Jejunal Perforation During Percutaneous Nephrolithotrypsy

Colonic and duodenal perforations, albeit rare, are known complications of PCNL; however, to our knowledge, jejunal perforation has never been reported. We report a case of an 83-year-old man, underwent left PCNL for a 2cm stone in the renal pelvis, confirmed to have a jejunal perforation. He was successfully managed conservatively. His diagnostic work up and management will be discussed

Long Term Stabilization of Expanding Aortic Aneurysms by a Short Course of Cyclosporine A through Transforming Growth Factor-Beta Induction

Abdominal aortic aneurysms (AAAs) expand as a consequence of extracellular matrix destruction, and vascular smooth muscle cell (VSMC) depletion. Transforming growth factor (TGF)-beta 1 overexpression stabilizes expanding AAAs in rat. Cyclosporine A (CsA) promotes tissue accumulation and induces TGF -beta1 and, could thereby exert beneficial effects on AAA remodelling and expansion. In this study, we assessed whether a short administration of CsA could durably stabilize AAAs through TGF-beta induction. We showed that CsA induced TGF-beta1 and decreased MMP-9 expression dose-dependently in fragments of human AAAs in vitro, and in animal models of AAA in vivo. CsA prevented AAA formation at 14 days in the rat elastase (diameter increase: CsA: 131.9±44.2%; vehicle: 225.9±57.0%, P = 0.003) and calcium chloride mouse models (diameters: CsA: 0.72±0.14 mm; vehicle: 1.10±0.11 mm, P = .008), preserved elastic fiber network and VSMC content, and decreased inflammation. A seven day administration of CsA stabilized formed AAAs in rats seven weeks after drug withdrawal (diameter increase: CsA: 14.2±15.1%; vehicle: 45.2±13.7%, P = .017), down-regulated wall inflammation, and increased αSMA-positive cell content. Co-administration of a blocking anti-TGF-beta antibody abrogated CsA impact on inflammation, αSMA-positive cell accumulation and diameter control in expanding AAAs. Our study demonstrates that pharmacological induction of TGF-beta1 by a short course of CsA administration represents a new approach to induce aneurysm stabilization by shifting the degradation/repair balance towards healing

Comparison of vasovasostomy with conventional microsurgical suture and fibrin adhesive in rats

OBJECTIVE: Microsurgical procedures are currently the gold standard for vasovasostomy with excellent results, but it takes an increased operative time demanding special training and experience in microsurgery. The objective of this study is to reach the same results with reduced operative time. MATERIALS AND METHODS: Male adults Wistar rats were divided into 3 groups: I) 20 rats in control group, II) 20 with conventional one-layer microsuture and III) 20 with fibrin glue. After four weeks each rat was left for two weeks with two female rats. RESULTS: The fertility rates were 80% in group I, 70% in group II and 65% in group III (p > 0.05). In group II granuloma was found in 75% of the rats, while in group III in 85% (p 0.05). Overall operative time was 41.7 &plusmn; 2.49 and 28.55 &plusmn; 1.14 minutes in groups II and III (p < 0.05) and the time to anastomosis of 24.6 &plusmn; 1.8 and 9.35 &plusmn; 0.78 minutes (p < 0.05), respectively. CONCLUSIONS: We can conclude that vasovasostomy with fibrin adhesive has the same results of the conventional microsurgery technique but with a reduced operative time and a simplified procedure

‘That’s how Muslims are required to view the world’:race, culture and belief in non-Muslims’ descriptions of Islam and science

Islam’s positioning in relation to Western ideals of individuality, freedom, women’s rights and democracy has been an abiding theme of sociological analysis and cultural criticism, especially since September 11th 2001. Less attention has been paid, however, to another concept that has been central to the image of Western modernity: science. This article analyzes comments about Islam gathered over the course of 117 interviews and 13 focus groups with non-Muslim members of the public and scientists in the UK and Canada on the theme of the relationship between science and religion. The article shows how participants’ accounts of Islam and science contrasted starkly with their accounts of other religious traditions, with a notable minority of predominantly non-religious interviewees describing Islam as uniquely, and uniformly, hostile to science and rational thought. It highlights how such descriptions of Islam were used to justify the cultural othering of Muslims in the West and anxieties about educational segregation, demographic ‘colonization’ and Islamist extremism. Using these data, the article argues for: 1) wider recognition of how popular understandings of science remain bound up with conceptions of Western cultural superiority; and 2) greater attentiveness to how prejudices concerning Islamic beliefs help make the idea that Muslims pose a threat to the West respectable