McKean–Vlasov limit for interacting systems with simultaneous jumps

Motivated by several applications, including neuronal models, we consider the McKean–Vlasov limit for a general class of mean-field systems of interacting diffusions characterized by an interaction via simultaneous jumps. We focus our interest on systems where the rate of the jumps is unbounded, which are rarely treated in the mean-field literature, and we prove well-posedness of the McKean–Vlasov limit together with propagation of chaos via a coupling technique. To highlight the role of simultaneous jumps, we introduce an intermediate process which is close to the original particle system but does not display simultaneous jumps. This shows in particular that the simultaneous jumps contribute to the overall rate of convergence of the N-particle empirical measures by a term of order 1/√N

Multidimensional extensions of IRT models and their application to customer satisfaction evaluation

Multidimensional IRT models (MIRTM), developed in the fields of psychometrics and ability assessment, are here considered in connection with the problem of evaluating customer satisfaction. Different models, that allow us to take into account more complex and, possibly, more realistic latent constructs than those usually assumed, are presented and discussed. Eventually, these models are applied to a real dataset, MCMC techniques for the estimation are implemented and analogies and differences with results from previous analyses on the same survey in the literature are discussed

Combination of letrozole, metronomic cyclophosphamide and sorafenib is well-tolerated and shows activity in patients with primary breast cancer

PURPOSE: To assess whether the combination of letrozole, metronomic cyclophosphamide and sorafenib (LCS) is well tolerated and shows activity in primary breast cancer (BC). METHODS:Thirteen oestrogen receptor-positive, postmenopausal, T2-4, N0-1 BC patients received the LCS combination for 6 months. In these patients we examined the pharmacokinetics of sorafenib and cyclophosphamide, toxicity of the regimen, the clinical response to therapy and changes in the levels of biologically relevant biomarkers. RESULTS:Adequate plasma concentrations of sorafenib were achieved in patients when it was dosed in combination with L+C. The mean plasma concentrations of C were consistently lower following administration of LCS, compared with administration of L+C only. The most common drug-related grade 3/4 adverse events were skin rash (69.3%), hand-foot skin reaction (69.3%) and diarrhoea (46.1%). According to RECIST Criteria, a clinical complete response was observed in 6 of 13 patients. A significant reduction in tumour size, evaluated with MRI, was also observed between baseline and 14 days of treatment in all 13 patients (P=0.005). A significant reduction in SUV uptake, measured by (18)FDG-PET/CT, was observed in all patients between baseline and 30 days of treatment (P=0.015) and between baseline and definitive surgery (P=0.0002). Using modified CT Criteria, a response was demonstrated in 8 out of 10 evaluable patients at 30 days and in 11 out of 13 evaluable patients at the definitive surgery. A significant reduction in Ki67 expression was observed in all patients at day 14 compared with baseline (P<0.00001) and in 9 out of 13 patients at the definitive surgery compared with baseline (P<0.03). There was also a significant suppression of CD31 and VEGF-A expression in response to treatment (P=0.01 and P=0.007, respectively).CONCLUSIONS:The LCS combination is feasible and tolerable. The tumour response and target biomarker modulation indicate that the combination is clinically and biologically active

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

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The spatial structure of lithic landscapes : the late holocene record of east-central Argentina as a case study

Fil: Barrientos, Gustavo. División Antropología. Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; ArgentinaFil: Catella, Luciana. División Arqueología. Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; ArgentinaFil: Oliva, Fernando. Centro Estudios Arqueológicos Regionales. Facultad de Humanidades y Artes. Universidad Nacional de Rosario; Argentin