La poesia a teatro: una lettura del Libro di Ipazia di Mario Luzi.

Il mio lavoro di tesi ha come obiettivo l’analisi della prima opera teatrale, Libro di Ipazia, realizzata dal poeta fiorentino Mario Luzi. Mario Luzi non è stato uomo di teatro in senso “tecnico”, ma soprattutto uomo di poesia e questo elemento non può essere trascurato se ben si vogliono comprendere tutte le dinamiche e le scelte condotte dal poeta in fase di elaborazione teatrale

The effects of arterial flow on platelet activation, thrombus growth, and stabilization

Injury of an arterial vessel wall acutely triggers a multifaceted process of thrombus formation, which is dictated by the high-shear flow conditions in the artery. In this overview, we describe how the classical concept of arterial thrombus formation and vascular occlusion, driven by platelet activation and fibrin formation, can be extended and fine-tuned. This has become possible because of recent insight into the mechanisms of: (i) platelet-vessel wall and platelet-platelet communication, (ii) autocrine platelet activation, and (iii) platelet-coagulation interactions, in relation to blood flow dynamics. We list over 40 studies with genetically modified mice showing a role of platelet and plasma proteins in the control of thrombus stability after vascular injury. These include multiple platelet adhesive receptors and other junctional molecules, components of the ADP receptor signalling cascade to integrin activation, proteins controlling platelet shape, and autocrine activation processes, as well as multiple plasma proteins binding to platelets and proteins of the intrinsic coagulation cascade. Regulatory roles herein of the endothelium and other blood cells are recapitulated as well. Patient studies support the contribution of platelet- and coagulation activation in the regulation of thrombus stability. Analysis of the factors determining flow-dependent thrombus stabilization and embolus formation in mice will help to understand the regulation of this process in human arterial diseas

The Multi-purpose Crew Vehicle European Service Module: a European Contribution to Human Exploration

This paper provides an overview of the system and subsystem configuration of the MPCV European Service Module (ESM) at Preliminary Design Review (PDR) stage as well as its perspectives of utilisation within the global space exploration endeavour. The MPCV ESM is a cylindrical module with a diameter of 4500 mm and a total length main engine excluded of 2700 mm. It is fitted with four solar array wings with a span of 18.8 m. Its dry mass is 3.5 metric tons and it can carry 8.6 tons of propellant. The main functions of the European Service Module are to bring the structural continuity between the launcher and the crew module, to provide propulsion to the MPCV, to ensure its thermal control as well as electrical power and to store water, oxygen and nitrogen for the mission. The current agreement foresees the development and production by Europe of one flight model, with an option for a second one. This module will be assembled in Europe and delivered to NASA in 2016. It will be used for a flight of the MPCV Orion in December 2017

Numerical experiments in 2D variational fracture

In the present work we present some results of numerical experiments obtained with a variationalmodel for quasi-static Griffith-type brittle fracture. Essentially the analysis is based on a recent formulation byFrancfort and Marigo the main difference being the fact that we rely on local rather than on globalminimization. Propagation of fracture is obtained by minimizing, in a step by step process, a form of energythat is the sum of bulk and interface terms. To solve the problem numerically we adopt discontinuous finiteelements based on variable meshes and search for the minima of the energy through descent methods. We use asort of mesh dependent relaxation of the interface energy to get out of small energy wells. The relaxationconsists in the adoption of a carefully tailored cohesive type interface energy, tending to the Griffith limit as themesh size tends to zero

Thyroid dysfunction and anaemia in a large population-based study.

OBJECTIVE AND BACKGROUND: Anaemia and thyroid dysfunction are common and often co-occur. Current guidelines recommend the assessment of thyroid function in the work-up of anaemia, although evidence on this association is scarce. PATIENTS AND METHODS: In the 'European Prospective Investigation of Cancer' (EPIC)-Norfolk population-based cohort, we aimed to examine the prevalence and type of anaemia (defined as haemoglobin <13 g/dl for men and <12 g/dl for women) according to different thyroid function groups. RESULTS: The mean age of the 8791 participants was 59·4 (SD 9·1) years and 55·2% were women. Thyroid dysfunction was present in 437 (5·0%) and anaemia in 517 (5·9%) participants. After excluding 121 participants with three most common causes of anaemia (chronic kidney disease, inflammation, iron deficiency), anaemia was found in 4·7% of euthyroid participants. Compared with the euthyroid group, the prevalence of anaemia was significantly higher in overt hyperthyroidism (14·6%, P < 0·01), higher with borderline significance in overt hypothyroidism (7·7%, P = 0·05) and not increased in subclinical thyroid dysfunction (5·0% in subclinical hypothyroidism, 3·3% in subclinical hyperthyroidism). Anaemia associated with thyroid dysfunction was mainly normocytic (94·0%), and rarely macrocytic (6·0%). CONCLUSION: The prevalence of anaemia was higher in overt hyperthyroidism, but not increased in subclinical thyroid dysfunction. Systematic measurement of thyroid-stimulating hormone in anaemic patients is likely to be useful only after excluding common causes of anaemia

Transcriptional mechanism of vascular endothelial growth factor-induced expression of protein kinase CβII in chronic lymphocytic leukaemia cells

A key feature of chronic lymphocytic leukaemia (CLL) cells is overexpressed protein kinase CβII (PKCβII), an S/T kinase important in the pathogenesis of this and other B cell malignancies. The mechanisms contributing to enhanced transcription of the gene coding for PKCβII, PRKCB, in CLL cells remain poorly described, but could be important because of potential insight into how the phenotype of these cells is regulated. Here, we show that SP1 is the major driver of PKCβII expression in CLL cells where enhanced association of this transcription factor with the PRKCB promoter is likely because of the presence of histone marks permissive of gene activation. We also show how vascular endothelial growth factor (VEGF) regulates PRKCB promoter function in CLL cells, stimulating PKCβ gene transcription via increased association of SP1 and decreased association of STAT3. Taken together, these results are the first to demonstrate a clear role for SP1 in the up regulation of PKCβII expression in CLL cells, and the first to link SP1 with the pathogenesis of this and potentially other B cell malignancies where PKCβII is overexpressed

An Analysis of the Influence that Community Demographic Data have on Student Performance on 2012 NJASK 8 Language Arts and Mathematics

This correlational, explanatory, cross-sectional quantitative study intended to analyze the influence that community demographic factors had on student performance on the 2012 Grade 8 New Jersey Assessment of Skills and Knowledge (NJ ASK). The data that were analyzed were procured from the New Jersey Department of Education website as well as the U.S. Census Bureau’s American Factfinder. The sample size included all New Jersey school districts with an eighth grade population of 25 or more students. This ultimately equated to a sample size of N = 409. The studied explored the community demographic variables that explained the greatest amount of variance on students scoring Advanced Proficient and Proficient on the 2012 NJ ASK 8 Language Arts and Mathematics. The statistical analysis showed that three independent variables (predictors) explained the greatest amount of variance on student performance in both Language Arts and Mathematics: no high school diploma, all people under poverty level, and employment status. Language Arts scores related an R-square value of 67.2% with a margin of error of +/- 7.1 and Mathematics had an R-square value of 63.2% with a margin of error of +/- 9.8 when the independent variables were analyzed. The statistically significant variables combined to accurately predict the percentage of students scoring Proficient or Advanced Proficient in 89.0% of school districts on the Language Arts section of the 2012 NJ ASK 8 and 89.2% of school districts on the Mathematics section of the 2012 NJ ASK 8. This predictive power is remarkable and provides data that demonstrate undeniably that student performance is strongly influenced by factors that abrogate from teaching and learning in the classroom. The results from this study revealed that community demographic factors influenced student results on the 2012 NJ ASK 8