Generalization of Fuzzy Soft <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1"> <mrow> <mtext>BCK</mtext> </mrow> <mo>/</mo> <mrow> <mtext>BCI</mtext> </mrow> </math>-Algebras

In this paper, the notions of ∈ , ∈ ∨ q -fuzzy soft BCK / BCI -algebras and ∈ , ∈ ∨ q -fuzzy soft sub- BCK / BCI -algebras are introduced, and related properties are investigated. Furthermore, relations between fuzzy soft BCK / BCI -algebras and ∈ , ∈ ∨ q -fuzzy soft BCK / BCI -algebras are displayed. Moreover, conditions for an ∈ , ∈ ∨ q -fuzzy soft BCK / BCI -algebra to be a fuzzy soft BCK / BCI -algebra are provided. Also, the union, the extended intersection, and the “AND”-operation of two ∈ , ∈ ∨ q -fuzzy soft (sub-) BCK / BCI -algebras are discussed, and a characterization of an ∈ , ∈ ∨ q -fuzzy soft BCK / BCI -algebra is established.</jats:p

Generalization of Fuzzy Soft BCK/BCI-Algebras

In this paper, the notions of ∈,∈∨q-fuzzy soft BCK/BCI-algebras and ∈,∈∨q-fuzzy soft sub-BCK/BCI-algebras are introduced, and related properties are investigated. Furthermore, relations between fuzzy soft BCK/BCI-algebras and ∈,∈∨q-fuzzy soft BCK/BCI-algebras are displayed. Moreover, conditions for an ∈,∈∨q-fuzzy soft BCK/BCI-algebra to be a fuzzy soft BCK/BCI-algebra are provided. Also, the union, the extended intersection, and the “AND”-operation of two ∈,∈∨q-fuzzy soft (sub-)BCK/BCI-algebras are discussed, and a characterization of an ∈,∈∨q-fuzzy soft BCK/BCI-algebra is established

Fuzzy Set Theoretic Approach to Generalized Ideals in BCK/BCI-Algebras

This paper deals with the study of generalizations of fuzzy subalgebras and fuzzy ideals in BCK/BCI-algebras. In fact, the notions of ∈ , ∈ ∨ κ ~ ∗ , q κ ~ -fuzzy subalgebras, ∈ , ∈ ∨ κ ~ ∗ , q κ ~ -fuzzy ideals, and ∈ ∨ κ ~ ∗ , q κ ~ , ∈ ∨ κ ~ ∗ , q κ ~ -fuzzy ideals in BCK/BCI-algebras are introduced. Some examples are provided to demonstrate the logic of the concepts used in this paper. Moreover, some characterizations of these notions are discussed. In addition, the concept of ∈ , ∈ ∨ κ ~ ∗ , q κ ~ -fuzzy commutative ideals is introduced, and several significant characteristics are discussed. It is shown that for a BCK-algebra A , every ∈ , ∈ ∨ κ ~ ∗ , q κ ~ -commutative ideal of a BCK-algebra is an ∈ , ∈ ∨ κ ~ ∗ , q κ ~ -fuzzy ideal, but the converse does not hold in general; a counter example is constructed.</jats:p

Fuzzy Set Theoretic Approach to Generalized Ideals in BCK/BCI-Algebras

This paper deals with the study of generalizations of fuzzy subalgebras and fuzzy ideals in BCK/BCI-algebras. In fact, the notions of ∈,∈∨κ~∗,qκ~-fuzzy subalgebras, ∈,∈∨κ~∗,qκ~-fuzzy ideals, and ∈∨κ~∗,qκ~,∈∨κ~∗,qκ~-fuzzy ideals in BCK/BCI-algebras are introduced. Some examples are provided to demonstrate the logic of the concepts used in this paper. Moreover, some characterizations of these notions are discussed. In addition, the concept of ∈,∈∨κ~∗,qκ~-fuzzy commutative ideals is introduced, and several significant characteristics are discussed. It is shown that for a BCK-algebra A, every ∈,∈∨κ~∗,qκ~-commutative ideal of a BCK-algebra is an ∈,∈∨κ~∗,qκ~-fuzzy ideal, but the converse does not hold in general; a counter example is constructed

Novel Association of Thrombophilic PROS1, PROC and CPB2 Genes Polymorphisms with Recurrent Spontaneous Miscarriage Women in Jordan

Recurrent spontaneous miscarriage (RSM) is a gynecological complication has multifactorial etiologies including genetic factors. However, role of thrombophilic gene polymorphisms in RSA among Jordanian women is limited. This study explores the association between polymorphisms in SERPINC1, PROC, PROS1, PROZ, F5, F13A1 , and CPB2 and RSA risk in Jordanian pregnant women. Blood samples were taken from 188 women with recurrent spontaneous miscarriage (RSM) and 193 control subjects without a history of miscarriage. Genomic DNA was extracted and analyzed for polymorphisms of thrombophilic genes using Kompetitive Allele Specific Polymerase Chain Reaction. The SNPStats tool was used to assess haplotype, genotype, and allele frequencies, with chi-square (χ²) tests employed to evaluate statistical significance. A total of seven thrombophilic genes were analyzed. The rs8178607 polymorphism in PROS1 was significantly associated with RSA in Jordanian women under the allelic (OR = 2.06, p  = .014), codominant (OR = 2.05, p  = .021), dominant (OR = 1.27, p  = .015), and overdominant (OR = 1.91, p  = .03) genetic models. Additionally, significant associations in the recessive model were observed for the rs1799810 and the rs1926447 polymorphisms in PROC (OR = 1.66, p  = .038) and in CPB2 (OR = 1.89, p  = .046), respectively. Our data preliminary demonstrates that the rs8178607, rs1799810, and rs1926447 genotypes of PROS1, PROC, and CPB2 respectively , are associated with an increased risk of RSA among Jordanian pregnant women. Further investigations with larger cohorts and family-based analyses are essential to elucidate the genetic variation of biochemical pathways and mechanisms influences recurrent miscarriage susceptibility

Effectiveness of Aspartame on Insulin, Triglycerides, and Blood Glucose Concentration in adult type 2 diabetic patients

Background: Human beings have an attraction to sweet items: desserts, fruits, honey, etc., which stimulate the sense of taste. However, sweet things tend to have many calories, thus contributing to issues with obesity. Moreover, those with diabetes must strictly limit their consumption of sugar to maintain their blood glucose levels within acceptable limits. Artificial sweeteners contain substances from several distinct chemical classes. The effects of artificial sweeteners on clinically relevant outcomes such as insulin, blood glucose, and lipids have been incompletely studied. Objective: This study aims to assess the effects of artificial sweeteners on blood glucose, triglycerides, and insulin in healthy, non-diabetic, and diabetic type 2 patients. Material and method: Levels of glucose, triglycerides, and insulin in serum samples from 25 patients with confirmed Diabetic type 2 disease and 30 normal controls were determined at 30, and 60 after the ingestion of the drinks. Results: Levels of glucose, triglycerides, and insulin were notably higher in patients with diabetic Mellitus compared with the normal group. Both triglycerides and insulin (60 min) were elevated significantly above baseline after the intake of the artificial sweeteners in diabetic patients; however, values for all other conditions across time were very stable. Conclusion: There is no reason to suppose that a higher consumption would result in an elevation in these measures. Any noted insulin resistance linked to a high intake of artificial sweeteners is likely a function of the excess calories and processed ingredients often included within artificially sweetened food and beverage products. </jats:sec

New Sulfamethoxazole Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors: Design, Synthesis, Cytotoxic Activity and Molecular Modeling

In this study new sulphamethoxazole derivatives (S1–S4, S6–S12, and S14–S22) were designed and synthesized and their structures were fully characterized and validated using NMR, mass, and IR spectroscopy, as well as elemental analyses. All new derivatives (S1–S22) were assayed against human carbonic anhydrase (hCAs IX and XII) for their inhibitory activities. hCAs IX and XII were chosen due to the fact that CAIX expression is recognized as a hypoxia marker with a poor prognosis in breast cancer. When compared to Dorzolamide HCl as a standard reference, derivatives S2, S3, S8, S9, and S15 had the most effective inhibition with low IC50 values. The active compounds were further evaluated against hCAs I and II inhibitory activity and compounds S8, S9 and S15 showed the least inhibitory effect compared to the reference standard, acetazolamide, indicating that their effect in normal cells is the lowest. Cell viability tests for the selected compounds were carried out on MCF7 (normoxia and hypoxia) and on the normal breast cell line (MCF10a) with Staurosporine as a standard. The results showed that compound S15 had a highly potent cytotoxic effect. Furthermore, cell cycle analysis results showed that compound S15 triggered cell cycle arrest and apoptosis in G1/S of MCF7 cancer cells. Finally, molecular docking was performed to point out the possible explanation for the vital structural features and key-interactions exerted by our ligands with hCAs IX and XII that might share additional designs and highlight possible leads for a hopeful anticancer agent. Consequently, sulphamethoxazole Derivative S15 could be the potential lead for emerging selective cytotoxic compounds directing h CAs IX and XII