Addendum to: "The Bolzano-Weierstrass theorem is the jump of weak Konig's lemma" [Ann. Pure Appl. Logic 163 (6) (2012) 623-655]

The purpose of this addendum is to close a gap in the proof of [1, Theorem 11.2], which characterizes the computational content of the Bolzano\u2013Weierstra f Theorem for arbitrary computable metric spaces

Impedance measurements and simulations on the TCT and TDI LHC collimators

The LHC collimation system is a critical element for the safe operation of the LHC machine and it is subject to continuous performance monitoring, hardware upgrade and optimization. In this work we will address the impact on impedance of the upgrades performed on the injection protection target dump (TDI), where the absorber material has been changed to mitigate the device heating observed in machine operation, and on selected secondary (TCS) and tertiary (TCT) collimators, where beam position monitors (BPM) have been embedded for faster jaw alignment. Con- cerning the TDI, we will present the RF measurements per- formed before and after the upgrade, comparing the result to heating and tune shift beam measurements. For the TCTs, we will study how the higher order modes (HOM) intro- duced by the BPM addition have been cured by means of ferrite placement in the device. The impedance mitigation campaign has been supported by RF measurements whose results are in good agreement with GdfidL and CST simula- tions. The presence of undamped low frequency modes is proved not to be detrimental to the safe LHC operation

Enhancing supply chain resilience through the supply network approach

Purpose This study aims to investigate the efficacy of the supply network approach in bolstering supply chain resilience amidst escalating global uncertainty. With enterprises worldwide facing increasing threats that disrupt supply chains, this research explores how firms enhance supply network resilience during crises. Design/methodology/approach Using a multi-case study design, this research thoroughly examines interactions within firms’ supply networks to uncover new insights on supply network approach and how firms enhance supply network resilience against global uncertainty. The selection of cases was methodologically aligned to represent diverse industries and geographical locations to ensure a comprehensive analysis. Findings This study’s findings reveal how firms develop supply network resilience during global crises. The supply network perspective provides a deeper understanding of how firms manage supply chain interactions, interdependencies and strategic positions to survive and thrive during crises. The conceptual framework developed here provides insights that can foster improved coordination and facilitate effective temporary organising. The framework highlights the need for firms to proactively seize opportunities and mitigate risks within their global supply chains during crises to boost overall resilience. Originality/value Offering novel insights into the domain of supply chain networks, this study underscores novel perspectives of the supply network approach when firms develop supply chain resilience during global crises. Highlighting the adaptive responses of firms that integrate these approaches enriches the understanding of strategic manoeuvres firms can use to navigate global uncertainty and secure supply chain continuity

The role of third actors in the dyadic business relationship initiation: an empirical perspective of sommelier in the wine context

Purpose Starred restaurants, as significant outlets for small wineries, present a unique business opportunity. In this context, the sommelier, as a third actor, assumes a pivotal role in shaping the business relationships between these entities. This study, employing a grounded theory approach, delves into the sommeliers’ roles and activities in the initiation of relationships between small wineries and starred restaurants. Design/methodology/approach A qualitative methodology was adopted. Twenty-four semi-structured interviews, direct observations, and informal conversations with starred restaurants, small wineries, and sommeliers were collected and analysed using an abductive approach. Findings The findings suggest that the sommelier acts as a contributor to the business relationship initiation between the small winery and the starred restaurant, performing several continuous, simultaneous, and bilateral roles toward both actors. Originality/value The study sheds light on the role of wine stewards in the B2B context and provides useful insights to close the theoretical gap between business relationship initiation and the role of third actors

OC39 – The efficacy of a participatory approach in reducing pain related to venepuncture in children

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Asymmetric Total Synthesis of (−)‐Glycybridin B, a Pharmacophore Screened Candidate for Tubulin Binding

Microtubule-targeting agents (MTAs) represent a pivotal class of therapeutic compounds designed to disrupt microtubule dynamics, leading to cell cycle arrest and apoptosis in malignant cells. Nevertheless, their off-target effects on healthy, rapidly dividing cells result in significant neurotoxicity and myelosuppression. Ongoing research aims to enhance their specificity and identify novel active scaffolds to minimize adverse effects and fight drug resistance. Searching for new potential tubulin binders with a pharmacophore screening method, we identified glycybridin B as a promising natural product. Here, we report the first total synthesis of this compound via a five-step route, involving a key chalcone intermediate, along with its biological evaluation

Joint ICES/EUROMARINE: Workshop on common conceptual mapping methodologies (WKCCMM; Outputs from 2021 meeting)

The Joint ICES/EUROMARINE Workshop on Common Conceptual Mapping Methodologies (WKCCMM) aimed to advance approaches to support inter- and transdisciplinary science via qualitative conceptual models to inform Integrated Ecosystem Assessment (IEA) throughout Eu-ropean seas and beyond. The workshop focused on developing a common understanding of conceptual mapping meth-odologies, their key uses and limitations, and processes for effective conceptual modelling with stakeholders for a variety of applications (e.g. developing food-webs, socio-ecological modelling, scoping exercises, rapid/initial management action and/or impact evaluations). Discussion in-volved presentation and discussion of a range of conceptual modelling approaches and contexts through the examination of case studies. These case studies gave rise to a suite of recommenda-tions, including the development of a workflow for IEA, and more generic guidelines and best practice advice for the use of conceptual modelling approaches with stakeholders. Although stakeholders were not able to be included in this workshop, they were very much at the heart of discussions, with the challenges and good practices of stakeholder inclusion addressed. WKCCMM also investigated how the methodologies can be best used to contribute to IEA, and may otherwise be applied throughout the ICES community, including identifying opportunities for cross-collaboration and knowledge transfer within the network.info:eu-repo/semantics/publishedVersio