3,377 research outputs found

    Assessing the "Good Life” in a Military Context: How Does Life and Work-Satisfaction Relate to Orientations to Happiness and Career-Success Among Swiss Professional Officers?

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    The study examines work- and life satisfaction along with orientation to happiness, and their relation to subjective but also objective career success, among Swiss military professional officers. They frequently report worsening of their working conditions due to two reforms that have recently been conducted. A total of N=221 Swiss career officers (mainly Land Forces; from Colonel to First Lieutenant) completed several questionnaires in an online survey. As expected, pleasure, engagement and meaning were positively related to satisfaction with life and the meaningful life also correlated with the (overall) work satisfaction. Higher subjective career success was related to higher satisfaction with life, content-related aspects of work satisfaction, and higher endorsements to the engaged and the meaningful life. Belonging to the general staff was considered as an objective criterion of career success and those who were in the general staff, were higher in their overall work satisfaction, content-related aspects of their work and, again, higher inclination to the life of engagement and the life of meaning. The study suggests that variables of positive psychological functioning are useful additions in the field of military psychology and that they might hold a key for the development of strategies for improving both, work- and life satisfaction among military personne

    6sterreichische Wasser- und Abfallwirtschaft / Grundlegende Erkenntnisse im Rahmen des Pilotprojekt Bad Deutsch-Altenburg : Die Bedeutung der Stromsohle und Uferzonen f\ufcr \uf6kologische Prozesse und Artengemeinschaften an einem stark regulierten Fluss, der Donau

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    Fl\ufcsse ben\uf6tigen f\ufcr eine langfristige \uf6kologische Stabilit\ue4t \u2013 Bereiche, die bei verschiedenen Abflusssituationen als hoch produktive Lebensr\ue4ume verf\ufcgbar sind und entsprechend mit dem Fluss in Austausch stehen. Diese Retentionsbereiche oder bioaktive Zonen sind wichtig f\ufcr die flusseigene Tierwelt als Refugialr\ue4ume (z. B. Makrozoobenthos und Fische) oder bestimmte Entwicklungsstadien (z. B. Jungfische), dienen benthischen Algengemeinschaften zum Aufbau von Biomasse und sind damit Grundlage f\ufcr das Nahrungsnetz des Flusses sowie den Stoffr\ufcckhalt und Umbau (z. B. N\ue4hrstoffaufnahme). Vor allem w\ue4hrend Niederwasser sind die Uferbereiche und die Stromsohle selbst von wesentlicher Bedeutung, aber in ihrer Auspr\ue4gung durch Regulierungsma fnahmen deutlich eingeschr\ue4nkt. Ein grundlegendes Verst\ue4ndnis der Abl\ue4ufe und funktionalen Zusammenh\ue4nge ist erforderlich, damit im Rahmen von wasserbaulichen Ma fnahmen negative Konsequenzen hintangehalten werden k\uf6nnen bzw. der \uf6kologische Zustand wieder verbessert werden kann. Im Rahmen des Pilotprojekts Bad Deutsch-Altenburg an der Donau \uf6stlich von Wien ist daher nicht nur ein Monitoring der flussbaulichen Ma fnahmenumsetzung erforderlich, sondern auch ein wissenschaftlicher Erkenntnisgewinn \ufcber grundlegende Zusammenh\ue4nge und biologische Abl\ue4ufe, um optimierte Ma fnahmen zum Einsatz bringen zu k\uf6nnen. In diesem Artikel werden Ergebnisse mehrj\ue4hriger Forschungsarbeiten in den Tiefenzonen der Donau und typischen Uferzonenlebensr\ue4umen f\ufcr die Organismengruppen benthische Algen, Makrozoobenthos und Fische pr\ue4sentiert.To ensure a long-term ecological stability, rivers need areas that are available at different discharge situations as highly productive habitats which are connected with the river. These retention areas or biologically active zones are important for the riverine communities as refuge (e.g. benthic macroinvertebrates and fish) or the development of benthic algae communities as basis for the riverine food web as well as retention zones to perform various ecosystem services (e.g. nutrient retention). Especially during low water level situations, the river shorelines and the river bed itself are of significant importance, but highly degraded in intensely regulated river systems such as the Danube River. A basic understanding of the processes and functional correlations is required to avoid negative consequences of engineering measures applied and to improve the ecological conditions. In the framework of the pilot project Bad Deutsch-Altenburg in the Danube River east of Vienna not only monitoring the implementation of engineering measures is required, but also scientific knowledge gained about basic ecological relationships and potential responses of riverine communities. This article presents results of several years of investigations on the distribution and development of three organism groups (benthic algae, benthic macroinvertebrates and fish) along different riparian structures and in the river bed of the Danube River

    Desarrollo de color y golpe de sol en manzano, variedades Red King Oregon y Gala

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    Resumen (Spanish, English)92 p.Se realizaron distintos grados de poda durante la temporada 1994-1996 en árboles adultos de las variedades Red King Oregon (R.K.O) y Gala, con el objeto de determinar su influencia en el desarrollo de color de la fruta. Además se midió la acumulación de antocianinas y la actividad de la enzima fenilalanina amonio liasa (PAL), con el fin de relacionarlas con el desarrollo de los frutos. También se cubrieron algunos frutos con filtros de luz a fin de determinar la importancia de la cantidad y calidad de la luz en la producción de antocianinas de ambas variedades. Por otra parte, se determinó la incidencia de golpe de sol en los diferentes tratamientos y la importancia de la luz UV en la ocurrencia del daño, mediante el uso de filtros de vidrio en algunos árboles. La influencia de la poda sobre el calor de los frutos mostró resultados poco consistentes en la var. R.K.O. Sin embargo, en el cv. Gala se obtuvieron incrementos significativos en la coloración. En cuanto a la acumulación de antocianinas, en ambas variedades se observaron dos "peaks": el primero 60 DDPF y el segundo previo a la cosecha. La evolución del pigmento no logró relacionarse con la actividad de la enzima PAL durante el desarrollo del fruto. Con respecto a la utilización de filtros pudo observarse que la var. R.K.O resultó requerir menores niveles de luz para producir antocianinas que Gala; más aún, en ésta última var. la producción del pigmento se ve altamente afectada por reducciones de la cantidad de luz que llega al fruto. No se observaron diferencias significativas con respecto a la incidencia de golpe de sol en fruta proveniente de tratamientos con o sin poda en verde, pero si se observaron diferencias en cuanto a la orientación de la fruta en el árbol, resultando más afectada la ubicada en el sector suroeste de los árboles. El uso del filtro de vidrio disminuyó considerablemente la incidencia de golpe de sol en Gala

    Ganadería sustentable en la reserva hídrica provincial Pampa Achala. Estudio sobre la producción de camélidos sudamericanos domésticos. Proyecto de conservación de la biodiversidad (TF-028372), subcomponente desarrollo de actividades sustentables

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    El objetivo general de este proyecto es demostrar la factibilidad de implementar una producción sustentable CSD (Llamas) en la reserva Hídrica Provincial de Pampa de Achala (RHPPA). Los objetivos específicos son: • Medir la adaptación de los CSD a los hábitos de producción de los pobladores del área de estudio. • Medir la calidad de la fibra obtenida mediante procesamientos textiles artesanales e industriales • Evaluar la calidad de la carne mediante la realización de faenas protocolizadas y análisis de calidad. • Analizar el desempeño productivo de un plantel experimental de CSD teniendo en cuenta la sustentabilidad. • Desarrollar criterios a través de los cuales se puedan fijar los requisitos técnicos para diseñar un certificado de calidad de producción orgánica para fibra y para carne. Se trabajará con dos planteles experimentales: en la zona de influencia de la Escuela Martín Fierro, y en el Cerro El Lindero en Yacanto-San Javier. Se totalizarán 30 animales por cada lugar y se controlará el manejo y el procesamiento de los productos: fibra y carne. El estudio de la artesanía tradicional y la recuperación de las técnicas tradicionales de los artesanos de la zona será otra actividad importante de este proyect

    BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma

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    Type II germ cell cancers (GCC) can be subdivided into seminomas and non-seminomas. Seminomas are similar to carcinoma in situ (CIS) cells, the common precursor of type II GCCs, with regard to epigenetics and expression, while embryonal carcinomas (EC) are totipotent and differentiate into teratomas, yolk-sac tumors and choriocarcinomas. GCCs can present as seminomas with a non-seminoma component, raising the question if a CIS gives rise to seminomas and ECs at the same time or whether seminomas can be repro- grammed to ECs. In this study, we utilized the seminoma cell line TCam-2 that acquires an EC-like status after xenografting into the murine flank as a model for a seminoma to EC tran- sition and screened for factors initiating and driving this process. Analysis of expression and DNA methylation dynamics during transition of TCam-2 revealed that many pluripotency- and reprogramming-associated genes were upregulated while seminoma-markers were downregulated. Changes in expression level of 53 genes inversely correlated to changes in DNA methylation. Interestingly, after xenotransplantation 6 genes ( GDF3 , NODAL , DNMT3B , DPPA3 , GAL , AK3L1 ) were rapidly induced, followed by demethylation of their genomic loci, suggesting that these 6 genes are poised for expression driving the repro- gramming. We demonstrate that inhibition of BMP signaling is the initial event in reprogram- ming, resulting in activation of the pluripotency-associated genes and NODAL signaling. We propose that reprogramming of seminomas to ECs is a multi-step process. Initially, the microenvironment causes inhibition of BMP signaling, leading to induction of NODAL sig- naling. During a maturation phase, a fast acting NODAL loop stimulates its own activity and temporarily inhibits BMP signaling. During the stabilization phase, a slow acting NODAL loop, involving WNTs re-establishes BMP signaling and the pluripotency circuitry. In parallel, DNMT3B-driven de novo methylation silences seminoma-associated genes and epigenetically fixes the EC state

    Gene expression signatures of pathways alterations in tumor cells caused by plant extracts

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    Extracts of Viscum album from different host trees (Iscador®Qu, M, P and A) and isolated mistletoe lectin showed distinct gene-expression profiles using cDNA microarrays. We were able to confirm that genes of apoptosis, the cell cycle and the immune system were affected by mistletoe preparations and we also found that signal transduction, cell communication and cancer related pathways were overregulated in the tested breast cancer (HCC-1937, MCF-7, KPL-1, Mfm-223) and lymphoma cell lines (WSZ-NHL). The effect of a specific mistletoe extract on a particular cell line was individual, so that the distinction between the reaction of the cell type and/or the influence of the mistletoe preparation could be used in targeted mistletoe therapy
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