Directed motion of C60 on a graphene sheet subjected to a temperature gradient

Nonequilibrium molecular dynamics simulations is used to study the motion of a C60 molecule on a graphene sheet subjected to a temperature gradient. The C60 molecule is actuated and moves along the system while it just randomly dances along the perpendicular direction. Increasing the temperature gradient increases the directed velocity of C60. It is found that the free energy decreases as the C60 molecule moves toward the cold end. The driving mechanism based on the temperature gradient suggests the construction of nanoscale graphene-based motors

Energy-Aware Virtual Network Embedding Approach for Distributed Cloud

Network virtualization has caught the attention of many researchers in recent years. It facilitates the process of creating several virtual networks over a single physical network. Despite this advantage, however, network virtualization suffers from the problem of mapping virtual links and nodes to physical network in most efficient way. This problem is called virtual network embedding ("VNE"). Many researches have been proposed in an attempt to solve this problem, which have many optimization aspects, such as improving embedding strategies in a way that preserves energy, reducing embedding cost and increasing embedding revenue. Moreover, some researchers have extended their algorithms to be more compatible with the distributed clouds instead of a single infrastructure provider ("ISP"). This paper proposes energy aware particle swarm optimization algorithm for distributed clouds. This algorithm aims to partition each virtual network request ("VNR") to subgraphs, using the Heavy Clique Matching technique ("HCM") to generate a coarsened graph. Each coarsened node in the coarsened graph is assigned to a suitable data center ("DC"). Inside each DC, a modified particle swarm optimization algorithm is initiated to find the near optimal solution for the VNE problem. The proposed algorithm was tested and evaluated against existing algorithms using extensive simulations, which shows that the proposed algorithm outperforms other algorithms.Comment: International Journal of Advanced Computer Science and Applications(IJACSA

Could Upregulated Hsp70 Protein Compensate for the Hsp90-Silence-Induced Cell Death in Glioma Cells?

The molecular chaperone heat shock protein 90 alpha (Hsp90α) has been recognized in various tumours including glioma. This pilot study using a proteomic approach analyses the downstream effects of Hsp90 inhibition using 17-allylamino-17-demethoxygeldanamycin (17AAG) and a short hairpin RNA (shRNA) oligonucleotide targeting hsp90α (shhsp90α) in the U87-MG glioma cell line. Preliminary data coupled with bioinformatic analysis identified several known and unknown Hsp90 client proteins that demonstrated a change in their protein expression after Hsp90 inhibition, signifying an alteration in the canonical pathways of cell cycle progression, apoptosis, cell invasion, angiogenesis, and metastasis. Members of the glycolysis pathway were upregulated, demonstrating increased dependency on glycolysis for energy source by the treated glioma cells. Upregulated proteins also include Hsp70 and members of its family such as Hsp27 and gp96, thereby suggesting the role of Hsp90 co-chaperones in compensating for Hsp90 function after Hsp90 inhibition. Considering Hsp70’s role in antiapoptosis, it was postulated that a combination therapy involving a multitarget approach could be carried out. Consequently inhibition of both Hsp90 and Hsp70 in U87-MG glioma cells resulted in 60% cell death indicating the importance of combination therapy for glioma therapeutics

Database Queries that Explain their Work

Provenance for database queries or scientific workflows is often motivated as providing explanation, increasing understanding of the underlying data sources and processes used to compute the query, and reproducibility, the capability to recompute the results on different inputs, possibly specialized to a part of the output. Many provenance systems claim to provide such capabilities; however, most lack formal definitions or guarantees of these properties, while others provide formal guarantees only for relatively limited classes of changes. Building on recent work on provenance traces and slicing for functional programming languages, we introduce a detailed tracing model of provenance for multiset-valued Nested Relational Calculus, define trace slicing algorithms that extract subtraces needed to explain or recompute specific parts of the output, and define query slicing and differencing techniques that support explanation. We state and prove correctness properties for these techniques and present a proof-of-concept implementation in Haskell.Comment: PPDP 201

Effect of IN-OVO injection with Nano Iron -Particles on Physiological Responses and Performance of Broiler Chickens under Saini Conditions

A total of 600 fertile eggs, in a completely randomized design were used to investigate the effects of Iron nano-particles IN-OVO injection on productive performance, immune status and physiological responses in broiler chickens. The eggs were divided into 6 groups that assigned as: T1 (control; without injection), T2 (injected with 0.1 ml saline 9.0%; sham control), T3; (injected with 0.1 ml of 20 ppm Fe-NPs organic, T4 (injected with 0.1 ml of 20 ppm Fe-Nano inorganic), T5 (injected with 0.1 ml of 20 ppm Fe organic) and T6 (injected with 0.1 ml of 20 ppm Fe-inorganic). At 7th day of incubation, the corresponding doses were in- ovo injected in 0.1 ml solution into the air sac. The results showed that: Hatchability was highly significant (P< 0.01) in T1, 0.1 ml of 20 ppm Fe-NPs, 0.1 ml of 20-ppm Fe-NPs-Alimet chelate, 0.1 ml of 20 ppm Fe-Aliment chelate and 0.1 ml of 20-ppm Fe-Aliment chelate. The egg weight was higher (P< 0.01) in T2. There was an increase (P< 0.01) in chick weight in controls, other Fe-NPs organic or Fe-NPs- inorganic and Fe organic in comparison with other treatments. In addition, chick body weight to egg weight ratio in controls, Fe-Nano organic and FeNPs- inorganic was higher (P < 0.01) than in the other groups. T3 has shown the highest (P< 0.01) relative weight compared to the other treatments. Serum Fe content and liver function were (P< 0.01) higher in by using Fe-NPs, Fe-NPs alimet inorganic and Fe-organic than other treatments. The treatments of Fe-NPs- organic and Fe-Aliment chelate, chickens' blood hemoglobin increased significantly compared with the other treatments. These results suggest that Fe-NPs, Fe-NPs-Alimet chelate and Fe-Alimet chelate improved embryonic growth and development

Could the Anti-Chaperone VER155008 Replace Temozolomide for Glioma Treatment

Cancer inducible molecular chaperone HSP90 is of great importance as an anticancer target. Proteomic analysis showed that inhibiting HSP90 by the geldanamycin derivative, 17-AAG elevated the expression of the co-chaperone Hsp70. In this study we used HSP90 selective inhibitor 17-AAG and HSP70/90 dual inhibitor, VER155008 (VER) in U87-MG glioma cells. miRNAs microarray technology was used to evaluate the efficacy of these inhibitory drugs compared with temozolomide (TMZ), used as a standard treatment for glioma. Microarrays data identified 154 differentially expressed miRNAs using stringent or unstringent parameters. 16 miRNAs were overlapped between treatments, 13 upregulated and one downregulated miRNA were overlapped between TMZ and VER. The miRNA target prediction software was used for these overlapped miRNAs and identified 6 of the 13 upregulated miRNAs target methyltransferase genes. The IC50, together with Akt and HSP70 and 90 protein level data favour VER and TMZ to 17-AAG, however due to the selectivity of VER to cancer cells as a potent antichaperon, it may be more favourable to the standard TMZ

Evaluasi Kinerja Bus Patas Antar Kota Dalam Propinsi Po. Rukun Jaya ( Studi Kasus Trayek Surabaya - Blitar )

Tingginya minat masyarakat akan kebutuhan transportasi bus umum dengan jumlah armada yang tidak sesuai menjadi salah satu permasalahan yang mempengaruhi kinerja pelayanan dari armada bus patas PO. Rukun Jaya rute perjalanan Blitar – Pare - Surabaya. Oleh karena itu perlu dilakukan evaluasi untuk peningkatan kinerja. Kinerja armada bus patas rute Blitar – Pare - Surabaya berdasarkan Indikator Standar Direktorat Jenderal Perhubungan Darat diperoleh ; load factor rata-rata selama tujuh hari (Minggu s/d Sabtu) pada interval waktu survey pukul 06:00 – 08:00, 10:00 – 12:00, dan 14:00-16:00 rute Blitar – Pare – Surabaya sebesar 0.88, kecepatan perjalanan 34.59 km/jam, headway rata-rata 37.52 menit, rata-rata waktu perjalanan sebesar 1.74 menit/km, frekuensi sebesar 1.19 Kend/jam, sedangkan untuk rute Surabaya – Pare – Blitar dengan interval waktu survey masing-masing adalah pukul 08:00-10:00, 12:00-14:00, dan 16:00-18:00 selama tujuh hari untuk rata-rata load factor sebesar 1.13, kecepatan perjalanan 33.03 km/jam, headway rata-rata 38.1 menit, rata-rata waktu perjalanan 1.82 menit/km, frekuensi sebesar 1 Kend/jam. Hasil dari evaluasi kinerja armada bus patas PO. Rukun Jaya diperoleh kinerja pelayanan armada dengan total nilai bobot untuk rute Blitar – Pare – Surabaya sebesar 21 dan rute Surabaya – Pare – Blitar sebesar 19 yang secara keseluruhan masuk pada kriteria baik yaitu dengan nilai antara 18 – 24

Sensory organ like response determines the magnetism of zigzag-edged honeycomb nanoribbons

We present an analytical theory for the magnetic phase diagram for zigzag edge terminated honeycomb nanoribbons described by a Hubbard model with an interaction parameter U . We show that the edge magnetic moment varies as ln U and uncover its dependence on the width W of the ribbon. The physics of this owes its origin to the sensory organ like response of the nanoribbons, demonstrating that considerations beyond the usual Stoner-Landau theory are necessary to understand the magnetism of these systems. A first order magnetic transition from an anti-parallel orientation of the moments on opposite edges to a parallel orientation occurs upon doping with holes or electrons. The critical doping for this transition is shown to depend inversely on the width of the ribbon. Using variational Monte-Carlo calculations, we show that magnetism is robust to fluctuations. Additionally, we show that the magnetic phase diagram is generic to zigzag edge terminated nanostructures such as nanodots. Furthermore, we perform first principles modeling to show how such magnetic transitions can be realized in substituted graphene nanoribbons.Comment: 5 pages, 5 figure