Effect of soybean plant phenols and flavonoid on the mean leaf area consumed by Spodopteralitura and Spilosoma obliqua larvae

The aim of the present investigation was to study the effect of soybean plant phenols and flavonoid content on the mean leaf area consumed by Spodopteralitura and Spilosoma obliqua larva. Phenols and flavonoid content in methanolic leaf extract of thirty three genotypes of soybean were determined by spectrophotometrically. Thehighest and lowest phenolic content were found in genotypes JS-20-41(2.2±0.073 mg/g) and CSB 904 (0.45 ±0.11 mg/g), respectively. While the highest and lowest flavonoid content was found in genotypes SL 979 4.686± 0.062 mg QE/ g, respectively. In correlation study a highly significant negative correlation was observed between mean leaf area consumed (cm2) by S. litura, phenol content (-0.741 ) and flavonoid content (-0.737) similarly a highly significant negative correlation was observed between mean leaf area consumed by S. obliqua, phenol content (-0.728) and flavonoid content (-0.736) in leaves. Hence it can be concluded that, the genotypes which were having higher phenol and flavonoid content in their leaves offered resistance against S. litura and S. boliqua in soybean

'Decision support system (DSS) for prevention of cardiovascular disease (CVD) among hypertensive (HTN) patients in Andhra Pradesh, India'--a cluster randomised community intervention trial.

RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are.BACKGROUND: Very few studies having decision support systems as an intervention report on patient outcomes for cardiovascular disease in the Western world. The potential role of decision support system for the management of blood pressure among Indian hypertensives remains unclear. We propose a cluster randomised trial that aims to test the effectiveness and cost effectiveness of DSS among Indian hypertensive patients. METHODS: The trial design is a cluster randomised community intervention trial, in which the participants would be adult male and female hypertensive patients, in the age group of 35 to 64 years, reporting to the Primary Health Care centres of Mahabubnagar district, Andhra Pradesh, India. The objective of the study is to test the effectiveness and compare the cost effectiveness and cost utility among hypertensive subjects randomized to receive either decision support system or a chart based algorithmic support system in urban and rural areas of a district in the state of Andhra Pradesh, India (baseline versus 12 months follow up). The primary outcome would be a comparison of the systolic blood pressure at 0 and 12 months among hypertensive patients randomized to receive the decision support system or the chart based algorithmic support system. Computer generated randomisation and an investigator and analyser blinded method would be followed. 1600 participants; 800 to each arm; each arm having eight clusters of hundred participants each have been recruited between 01 August 2011 - 01 March 2012. A twelve month follow up will be completed by March 2013 and results are expected by April 2013. DISCUSSION: This cluster randomized community intervention trial on DSS will enable policy makers to find out the effectiveness, cost effectiveness and cost utility of decision support system for management of blood pressure among hypertensive patients in India. Most of the previous studies on decision support system have focused on physician performance, adherence and on preventive care reminders. The uniqueness of the proposed study lies in finding out the effectiveness of a decision support system on patient related outcomes. TRIAL REGISTRATION: CTRI/2012/03/002476, Clinical Trial Registry - India

Development and validation of a clinical and computerised Decision Support System for Management of Hypertension (DSS-HTN) at a Primary Health Care (PHC) setting

Background: Hypertension remains the top global cause of disease burden. Decision support systems (DSS) could provide an adequate and cost-effective m

Evaluation of hysterectomy in a tertiary care hospital of central India: a retroprospective study

Background: Hysterectomy is the most common gynaecological surgical procedure after caesarean section. In India there is lower rate (4-6%) of hysterectomy has been reported, while there is higher frequency of hysterectomy (10-20%) in developed countries. Currently there are three main types of hysterectomy operations in practice for benign diseases abdominal hysterectomy, vaginal hysterectomy and laparoscopic hysterectomy. Abdominal hysterectomy remains the predominant method of uterus removal. The present study was planned t to analyse changes in the trends of hysterectomy from past 3 year in the study area.Methods: The present observational study was conducted in department of obstetrics and gynaecology and associated Dr. B.R.A.M. hospital Raipur (CG), India. Data was collected retrospectively from January 2009 to May 2012 from hospital medical records. Prospectively data was obtained from patient and his file from June 2013 to September 2014. Data was compiled in MS-excel and checked for its completeness and correctness, and then it was analyzed by using suitable software.Results: Total no of hysterectomy conducted in study duration was 1000. Study showed declining trend of hysterectomy in our institute. Most common age group of hysterectomy was 41-50 year. which 45.8% followed by age group 31-40 that is 32.5%. Most common indication of hysterectomy was fibroid uterus 33.6% followed by prolapse uterus 29.5%. 29% cases were operated via vaginal route for descent of uterus and 21% cases operated by vaginal route for non-descent uterus.50% cases were operated via abdominal route. Average operating time for TAH was 1.43±0.50, for VH was 1.08±0.03. Average hospital stay for TAH was 8.87±3.31 and VH was 5.27±1.07. Conclusions: In our study it had been seen that rate of hysterectomy is in decreasing trend as more conservative approach is now preferred. To minimize most of complications of hysterectomy second opinion fresh eyes and multi-disciplinary approach is recommend in all patients undergoing this procedure

Physicochemical equivalence of generic antihypertensive medicines (EQUIMEDS): protocol for a quality of medicines assessment.

BACKGROUND: Prevention and optimal management of hypertension in the general population is paramount to the achievement of the World Heart Federation (WHF) goal of reducing premature cardiovascular disease (CVD) mortality by 25% by the year 2025 and widespread access to good quality antihypertensive medicines is a critical component for achieving the goal. Despite research and evidence relating to other medicines such as antimalarials and antibiotics, there is very little known about the quality of generic antihypertensive medicines in low-income and middle-income countries. The aim of this study was to determine the physicochemical equivalence (percentage of active pharmaceutical ingredient, API) of generic antihypertensive medicines available in the retail market of a developing country. METHODS: An observational design will be adopted, which includes literature search, landscape assessment, collection and analysis of medicine samples. To determine physicochemical equivalence, a multistage sampling process will be used, including (1) identification of the 2 most commonly prescribed classes of antihypertensive medicines prescribed in Nigeria; (2) identification of a random sample of 10 generics from within each of the 2 most commonly prescribed classes; (3) a geographical representative sampling process to identify a random sample of 24 retail outlets in Nigeria; (4) representative sample purchasing, processing to assess the quality of medicines, storage and transport; and (5) assessment of the physical and chemical equivalence of the collected samples compared to the API in the relevant class. In total, 20 samples from each of 24 pharmacies will be tested (total of 480 samples). DISCUSSION: Availability of and access to quality antihypertensive medicines globally is therefore a vital strategy needed to achieve the WHF 25×25 targets. However, there is currently a scarcity of knowledge about the quality of antihypertensive medicines available in developing countries. Such information is important for enforcing and for ensuring the quality of antihypertensive medicines

Cost effective interventions for the prevention of cardiovascular disease in low and middle income countries: a systematic review.

BACKGROUND: While there is good evidence to show that behavioural and lifestyle interventions can reduce cardiovascular disease risk factors in affluent settings, less evidence exists in lower income settings.This study systematically assesses the evidence on cost-effectiveness for preventive cardiovascular interventions in low and middle-income settings. DESIGN: Systematic review of economic evaluations on interventions for prevention of cardiovascular disease. DATA SOURCES: PubMed, Web of Knowledge, Scopus and Embase, Opensigle, the Cochrane database, Business Source Complete, the NHS Economic Evaluations Database, reference lists and email contact with experts. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: we included economic evaluations conducted in adults, reporting the effect of interventions to prevent cardiovascular disease in low and middle income countries as defined by the World Bank. The primary outcome was a change in cardiovascular disease occurrence including coronary heart disease, heart failure and stroke. DATA EXTRACTION: After selection of the studies, data were extracted by two independent investigators using a previously constructed tool and quality was evaluated using Drummond's quality assessment score. RESULTS: From 9731 search results we found 16 studies, which presented economic outcomes for interventions to prevent cardiovascular disease in low and middle income settings, with most of these reporting positive cost effectiveness results.When the same interventions were evaluated across settings, within and between papers, the likelihood of an intervention being judged cost effective was generally lower in regions with lowest gross national income. While population based interventions were in most cases more cost effective, cost effectiveness estimates for individual pharmacological interventions were overall based upon a stronger evidence base. CONCLUSIONS: While more studies of cardiovascular preventive interventions are needed in low and mid income settings, the available high-level of evidence supports a wide range of interventions for the prevention of cardiovascular disease as being cost effective across all world regions.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

Electronic Health Record System using Blockchain Technology

The healthcare sector is frequently known for being delicate and intricate.Individuals' sensitive information must be kept safe, secure, and protected.Blocks of the blockchain are secured and bound to each other using cryptographic principles. By maintaining the patient at the centre of the medical ecosystem system and establishing greater security, interoperability, and privacy of stored patient records, blockchain has the potential to eradicate the problems ailing the industry and transform healthcare. By decentralizing and encrypting health records, blockchain ensures that patient data is securely stored and tamper-proof. Additionally, blockchain can facilitate the seamless exchange of medical information between different healthcare providers, leading to better coordination of care and reduced medical errors. By leveraging Ethereum's smart contract functionality, healthcare organizations can securely store and share patient data, ensuring its integrity and confidentiality. Moreover, Ethereum's programmable nature allows for the development of decentralized applications (DApps) that can streamline various healthcare processes, such as medical record management, supply chain tracking, and clinical trials. Overall, the integration of blockchain in the healthcare industry has the potential to revolutionize the way healthcare data is managed, ensuring privacy, security, and efficiency in patient care