Cellular Signaling Pathways in Alcoholic Liver Disease

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Age at menarche and the menstrual pattern of secondary school adolescents in central India

Background: Population studies on characteristics of menstrual cycles are scarce. Knowledge on this variability is necessary for patient education and to guide clinical evaluation.Methods: A cross sectional study was conducted and 622 school girls were selected randomly. A pretested questionnaire was used to gather data.Results: Mean age of participants was 16.9 ± 1 years. About 92.2% had attained menarche. Probit analysis of the status-quo data yielded median age at menarche of 14.8 (13.9-15.3) years and by recall method to be 15.8 ± 1 years. The mean age at menarche was, significantly, 0.3 years younger for urban females compared with rural ones. Cycle length between 21-35 days was observed in 70.3% of the girls. Mean duration of flow was 4 ± 1.3 days. Menstrual cycles were irregular in 42.8% of the subjects. Overall prevalence of dysmenorrhoea was 72%. and of PMS was 75.4%.Conclusions: Age of menarche was found to be significantly delayed. Considerable number of students complained of dysmenorrhoea and premenstrual symptoms

Tandem ring‐opening–ring‐closing metathesis for functional metathesis catalysts

Use of a tandem ring-opening–ring-closing metathesis (RORCM) strategy for the synthesis of functional metathesis catalysts is reported. Ring opening of 7-substituted norbornenes and subsequent ring-closing metathesis forming a thermodynamically stable 6-membered ring lead to a very efficient synthesis of new catalysts from commercially available Grubbs’ catalysts. Hydroxy functionalized Grubbs’ first- as well as third-generation catalysts have been synthesized. Mechanistic studies have been performed to elucidate the order of attack of the olefinic bonds. This strategy was also used to synthesize the ruthenium methylidene complex

Design and Implementation Of Vehicle Tracking System Using GPS

Surveillance system using phone line for security and tracking. Based on the above statement, it is targeted that this project will serve as good indication of how important it is to curb car theft in the country. Surveillance is specified to car alarm system and the means of sending the data to the owner of the vehicle using SMS when the alarm is triggered. Due to the inefficient conventional car security system, the possibility of the car can be stolen is high. The main reason is that the alarm is limited to the audible distance. Somehow if there is another way of transmitting the alarm to the car owner ,tracking the vehicle ,knowing the exactly that the car is been stolen at the same time that is not limited to the audible and line of sight, the system can be upgraded. SMS is a good choice of the communication to replace the conventional alarm, because it can be done and does not require much cost. Although most of people know  GPS can provide more security for the car but the main reason people does not apply it because the cost. Advance car security system is too expensive. Cost for the gadget is too high. Beside that, people also must pay for the service monthly. Tracking systems were first developed for the shipping industry because they wanted to determine where each vehicle was at any given time. Passive systems were developed in the beginning to fulfill these requirements. For the applications which require real time location information of the vehicle, these systems can't be employed because they save the location information in the internal storage and location information can only be accessed when vehicle is available. To achieve automatic Vehicle Location system that can transmit the location information in real time. Active systems are developed. Real time vehicular tracking system incorporates a hardware device installed in the vehicle (In-Vehicle Unit) and a remote Tracking server. The information is transmitted to Tracking server using GSM/GPRS modem on GSM network by using SMS or using direct TCP/IP connection with Tracking server through GPRS. Tracking server also has GSM/GPRS modem that receives vehicle location information via GSM network and stores this information in database. This information is available to authorized users of the system via website over the internet. Keywords: GPS,GPRS,Sensor

FICO score - ROLE IN MODERN FINANCIAL SYSTEM

FICO assessment business is a corner portion in the budgetary administrations field. In the post-changes period, with expanded action in the Indian Financial division both existing and new organizations are selecting money from the capital business sector. The opposition among firms for a cut of the reserve funds cake has expanded. FICO score business in India is a sweet spot as it is on the cusp of vigorous development potential, driven by three triggers: Strong capex cycle in Indian economy, lower infiltration of corporate security market and administrative push because of execution of Basel II standards. FICO score helps in the improvement of money related markets. FICO score is a financial specialist administration and a rating organization is required to keep up the most astounding conceivable level of expository capability and trustworthiness. The diagnostic structure of rating manages assessment of both the business and monetary dangers connected with that element. Other than subjective perspectives like administration abilities additionally assume an extensive part in deciding a rating. FICO assessments set up a connection between danger and return. They in this manner give a measuring stick against which to quantify the danger characteristic in any instrument. Explanatory structure of rating manages assessment of both the business and money related dangers connected with that substance. The Reserve Bank of India liaises with SEBI, on the issue of rating offices' adherence to IOSCO Code of Conduct Fundamentals.Given the droop confronted by economies all around and the ascent in the quantity of defaultees, the time has come for the channel had a solid FICO score framework set up to guarantee smooth operation for the whole chain. The most noteworthy change in late identifies with accentuation on their responsibility and more imperative, the alert in controllers' utilization of evaluations

Thanatochemistry: Study of synovial fluid potassium

Death interval estimation is one of the major attributes obtained from thanatochemistry. Body fluids like vitreous humour have been consistently used to estimate death interval from regression equations, but these may be useless when dealing with eye trauma, ocular disorders or in mutilated remains. Until recently, there was no consistent assessment of the reliability of measurements of the synovial fluid for death interval estimation. The purpose of this paper is to test previously developed regression formulae for estimating death interval based on synovial fluid potassium and to assess its reliability in estimating death interval. Synovial fluid potassium was measured on a sample of 308 individuals. Death interval was regressed on synovial fluid potassium and a regression formula was obtained. The regression model provided a 95% confidence interval of ±3.0 h and a correlation coefficient of 0.739. Compared to other studies, regression formulae based on the synovial fluid potassium in the present study provided considerably less standard errors.KEYWORDS Thanatochemistry; Cadaveric; Synovial fluid; Potassium; Postmortem interva

Association between various antioxidants in normals and chronic obstructive pulmonary disease, their alteration and impact of smoking and disease on levels of antioxidants

Background: There is total alteration of various antioxidants in response to the oxidative stress, which is one of the major patho-physiologic hallmarks in chronic obstructive pulmonary disease (COPD) development. This study aims to establish the correlation between different antioxidants in normals and COPD, study the alteration in the correlation due to COPD and smoking as well as the impact of COPD and smoking on antioxidants levels.Methods: Study comprises of 96 normals as group I and 96 COPD patients as group II. The antioxidants albumin (Alb), bilirubin (Bil), uric acid (UA) ceruloplasmin (Cp), glutathione peroxidase (GSHPx), catalase (CAT) and superoxide dismutase 3 (SOD3) were estimated.Results: Significant lower serum Alb, UA, SOD3 and increased serum Cp and GSHPx were found in Group II. Significant correlation was found between Alb and UA (r=0.24); Bil and UA (r=0.26); Alb and CAT (r=0.211) and SOD3 and CAT (r=0.318) in normals. However, these correlations were altered in COPD where Alb correlates with Bil (r=0.235); UA with CAT (r=0.203) and SOD3 with GSHPx (r=-0.27). The correlation between SOD3 and CAT remained unaltered. Similar correlation of UA with Alb and Bil was observed in nonsmoker normals and between SOD3 and CAT in smoker normals. In COPD, no correlation was seen in nonsmokers, while in smokers Alb correlates with Bil (r=0.316) and SOD3 with CAT (r=0.317).Conclusions: These alterations may have clinical ramifications in further understanding the pathogenesis of COPD and developing therapeutic approaches

Synthesis of Li 2 Ni 2 (MoO 4) 3 as a high-performance positive electrode for asymmetric supercapacitors

A NASICON-type compound, Li2Ni2(MoO4)3 was successfully synthesized via a combustion method. The as-synthesized Li2Ni2(MoO4)3 is fiber-like grains with an average length of 1–2 μm. As an electrode for pseudocapacitors, in 2 M LiOH, its specific capacitance reached 1137 F g−1 and 717 F g−1 at current density of 1 A g−1 and 20 A g−1 respectively, exhibiting 63% capacity retention. Moreover, in asymmetric supercapacitors with an activated carbon electrode as the negative electrode, the energy density of 36.5 W h kg−1 was obtained at the average power density of 420 W kg−1. The fabricated asymmetric supercapacitor also exhibited good electrochemical stability, specifically, the specific capacitance was retained at 68% of the initial value even after 10 000 cycles at 2 A g−1. These observations suggest that the prepared Li2Ni2(MoO4)3 is a prospective candidate for high-performance supercapacitors