Urban generosity: design strategies for an architecture of liveability

As practice based research, this exegesis is a dissemination of design strategies embedded in the process termed Urban Generosity. The beginning of the twentieth first century has seen the rise of greater populations within cities creating new demands on the form and structure of cities. This proliferation of human activity has given rise to the nature of cities, a place of exchange and surplus, a place of urban generosity. This research has observed how local conditions can readily be shifted given our global assertion of liveability and governance, with either detrimental or enhancing outcomes, on the long-term generosity of the city. Through observation it is proposed that urban generosity is active, it facilitates a series of design responses that transcends architectural iconic object making through a series of subtle design devices. Urban generosity is the investigation of an architecture that authenticates the local context and allows the imagination of others to delight within a given context. It is fundamentally about clothing that culture and its binding civic effect that extends the individual site into a wider context harnessing the forces of globalisation to develop a civic surplus. The design investigations have developed around the key question of how architecture can extend itself beyond a mid-twentieth century form/ function paradigm? What opportunities does architecture offer the environment in which it is placed

Geoarqueologia i micromorfologia de l'Abric de La Cativera (El Catllar, Tarragona): noves dades sobre el límit Pleistocè-Holocè al nordest de la Península Ibèrica

L'abric de La Cativera (Tarragona) conté una successió estratigràfica gairebé contínua i intensarnent antropitzada que cobreix l'interval cronològic Tardiglacial-Holoce antic. Les anàlisis geoarqueològiques i rnicromorfològiques detallades del registre del jaciment ens permeten conèixer els canvis paleoambientals al voltant deIs 10 000 anys BP. Se subratllen les importants modificacions morfodinàmiques del Dryas Recent, el gradual apropament al clima mediterrani durant I'Holoce antic i la definitiva fase de biostasia de l'Holoce recent. S'analitzen així mateix els caracters de l'impacte antropic, on destaca la presencia de fragments ceràmics datats en el Boreal.The La Cativera rockshelter (Tarragona, NE Spain) contains an almost continuous, archaeologically rich succession spanning from the Lateglacial to the early Holocene. The geoarchaeological and detailed micromorphological analyses of the site record allow us focusing the environmental changes around 10 ka BP. The intense morphodynarnic modifications of the Younger Dryas, the gradual fluctuations towards the Mediterranean clirnate in the early Holocene and the definite stable phase during the younger Holocene are noticeable. The anthropic record at the site is analysed as well, particularly remarking the presence of ceramic shards dated to the Boreal zone

Dynamic test/analysis correlation using reduced analytical models

Test/analysis correlation is an important aspect of the verification of analysis models which are used to predict on-orbit response characteristics of large space structures. This paper presents results of a study using reduced analysis models for performing dynamic test/analysis correlation. The reduced test-analysis model (TAM) has the same number and orientation of DOF as the test measurements. Two reduction methods, static (Guyan) reduction and the Improved Reduced System (IRS) reduction, are applied to the test/analysis correlation of a laboratory truss structure. Simulated test results and modal test data are used to examine the performance of each method. It is shown that selection of DOF to be retained in the TAM is critical when large structural masses are involved. In addition, the use of modal test results may provide difficulties in TAM accuracy even if a large number of DOF are retained in the TAM

Development of a Background-Oriented Schlieren Technique with Telecentric Lenses for Supersonic Flow

Background oriented schlieren (BOS) is a quantitative optical technique which exploits light deflection occurring in non-homogeneous transparent media. It allows to indirectly measure the density gradients by analysing the apparent displacement of features of a background pattern when imaged through the investigated flow. Thanks to its simple set-up and to the consolidated data reduction technique based on cross-correlation algorithms the BOS technique has progressively attracted the interest of the researchers. In this work a BOS system using a telecentric lens system has been set up in order to improve measurement accuracy and to avoid 3D effects arising from using conventional entocentric lenses. The design of the telecentric lens system is reported along with an analysis of its performance in term of spatial resolution. Some preliminary tests on a supersonic flows are also reported

The Determinants of Privatised Enterprise Performance in Russia

Using data from a large enterprise-level panel designed to address this issue, we account for enterprise performance in Russia. We link performance to four aspects of the economic environment: enterprise ownership; corporate governance; market structures and competition; and financial constraints. We conclude that private ownership and improved performance are not correlated, though restructuring is positively associated with the competitiveness of the market environment. These findings on private ownership support those of previous studies, e.g. Earle and Estrin (1997). Moreover, we find evidence that financially unconstrained firms are better in their undertaking of restructuring measures then financially constrained firms. Further analysis suggests that causality runs from restructuring to financial constraint, rather than the reverse. Finally, our findings indicate strong complementarities between the four factors influencing improved company performance, confirming the view that these factors need to be considered jointly.Privatisation, enterprise performance, competition, corporate governance, investment

Formation processes at a high resolution Middle Paleolithic site: Cueva Antón (Murcia, Spain)

Cueva Antón is a Middle Paleolithic rockshelter located in the valley of the River Mula (Murcia, Spain). The archeological investigation of the site, which began with salvage work in 1991, resumed in 2006 and is still ongoing, uncovered a succession spanning most of MIS 3 and MIS 4 (ca. 75e36 ka) and featuring a well preserved human occupation record. This paper presents the first information about site stratigraphy and site formation processes. Geoarcheological data collected in the field and through micromorphological observation show that the archeological succession at Cueva Antón is mainly composed of alluvial sediments, with thin intercalations of gravitational and slope material. The sedimentary characteristics of the alluvial succession are well preserved as the result of a rapid accumulation rate and the protective effect of the rockshelter. Several sedimentary facies produced by the shifting of distinct fluvial sub-environments (channel, bar and floodplain) are recognized. With the exception of a few units (II-u, a thin buried alluvial soil, and the archeologically richest units at the base of the succession), postdepositional modification is rare. The site was occupied within a framework of infrequent, short-term visits, resulting in a relatively low overall density of finds and the formation of well-defined archeological lenses that correspond to synchronous paleosurfaces preserving the spatial distribution of finds and features. This pattern explains the limited anthropogenic evidence observed in thin sections, even those from units where archeological excavation uncovered significant remains of human occupation

Inhibition of acetylpolyamine and spermine oxidases by the polyamine analogue chlorhexidine

""Acetylpolyamine and spermine oxidases are involved in the catabolism of polyamines. The discovery of selective. inhibitors of these enzymes represents an important tool for the development of novel anti-neoplastic drugs. Here, a. comparative study on acetylpolyamine and spermine oxidases inhibition by the polyamine analogue chlorhexidine. is reported. Chlorhexidine is an antiseptic diamide, commonly used as a bactericidal and bacteriostatic agent.. Docking simulations indicate that chlorhexidine binding to these enzymes is compatible with the stereochemical. properties of both acetylpolyamine oxidase and spermine oxidase active sites. In fact, chlorhexidine is predicted. to establish several polar and hydrophobic interactions with the active site residues of both enzymes, with binding. energy values ranging from −7.6 to −10.6 kcal\\\/mol. In agreement with this hypothesis, inhibition studies indicate that. chlorhexidine behaves as a strong competitive inhibitor of both enzymes, values of Ki being 0.10 μM and 0.55 μM for. acetylpolyamine oxidase and spermine oxidase, respectively."

La ocupación solutrense del Abrigo de la Boja (Mula, Murcia, España)

El relleno pleistoceno del Abrigo de la Boja (ADB) empieza con un nivel adscrito al Magdaleniense superior, seguido de un potente paquete con ocupación difusa bajo el cual se desarrolla una secuencia depositada durante el último máximo glacial caracterizada por una serie de estructuras de combustión, de tipo hogar plano/amorfo (open hearth), existiendo también hogares de cubeta. Destaca un hogar enlosado, completo y muy bien conservado, excavado en 2012 y adscrito provisionalmente al Solutreogravetiense. Los niveles solutrenses subyacentes son ricos en elementos de adorno, entre los cuales conchas perforadas de Littorina obtusata y Smaragdia viridis; su industria lítica incluye raspadores, algunas puntas, y escasos buriles. La datación 14C de muestras de carbón de Juniperus sp. sitúa este paquete entre 16990 ± 70 BP (VERA-5364a), a techo, y 20980 ± 120 BP (VERA-5366), a muro. The Pleistocene fill of the La Boja rock shelter (ADB) starts with an Upper Magdalenian level, followed by a thick package with poorly defined occupations under which there is a Last Glacial Maximum sequence with combustion features, mostly of the open hearth type. A particularly well preserved and seemingly complete stone-paved hearth of probable Solutreogravettian age was excavated in 2012. The abundant ornaments in the Solutrean levels include pierced Littorina obtusata and Smaragdia viridis shells and the stone tool assem- blages feature endscrapers, some points and rare burins. The 14C dating of Juniperus sp. charcoal samples places this sequence between 16990 ± 70 BP (VERA-5364a), at the top, and 20980 ± 120 BP (VERA-5366), at the bottom

Fragment-based discovery of a regulatory site in thioredoxin glutathione reductase acting as "doorstop" for NADPH entry

Members of the FAD/NAD-linked reductase family are recognized as crucial targets in drug development for cancers, inflammatory disorders, and infectious diseases. However, individual FAD/NAD reductases are difficult to inhibit in a selective manner with off target inhibition reducing usefulness of identified compounds. Thioredoxin glutathione reductase (TGR), a high molecular weight thioredoxin reductase-like enzyme, has emerged as a promising drug target for the treatment of schistosomiasis, a parasitosis afflicting more than 200 million people. Taking advantage of small molecules selected from a high-throughput screen and using X-ray crystallography, functional assays, and docking studies, we identify a critical secondary site of the enzyme. Compounds binding at this site interfere with well-known and conserved conformational changes associated with NADPH reduction, acting as a doorstop for cofactor entry. They selectivity inhibit TGR from Schistosoma mansoni and are active against parasites in culture. Since many members of the FAD/NAD-linked reductase family have similar catalytic mechanisms the unique mechanism of inhibition identified in this study for TGR broadly opens new routes to selectively inhibit homologous enzymes of central importance in numerous diseases