Web Notification Infrastructure for the ALICE O^{2}

This report explains the development of Web Notification Infrastructure for future ALICE O^{2} System by Anirudh Goel during the Summer Student Programme under the supervision of Adam Wegrzynek

A suspected case of COVID-19 vaccine (Covishield) induced Guillain Barre syndrome-a case report

Guillain Barre syndrome (GBS) is a collection of clinical syndromes that manifest as an acute inflammatory poly radiculopathy. It usually presents as an acute, non-febrile, monophonic, post infectious illness manifesting as ascending weakness and areflexia. It is an autoimmune disorder characterized by production of antibodies against the myelin and is often triggered by bacterial and viral infections, vaccines against rabies, flu and COVID-19. Here we present a case of 31 years old male with characteristic signs and symptoms of GBS possibly triggered by Covishield vaccine.</jats:p

Abstract 1243: RET and integrin crosstalk provides functional plasticity

Abstract The RET receptor tyrosine kinase is an important mediator of cell growth, proliferation, and differentiation. RET becomes activated upon formation of a complex with the glial cell-line derived neurotrophic factor (GDNF) ligand and GDNF-family receptor (GFRa), which leads to activation of multiple downstream signalling pathways, including PI3K/AKT, MEK/ERK, STAT3, and SRC. Constitutive activation of RET, through translocations or missense mutations, leads to papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC), respectively. Also, RET expression has been detected in pancreatic and breast cancers, and has been linked to increased metastatic potential. In order to clarify the underlying role of RET in tumour progression, we examined the relationship between RET and two integrin subunits, β1 (ITGB1) and β3 (ITGB3). Integrin proteins are important for cell attachment to the extracellular matrix and focal adhesion (FA) formation. Functionally, integrins are important for cell-adhesion and migration as they provide traction and leverage for cell movement. Previously, we have shown that RET is able to increase cell-migration and adhesion, and that both ITGB1 and ITGB3 are important for these processes. Here, we show that RET-mediated cell-migration is persistent over 24 hours, and that patterns of cell-adhesion fluctuate over this time, predictably representing different forces needed to move across the microenvironment. Cell-adhesion is increased upon 1 hour of GDNF treatment, but is lost between 3-12 hours of GDNF treatment. Interestingly, we observed that ITGB1 activation downstream of RET, detected by co-immunoprecipitation with paxillin, is transient, and lasts for 1 hour. Conversely, ITGB3 activation downstream of RET, detected using an active heterodimer-specific antibody, is sustained between 1-12 hours of GDNF treatment. These results demonstrate unique functional roles for ITGB1 and ITGB3 downstream of RET. We also examined the importance of signalling pathways downstream of RET for integrin activation, and found that, in a 2D collagen environment, PI3K/AKT and MEK/ERK are important for RET-mediated FA formation. However, in a 3D collagen environment where cells formed spheroids, PI3K/AKT and STAT3 are important for cell-outgrowth, downstream of RET activation. This likely represents different cellular responses needed to overcome environment-specific obstacles. Finally, we showed evidence for a relationship between RET, ITGB1 and ITGB3 in tumour progression using a cohort of various clinically annotated thyroid cancer samples. Ultimately, we have shown a role for in activation of two integrin subunits, ITGB1 and ITGB3, downstream of RET and how each of these proteins may contribute to metastatic events, particularly those involved in thyroid cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1243. doi:1538-7445.AM2012-1243</jats:p

Automated Vehicle Security System using Convolutional Neural Networks and Support Vector Machine

With the rise in the infrastructure in the global economy, there is a need to impact the growth of security systems such as enhancing the security of vehicles at public places, societies or places with crowd. This could be done by keeping up with the monitoring of vehicles through vehicle License Plate Recognition (LPR). Since the numbers of vehicles are increasing on road day by day, it is essential to bring automation in its detection and recognition procedure. The objective of this presented work is to model a real time application to recognize license plate from a vehicle at parking of any society or public places via surveillance cameras. This paper mainly focuses on implementing the concept of component security which is marked by the presence of a blended system with car license plate recognizer as well as face recognizer recognizing its real owner. In proposed Automated Vehicle Security System (AVSS), the achievable model accuracy for Automated LPR model is 94% marked with the use of Tyserract for character recognition and model accuracy for facial recognition is raised to a mark of 83%. This model provides remarkable results and a need of another system where the owner or permitted drivers for a vehicle are mapped to vehicle license plate which could be made to use as collaboration to make it a real life deployable application.</jats:p