2,357 research outputs found

    Antioxidant and Ex Vivo Immune System Regulatory Properties of Boswellia serrata Extracts

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    Boswellia serrata (BS) is an important traditional medicinal plant that currently represents an interesting topic for pharmaceutical research since it possesses several pharmacological properties (e.g., anti-inflammatory, antimicrobial, and antitumour). The safety and versatility of this dietary supplement should allow for its use in numerous pathological conditions; however the quality of the extracts needs to be standardized to increase the clinical success rate resulting from its use. In the present study, different commercially available B. serrata extracts were employed to compare their AKBA content and in vitro antioxidant power. Furthermore, their ability to modulate the immune system regulatory properties was investigated. Our results showed that the AKBA content varied from 3.83 ± 0.10 to 0.03 ± 0.004%, with one sample in which it was not detectable. The highest antioxidant power and phenolic content were shown by the same extract, which also exhibited the highest AKBA concentration. Finally, the BS extracts showed the ability to influence the regulatory and effector T-cell compartments. Our results suggest that frankincense should be further investigated for its promising potentiality to modulate not only inflammation/oxidative stress but also immune dysregulation, but attention should be paid to the composition of the commercial extracts

    Development of a new Front End electronics in Silicon and Silicon-Germanium technology for the Resistive Plate Chamber detector for high rate experiments

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    The upgrade of the Resistive Plate Chamber (RPC) detector, in order to increase the detector rate capability and to be able to work efficiently in high rate environment, consists in the reduction of the operating voltage along with the detection of signals which are few hundred {\mu}V small. The approach chosen by this project to achieve this objective is to develop a new kind of Front End electronics which, thanks to a mixed technology in Silicon and Silicon-Germanium, enhance the detector performances increasing its rate capability. The Front End developed is composed by a preamplifier in Silicon BJT technology with a very low inner noise (1000 ee^{-} rms) and an amplification factor of 0.3-0.4 mV/fC and a new kind of discriminator in SiGe HJT technology which allows a minimum threshold of the order of 0.5 mV. The performances of this kind of Front End will be shown. The results are obtained by using the CERN H8 beamline with a full-size RPC chamber of 1 mm gas gap and 1.2 mm thickness of electrodes equipped with this kind of Front End electronics.Comment: 14th Workshop on Resistive Plate Chambers and Related Detectors 19-23 February, 2018 Puerto Vallarta, Jalisco state, Mexic

    Newsletter Serit n. 9 - Marzo 2014

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    La IVa Giornata Nazionale della Piattaforma Serit è stata dedicata ad esempi di “best practice” di progetti di ricerca, finanziati dal programma quadro FP7-Security Research Project, che si sono dimostrati “end-users friendly”. Il numero di questa newsletter offre una breve sintesi della giornata

    Newsletter Serit n. 4 - Aprile 2012

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    Presentazione delle proposte progettuali presentate nella 5°call Security FP7 che hanno avuto una valutazione positiva e che saranno, molto probabilmente, finanziate per portare avanti le attività di ricerca

    Newsletter Serit n. 6 - Gennaio 2013

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    In questo numero istituzione di un nuovo settore guida dedicato alla sicurezza per le smart city e annuncio della seconda edizione del Serit Award

    Newsletter Serit n. 5 - Luglio 2012

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    Numero dedicato alla Giornata Nazionale Serit che si è tenuta a Roma lo scorso 27 giugno 2012, in cui, dopo aver fatto il punto sulle attività realizzate dalla Piattaforma Serit nel corso dell’anno, si è passati a delineare i possibili obiettivi futuri, durante la tavola rotonda sul tema della ricerca sulla sicurezza in Italia in vista di Horizon 2020. Nel corso della giornata è stato assegnato al laboratorio Irea il Serit Award 2012 e presentato il secondo volume del libro Serit, uno strumento di riferimento per la comunità scientifica e tecnologica e per i decisori politici sui temi di ricerca in ambito sicurezza

    Newsletter Serit n. 7 - Aprile 2013

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    Descrizione delle missioni e degli obiettivi della Piattaforma Serit in vista di Horizon 2020. Annuncio della premiazione del II Award in occasionedella III Giornata Annuale della Piattaforma SERIT, l’ 8 luglio 2013 a Napoli
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