Assessing the Effects of Using a Ureteral Access Sheath on Kidney Injury in Retrograde Intrarenal Surgery with KIM-1 and NGAL Biomarkers in Urine: A Prospective Cohort Study

Objective: This study aimed to investigate the effects of ureteral access sheath (UAS) use in patients undergoing retrograde intrarenal surgery (RIRS) due to kidney stones on postoperative early kidney injury development using urine kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) measurements. Materials and Methods: Thirty patients using UAS (UAS group) and 30 not using UAS (non-UAS group), for whom RIRS was planned, and 30 healthy controls (control group) were included between January and June. Blood urea nitrogen and creatinine in the blood and KIM-1 and NGAL in the urine at the pre-operative and postoperative 24th hours and KIM-1 and NGAL at the postoperative 4th and 24th hours were studied. The same biomarkers were analyzed once in the control group. During follow-up, KIM-1 and NGAL were measured using the enzyme-linked immunosorbent assay method within 6 months. Results: There was no significant difference between the pre-operative KIM-1 and NGAL values and the postoperative 24-h KIM-1 and NGAL values in the UAS group (p>0.05), whereas there was a significant difference in the non-UAS group (p<0.05). The postoperative 24-h KIM-1 and NGAL values were significantly higher in the UAS group than in the non-UAS group (p<0.05). Conclusion: It was determined that more kidney injury developed in the non-UAS group UAS than in the UAS group, especially at the postoperative 24th hour. The use of UAS in RIRS is effective in preventing the development of potential kidney injury

Evaluation of Risk Factors in Children with Hypospadias

Objective: Hypospadias is one of the most common congenital defects in boys. Multifactorial factors such as genetic predisposition and environmental factors play a role in the etiology of hypospadias. In this study, we investigated the risk factors of patients diagnosed with hypospadias. Materials and Methods: Thirty-six patients who applied to the pediatric endocrinology and urology outpatient clinics with the diagnosis of hypospadias were evaluated retrospectively. Risk factors were evaluated by recording the parental ages, exposure to environmental factors, the maternal BMI, history of pregnancy, drug use, and the father’s fertility status. Results: The mean age of the patients was 3.5 ± 2 years. The patients had anterior (n:27 : 75%), middle (midshaft) (n:8 ; 22.2%), and posterior (n:1 ; 2.8%) hypospadias. The mean body mass index (BMI) of the mothers was 24 ± 4.1 kg/m2. Eight (22.2%) mothers were overweight and six (16.6%) mothers were obese. There was a history of hypospadias in the family of 4 (11%) patients. Conclusion: Although combinations of environmental and genetic factors play a role in the etiology of hypospadias, many unexplained factors are responsible for this disease.</jats:p

Management of Giant Retroperitoneal Liposarcoma: A Case Report

Retroperitoneal liposarcoma (RPLS) is a rare tumor. Early diagnosis and treatment are difficult due to absence of specific clinical presentations. We report a case of a 66-years-old woman who succesfully underwent complete surgical resection for a giant retroperitoneal liposarcoma. The complete surgical resection is the most important predictor of local recurrence and overall survival. We believe that complete surgical resection involving adjacent organs is a curative treatment to increase overall survival, especially in the presence of invasion of large tumors.</jats:p

THE ASSOCIATION BETWEEN SERUM OSTEOPONTIN LEVELS AND OPN ALA 250 POLYMORPHISM IN UROLITHIASIS

WOS: 000308488204191