Electronic structure and magnetic properties of Gd-doped and Eu-rich EuO

The effects of Gd doping and O vacancies on the magnetic interaction and Curie temperature of EuO are studied using first-principles calculations. Linear response calculations in the virtual crystal approximation show a broad maximum in the Curie temperature as a function of doping, which results from the combination of the saturating contribution from indirect exchange and a decreasing contribution from the f-d hopping mechanism. Non-Heisenberg interaction at low doping levels and its effect on the Curie temperature are examined. The electronic structure of a substitutional Gd and of an O vacancy in EuO are evaluated. When the 4f spins are disordered, the impurity state goes from single to double occupation, but correlated bound magnetic polarons are not ruled out. At higher vacancy concentrations typical for Eu-rich EuO films, the impurity states broaden into bands and remain partially filled. To go beyond the homogeneous doping picture, magnetostructural cluster expansions are constructed, which describe the modified exchange parameters near Gd dopants or O vacancies. Thermodynamic properties are studied using Monte Carlo simulations. The Curie temperature for Gd-doped EuO agrees with the results of the virtual crystal approximation and shows a maximum of about 150 K. At 3.125% vacancy concentration the Curie temperature increases to 120 K, consistent with experimental data for Eu-rich film samples.Comment: 15 pages, 13 figures, under review in Physical Review

SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons.

The mechanism for the earliest response of central neurons to hypoxia-an increase in voltage-gated sodium current (INa)-has been unknown. Here, we show that hypoxia activates the Small Ubiquitin-like Modifier (SUMO) pathway in rat cerebellar granule neurons (CGN) and that SUMOylation of NaV1.2 channels increases INa. The time-course for SUMOylation of single NaV1.2 channels at the cell surface and changes in INa coincide, and both are prevented by mutation of NaV1.2-Lys38 or application of a deSUMOylating enzyme. Within 40 s, hypoxia-induced linkage of SUMO1 to the channels is complete, shifting the voltage-dependence of channel activation so that depolarizing steps evoke larger sodium currents. Given the recognized role of INa in hypoxic brain damage, the SUMO pathway and NaV1.2 are identified as potential targets for neuroprotective interventions

K2P channels and their protein partners.

A decade since their discovery, the K2P channels are recognized as pathways dedicated to regulated background leakage of potassium ions that serve to control neuronal excitability. The recent identification of protein partners that directly interact with K2P channels (SUMO, 14-3-3 and Vpu1) has exposed new regulatory pathways. Reversible linkage to SUMO silences K2P1 plasma membrane channels; phosphorylation of K2P3 enables 14-3-3 binding to affect forward trafficking, whereas it decreases open probability of K2P2; and, Vpu1, an HIV encoded partner, mediates assembly-dependent degradation of K2P3. An operational strategy has emerged: tonic inhibition of K2P channels allows baseline neuronal activity until enhanced potassium leak is required to suppress excitability

Effects of medium-induced ρ−ω\rho-\omega meson mixing on the equation of state in isospin-asymmetric nuclear matter

We reexamine effects of the $\rho-\omega$ meson mixing mediated by nucleon polarizations on the symmetry energy in isospin-asymmetric nuclear matter. Taking into account the rearrangement term neglected in previous studies by others, we evaluate the $\rho-\omega$ mixing angle in a novel way within the Relativistic Mean-Field Models with and without chiral limits. It is found that the symmetry energy is significantly softened at high densities contrary to the finding in earlier studies. As the first step of going beyond the lowest-order calculations, we also solve the RPA equation for the $\rho-\omega$ mixing. In this case, it is found that the symmetry energy is not only significantly softened by the $\rho-\omega$ mixing at supra-saturation densities, similar to the lowest-order $\rho-\omega$ mixing, but interestingly also softened at subsaturation densities. In addition, the softening of the symmetry energy at subsaturation densities can be partly suppressed by the nonlinear self-interaction of the $\sigma$ meson.Comment: Significant changes made. Accepted version to appear in PRC (2009

GRB 060218/SN 2006aj: A Gamma-Ray Burst and Prompt Supernova at z=0.0335

We report the imaging and spectroscopic localization of GRB 060218 to a low-metallicity dwarf starburst galaxy at z = 0.03345 +/- 0.00006. In addition to making it the second nearest gamma-ray burst known, optical spectroscopy reveals the earliest detection of weak, supernova-like Si II near 5720 Angstroms (0.1c), starting 1.95 days after the burst trigger. UBVRI photometry obtained between 1 and 26 days post-burst confirms the early rise of supernova light, and suggests a short time delay between the gamma-ray burst and the onset of SN 2006aj if the early appearance of a soft component in the X-ray spectrum is understood as a ``shock breakout''. Together, these results verify the long-hypothesized origin of soft gamma-ray bursts in the deaths of massive stars.Comment: 5 pages, 2 figure