Anomalous quantum chaotic behavior in nanoelectromechanical structures

It is predicted that for sufficiently strong electron-phonon coupling an anomalous quantum chaotic behavior develops in certain types of suspended electro-mechanical nanostructures, here comprised by a thin cylindrical quantum dot (billiard) on a suspended rectangular dielectric plate. The deformation potential and piezoelectric interactions are considered. As a result of the electron-phonon coupling between the two systems the spectral statistics of the electro-mechanic eigenenergies exhibit an anomalous behavior. If the center of the quantum dot is located at one of the symmetry axes of the rectangular plate, the energy level distributions correspond to the Gaussian Orthogonal Ensemble (GOE), otherwise they belong to the Gaussian Unitary Ensemble (GUE), even though the system is time-reversal invariant.Comment: 4 pages, pdf forma

Rigorous analysis of Casimir and van der Waals forces on a silicon nano-optomechanical device actuated by optical forces

We show how van der Waals and Casimir forces affect nano-optomechanical devices, by changing their operation and design limits.</p

Contact and intrinsic coagulation pathways are activated and associated with adverse clinical outcomes in COVID-19

Abstract Coagulation activation is a prominent feature of severe acute respiratory syndrome coronavirus 2 (COVID-19) infection. Activation of the contact system and intrinsic pathway has increasingly been implicated in the prothrombotic state observed in both sterile and infectious inflammatory conditions. We therefore sought to assess activation of the contact system and intrinsic pathway in individuals with COVID-19 infection. Baseline plasma levels of protease:serpin complexes indicative of activation of the contact and intrinsic pathways were measured in samples from inpatients with COVID-19 and healthy individuals. Cleaved kininogen, a surrogate for bradykinin release, was measured by enzyme-linked immunosorbent assay, and extrinsic pathway activation was assessed by microvesicle tissue factor–mediated factor Xa (FXa; MVTF) generation. Samples were collected within 24 hours of COVID-19 diagnosis. Thirty patients with COVID-19 and 30 age- and sex-matched controls were enrolled. Contact system and intrinsic pathway activation in COVID-19 was demonstrated by increased plasma levels of FXIIa:C1 esterase inhibitor (C1), kallikrein:C1, FXIa:C1, FXIa:α1-antitrypsin, and FIXa:antithrombin (AT). MVTF levels were also increased in patients with COVID-19. Because FIXa:AT levels were associated with both contact/intrinsic pathway complexes and MVTF, activation of FIX likely occurs through both contact/intrinsic and extrinsic pathways. Among the protease:serpin complexes measured, FIXa:AT complexes were uniquely associated with clinical indices of disease severity, specifically total length of hospitalization, length of intensive care unit stay, and extent of lung computed tomography changes. We conclude that the contact/intrinsic pathway may contribute to the pathogenesis of the prothrombotic state in COVID-19. Larger prospective studies are required to confirm whether FIXa:AT complexes are a clinically useful biomarker of adverse clinical outcomes.</jats:p