Wearing colored glasses can influence the exercise performance and testosterone concentration

Perception of red color is associated with higher testosterone concentration and better human performance. Thus, we evaluated the acute effects of wearing colored-lens glasses on the YoYo intermittent endurance exercise test 2 (YoYoIE2) performance indicators and testosterone concentration. Ten soccer players performed three YoYoIE2 (counterbalanced crossover) wearing colorless (control), blue- or red-lensed glasses (2–4 days of rest in between). YoYoIE2 performance did not differ among the trials (p>0.05), but blood testosterone increased post-exercise in red compared to red baseline (red=14%, effect size=0.75). Analysis showed faster heart rate recovery (p0.05) among the trials. Wearing red-colored lenses during high-intensity intermittent exercise increased testosterone concentration, but do not influence performance

Accuracy of microRNAs as markers for the detection of neck lymph node metastases in patients with head and neck squamous cell carcinoma

Background: the presence of metastatic disease in cervical lymph nodes of head and neck squamous cell carcinoma (HNSCC) patients is a very important determinant in therapy choice and prognosis, with great impact in overall survival. Frequently, routine lymph node staging cannot detect occult metastases and the post-surgical histologic evaluation of resected lymph nodes is not sensitive in detecting small metastatic deposits. Molecular markers based on tissue-specific microRNA expression are alternative accurate diagnostic markers. Herein, we evaluated the feasibility of using the expression of microRNAs to detect metastatic cells in formalin-fixed paraffin-embedded (FFPE) lymph nodes and in fine-needle aspiration (FNA) biopsies of HNSCC patients.Methods: An initial screening compared the expression of 667 microRNAs in a discovery set comprised by metastatic and non-metastatic lymph nodes from HNSCC patients. the most differentially expressed microRNAs were validated by qRT-PCR in two independent cohorts: i) 48 FFPE lymph node samples, and ii) 113 FNA lymph node biopsies. the accuracy of the markers in identifying metastatic samples was assessed through the analysis of sensitivity, specificity, accuracy, negative predictive value, positive predictive value, and area under the curve values.Results: Seven microRNAs highly expressed in metastatic lymph nodes from the discovery set were validated in FFPE lymph node samples. MiR-203 and miR-205 identified all metastatic samples, regardless of the size of the metastatic deposit. Additionally, these markers also showed high accuracy when FNA samples were examined.Conclusions: the high accuracy of miR-203 and miR-205 warrant these microRNAs as diagnostic markers of neck metastases in HNSCC. These can be evaluated in entire lymph nodes and in FNA biopsies collected at different time-points such as pre-treatment samples, intraoperative sentinel node biopsy, and during patient follow-up. These markers can be useful in a clinical setting in the management of HNSCC patients from initial disease staging and therapy planning to patient surveillance.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal de São Paulo, Dept Biol Sci, Lab Canc Mol Biol, BR-04039032 São Paulo, SP, BrazilBarretos Canc Hosp, Mol Oncol Res Ctr, BR-14784400 Barretos, SP, BrazilBarretos Canc Hosp, Dept Pathol, BR-14784400 Barretos, SP, BrazilBarretos Canc Hosp, Dept Head & Neck Surg, BR-14784400 Barretos, SP, BrazilDuke NUS Grad Med Sch, Canc Stem Cell Biol Program, Singapore 169857, SingaporeUniversidade Federal de São Paulo, Dept Biol Sci, Lab Canc Mol Biol, BR-04039032 São Paulo, SP, BrazilFAPESP: 2012/14837-7Web of Scienc

Transmission fiber chromatic dispersion dependence on temperature: implications on 40 Gb/s performance

In this letter we will evaluate the performance degradation of a 40 km high-speed (40 Gb/s) optical System, induced by optical fiber variations of the chromatic dispersion induced by temperature changes. The chromatic dispersion temperature sensitivity will be estimated based on the signal quality parameters

Apoplexia em tumor hipofisário

Pituitary tumor apoplexy is a medical emergency due to acute infarction or hemorrhage in the pituitary gland. In this review, the authors discuss the sellar anatomy, the pituitary gland and adenomas' vascularization and the general aspects of the syndrome such as its ethiopatogenesis, predisposing factors, clinical features, treatment and prognosis.A apoplexia em tumor hipofisário é uma emergência médica decorrente do infarto agudo ou hemorrágico na glândula hipófise. Nesta revisão os autores discutem a anatomia da região selar, a vascularização da hipófise e adenomas hipofisários, e demais aspectos da síndrome como etiopatogenia, fatores predisponentes, quadro clínico, tratamento e prognóstico

Analysis of the effect of renal excretory system cooling during thermal radiofrequency ablation in an animal model

Objective: Analysis of renal excretory system integrity and efficacy of radiofrequency ablation with and without irrigation with saline at 2 o C (SF2). Materials and Methods: The median third of sixteen kidneys were submitted to radiofrequency (exposition of 1 cm) controlled by intra-surgical ultrasound, with eight minutes cycles and median temperature of 90 o C in eight female pigs. One excretory renal system was cooled with SF2, at a 30ml/min rate, and the other kidney was not. After 14 days of post-operatory, the biggest diameters of the lesions and the radiological aspects of the excretory system were compared by bilateral ascending pyelogram and the animals were sacrificed in order to perform histological analysis. Results: There were no significant differences between the diameters of the kidney lesions whether or not exposed to cooling of the excretory system. Median diameter of the cooled kidneys and not cooled kidneys were respectively (in mm): anteroposterior: 11.46 vs. 12.5 (p = 0.23); longitudinal: 17.94 vs. 18.84 (p = 0.62); depth: 11.38 vs. 12.25 (p = 0.47). There was no lesion of the excretory system or signs of leakage of contrast media or hydronephrosis at ascending pyelogram. Conclusion: Cooling of excretory system during radiofrequency ablation does not significantly alter generated coagulation necrosis or affect the integrity of the excretory system in the studied model.Pontifical Catholic University of Campinas Faculty of MedicineRadium InstituteFederal University of São PauloUniversity of Campinas School of Medical SciencesUNIFESPSciEL

A Social Logic of Energy: A data science approach to understanding and modelling energy transitions of India’s urban poor

Continued use of traditional solid biomass fuels for cooking in Indian households poses a serious public health risk. Particulate emissions in the form of soot contributed to approximately 600,000 deaths in 2019, a burden that falls disproportionately on women, children, and vulnerable populations. Despite over 95% of the population having access to clean cooking fuel distribution, following recent government initiatives to promote liquefied petroleum gas, biomass cooking fuel use is still widespread. This is the case even in cities, where low-income households have low levels of sustained clean cooking fuel use. Interventions to promote transition to clean cooking often focus on cost and technology, informed by an economic-technical view of energy transition, but not all households benefit as expected from these interventions. Previous studies on socio-economic determinants of transition offer limited insight into the reasons for why some households can slip through the net of such interventions. The explanation lies in the socio-cultural and economic heterogeneity across households and the inherent spatial inequalities in urban India. This thesis explores the influence of local socio-economic and cultural factors, and household practices and habits, on clean cooking transition with a view to understanding how the associated heterogeneity can be characterised, and integrated into quantitative energy models and methods. Public national survey and census data is supplemented with primary data collection, which provides valuable quantitative and qualitative data on low-income urban households. Tree-based regression is used to investigate the influence of socio-economic and cultural factors within quantitative models. Determinants are found to exhibit non-linear trends, with thresholds for change in influence on transition. A statistical clustering reveals different typologies of household amongst clean cooking adopters, indicative of different enabling circumstances and pathways to transition. Continued use of biomass is found to be common across recently transitioned households. The heterogeneity amongst low-income households, and the emergent transition pathways, are further investigated through data collected on low-income households in Bangalore. A novel method is used which combines mixed data in a two-stage clustering analysis, offering a means to characterise heterogeneity across households, identifying distinct transition pathways and associated barriers. The findings illustrate how wider socio-economic inequality is intertwined with access to sustained clean cooking. A Bayesian multilevel microsimulation approach is proposed to model the spatial heterogeneity in clean cooking at a city scale. This approach combines publicly available data to generate a synthetic population, and estimates cooking fuel use and fuel stacking using a Bayesian multilevel model. The model takes into account household cooking practices, local spatial effects, and city level economic and policy context. The model reveals how low uptake of clean cooking fuel, and continued biomass use, is related to underlying spatial socio-economic inequalities in cities.Fitzwilliam College, Worshipful Company of Leatherseller

Choros N. 10 by Heitor Villa-Lobos: Analyzing the Themes and Compositional Techniques of Brazilian Modernism

Heitor Villa-Lobos (b. March 5, 1887 - d. November 17, 1959) can be considered the most important composer in Brazilian music history. Although the composer is listed as one of the most influential composers in the history of the guitar, he reached his peak in his works for piano and symphonic groups. Works such as A Prole do Bebê (1 and 2), and the series of Chôros, came out during an extremely convoluted time, where Brazilian artists engaged in seeking an artistic representation of a unique Brazilian identity. Those works not only satisfied the hunger, but pushed the movement to a new level, which, some would argue, has never been surpassed by any other composer. Unlike his work for the guitar, on which hundreds of analyses and articles can easily be found, Chôros No 10 has had little to no attention from a theoretical viewpoint. Being considered perhaps Villa-Lobos’ masterpiece, this piece brought what is most Brazilian into classical music, with a calculated European influence among genuine Brazilian characteristics made into music. To date, there have been many writings about Chôros No 10 from a historical perspective. The theoretical writings about this piece are few, and in my research I was not able to find any such writings that were exhaustive or very in depth. This thesis analyzes the elements in Chôros No 10, such as themes and harmonic implications, linked to the historical background of the Brazilian Modernism in music

Vertical Field Effect Transistor based on Graphene-WS2 Heterostructures for flexible and transparent electronics

The celebrated electronic properties of graphene have opened way for materials just one-atom-thick to be used in the post-silicon electronic era. An important milestone was the creation of heterostructures based on graphene and other two-dimensional (2D) crystals, which can be assembled in 3D stacks with atomic layer precision. These layered structures have already led to a range of fascinating physical phenomena, and also have been used in demonstrating a prototype field effect tunnelling transistor - a candidate for post-CMOS technology. The range of possible materials which could be incorporated into such stacks is very large. Indeed, there are many other materials where layers are linked by weak van der Waals forces, which can be exfoliated and combined together to create novel highly-tailored heterostructures. Here we describe a new generation of field effect vertical tunnelling transistors where 2D tungsten disulphide serves as an atomically thin barrier between two layers of either mechanically exfoliated or CVD-grown graphene. Our devices have unprecedented current modulation exceeding one million at room temperature and can also operate on transparent and flexible substrates

Robust orienting to protofacial stimuli in autism

Newborn infants exhibit a remarkable tendency to orient to faces. This behavior is thought to be mediated by a subcortical mechanism tuned to the protoface stimulus: a face-like configuration comprising three dark areas on a lighter background. When this unique stimulus translates across their visual field, neurotypical infants will change their gaze or head direction to track the protoface [1–3] . Orienting to this low spatial frequency pattern is thought to encourage infants to attend to faces, despite their poor visual acuity [2,3] . By biasing the input into the newborn’s visual system, this primitive instinct may serve to ‘canalize’ the development of more sophisticated face representation. Leading accounts attribute deficits of face perception associated with Autism Spectrum Disorders (ASD) [4] to abnormalities within this orienting mechanism. If infants who are later diagnosed with ASD exhibit reduced protoface orienting, this may compromise the emergence of perceptual expertise for faces [5] . Here we report a novel effect that confirms that the protoface stimulus captures adults’ attention via an involuntary, exogenous process (Experiment 1). Contrary to leading developmental accounts of face perception deficits in ASD, we go on to show that this orienting response is intact in autistic individuals (Experiment 2)