizing managed entry agreement efforts to access pharmaceutical products in Saudi Arabia-results from a multi-stakeholder workshop

Managed entry agreements (MEAs) between manufacturers and healthcare payers allow health systems to maximize patients' access to treatments while maintaining financial sustainability. However, to work efficiently, MEAs need to be integrated into a country's formal pricing, reimbursement, and market access processes. This study proposes a country-specific MEA framework for pharmaceutical products and sheds light on the key enablers of optimal implementation of MEAs in Saudi Arabia. This mixed-methods study was conducted through secondary data collection derived from systematic literature search followed by a half-day multi-stakeholder workshop hosted in Riyadh, Saudi Arabia including representatives from different governmental, quasi-governmental, and private sectors, all of whom had a job role related to pharmaceutical pricing, reimbursement, and market access. A predefined and validated set of questions was used to guide the workshop discussion with props and prompts to elicit more insights on MEAs design and framework from the participants. The workshop discussion and interactions were digitally recorded to enable verbatim transcription, followed by a thematic analysis. Ten themes emerged from the workshop discussion with majority guided the framework design: (1) access to innovative medications; (2) stakeholder views about MEAs; (3) early dialogue; (4) prioritization of MEAs for pharmaceutical products; (5) the regulatory landscape; (6) designing a technical framework for MEAs; (7) innovative payment models; (8) health system governance; (9) challenges for successful implementation; and (10) stakeholder engagement. In Saudi Arabia, MEAs are perceived as strategic levers to enable health system to navigate the access paradox, particularly for innovative and high-cost therapies. Nevertheless, having in place a robust Saudi-specific framework and anchored regulations and policies is essential to ensure that MEAs enhance-rather than compromise-access, sustainability, and equity. As therapies grow more complex, Saudi Arabia must adopt agile, evidence-adaptive MEAs policy and structure to remain fit for purpose

Navigating the First Year: A Proposed E-Coaching Model to Ease Uncertainty for Saudi Students in University to Foster Academic and Social Engagement

A thesis submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the School of Computing, Engineering and Mathematical Sciences, La Trobe University, Victoria, Australia.</p

Effect of discontinuous curing and ambient temperature on the compressive strength development of fly ash based Geopolymer concrete

In the current study, 6 mixtures of Geopolymer concrete have been studied. The effect of discontinuous curing in oven and in atmosphere ambient temperature has been inspected by exposing the Geopolymer concrete specimens to temperature in the oven for few hours then stopping the oven to let it cool down to the ambient temperature. The compressive strength test of 100x200 mm cylindrical specimens for each mixture has been performed at different ages. It was found that the ambient temperature has vast effect on the compressive strength of the Geopolymer concrete in discontinuous curing. Discontinuous curing saves energy and can be a good replacement to the continuous curing when the ambient temperature is 40°C or more. Specimens that were cured continuously in ambient temperature of 43°C has resulted in compressive strength of 23 MPa at age of 40 days; to enhance the compressive strength, it is advised to impose few hours of discontinuous oven curing. It was also found that the rest period (starts when pouring concrete in forms and ends when imposing oven curing to the Geopolymer) has a positive influence on the compressive strength of Geopolymer concrete, but when no rest period is allowed, the later ages compressive strength is remarkably higher

Effect of discontinuous curing and ambient temperature on the compressive strength development of fly ash based Geopolymer concrete

In the current study, 6 mixtures of Geopolymer concrete have been studied. The effect of discontinuous curing in oven and in atmosphere ambient temperature has been inspected by exposing the Geopolymer concrete specimens to temperature in the oven for few hours then stopping the oven to let it cool down to the ambient temperature. The compressive strength test of 100x200 mm cylindrical specimens for each mixture has been performed at different ages. It was found that the ambient temperature has vast effect on the compressive strength of the Geopolymer concrete in discontinuous curing. Discontinuous curing saves energy and can be a good replacement to the continuous curing when the ambient temperature is 40°C or more. Specimens that were cured continuously in ambient temperature of 43°C has resulted in compressive strength of 23 MPa at age of 40 days; to enhance the compressive strength, it is advised to impose few hours of discontinuous oven curing. It was also found that the rest period (starts when pouring concrete in forms and ends when imposing oven curing to the Geopolymer) has a positive influence on the compressive strength of Geopolymer concrete, but when no rest period is allowed, the later ages compressive strength is remarkably higher

Endoscopic management of limy bile syndrome presenting with obstructive jaundice

Limy bile syndrome is a rare entity in which there is an excessive precipitation of calcium salts, mainly calcium carbonate in the gallbladder (GB) and to a rare extent in the common bile duct (CBD), making it radiopaque in plain radiographs. Laparoscopic cholecystectomy is safe and effective in patients with limy bile confined to the GB. However, for patients with an extension to the CBD, bile duct exploration with a T-tube placement, endoscopic naso-billiary drainage or endoscopic sphincterotomy (EST) may be warranted. We report a case of limy bile syndrome associated with obstructive jaundice in a young female patient. She was managed successfully with EST followed by laparoscopic cholecystectomy.</jats:p

Low Velocity Impact Response of Reinforced Concrete Flat Slabs

Background Dimensions of the reference concrete slab are 1950x1950x100 mm subjected to drop-weight impact loading. Objective A comprehensive parametric study was performed to examine the influence of many parameters on the RC slabs. Method From the viewpoint of cost and time savings, a three-dimensional finite element is a very good tool to predict the real behavior of the structural elements. Result and Discussion Results showed that the use of CFRP strips enhance the impact behavior of the slab. Contrarily, the existence of opening led to a dramatic decrease in the dynamic capacity of RC slabs with stress concentration around the openings. Furthermore, changing the shape of the impactor showed a significant effect on the peak impact load as well as the ultimate deflection at impact instant. Conclusion In the scope of this paper, the response of RC slab with top and bottom reinforcements exposed to drop-weight impact loading was inspected. Time histories of impact loads and deflections were presented in detail based on ABAQUS/ Explicit analysis. The findings presented in this paper can be presented as follows: 1. The FE models show a good correlation with the experimental data. Consequently, the proposed finite element models are efficient and economical tool to explorer the effect of many parameters on the performance of RC slabs subjected to drop-weight impact load. 2. The numerical simulation confirmed that using externally bonded CFRP strips has more influence on the peak deflection of the reinforced concrete slab than the recorded impact force. 3. Comparing to the flat shape of the impactor, the hemispherical and curved shape impactor can produce large penetration depth at the impact zone with higher plastic deformations in the concrete slab. However, the flat impactor produced higher deflection at the impact instant. 4. As the radius of the impactor increases, both the duration time and the peak impact force are increased. This is because of the higher contact area was obtained when the flat impactor (infinity radius of curvature) was used as compared to other impactors. 5. Due to decreases in RC slab stiffness, the presence of openings (regardless of their shape) has considerably increased deformations in concrete especially around perimeter of the openings extended to the nearby support. 6. It has been found that the eccentric impact loading causes higher plastic deformations than the concentric one. </jats:sec

Spontaneous Splenic Rupture following Colorectal Surgery and Hemodialysis

Atraumatic splenic rupture is rarely encountered in clinical practice compared to traumatic rupture. General risk factors include hematological, infectious, or malignant splenic diseases, uremic coagulopathy, use of heparin, hypertension, and immune-compromised status. Spontaneous splenic rupture following colorectal surgery has never been reported. Maintaining a high index of suspicion in patients presenting with left upper quadrant pain and tenderness is crucial. Diagnosis can be made with the aid of an ultrasound or CT scan. The management plan should be tailored to the patient’s clinical conditions. The authors present a case of spontaneous splenic rupture in a patient following colectomy for cancer and undergoing postoperative hemodialysis and discuss the possible etiological factors.</jats:p