Patched Knockout Mouse Models of Basal Cell Carcinoma

Basal cell carcinoma (BCC) is the most common human tumor. Mutations in the hedgehog (HH) receptor Patched (PTCH) are the main cause of BCC. Due to their high and increasing incidence, BCC are becoming all the more important for the health care system. Adequate animal models are required for the improvement of current treatment strategies. A good model should reflect the situation in humans (i.e., BCC initiation due to Ptch mutations on an immunocompetent background) and should allow for (i) BCC induction at a defined time point, (ii) analysis of defined BCC stages, and (iii) induction of BCC in 100% of animals. In addition, it should be easy to handle. Here, we compare several currently existing conventional and conditional Ptch knockout mouse models for BCC and their potential use in preclinical research. In addition, we provide new data using conditional Ptch (flox/flox) mice and the K5-Cre-ER (T+/−) driver

Calcitriol Inhibits Hedgehog Signaling and Induces Vitamin D Receptor Signaling and Differentiation in the Patched

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Aberrant Hedgehog (Hh) signaling is characteristic of the embryonal subtype (ERMS) and of fusion-negative alveolar RMS. In the mouse, ERMS-like tumors can be induced by mutations in the Hh receptor Patched1 (Ptch). As in humans these tumors show increased Hh pathway activity. Here we demonstrate that the treatment with the active form of vitamin D(3), calcitriol, inhibits Hh signaling and proliferation of murine ERMS in vivo and in vitro. Concomitantly, calcitriol activates vitamin D receptor (Vdr) signaling and induces tumor differentiation. In addition, calcitriol inhibits ERMS growth in Ptch-mutant mice, which is, however, a rather late response. Taken together, our results suggest that exogenous supply of calcitriol could be beneficial in the treatment of RMS, especially in those which are associated with aberrant Hh signaling activity

Translation, interpreting, cognition: The way out of the box

Cognitive aspects of the translation process have become central in Translation and Interpreting Studies in recent years, further establishing the field of Cognitive Translatology. Empirical and interdisciplinary studies investigating translation and interpreting processes promise a hitherto unprecedented predictive and explanatory power. This collection contains such studies which observe behaviour during translation and interpreting. The contributions cover a vast area and investigate behaviour during translation and interpreting – with a focus on training of future professionals, on language processing more generally, on the role of technology in the practice of translation and interpreting, on translation of multimodal media texts, on aspects of ergonomics and usability, on emotions, self-concept and psychological factors, and finally also on revision and post-editing. For the present publication, we selected a number of contributions presented at the Second International Congress on Translation, Interpreting and Cognition hosted by the Tra&Co Lab at the Johannes Gutenberg University of Mainz

Translation, interpreting, cognition: The way out of the box

Cognitive aspects of the translation process have become central in Translation and Interpreting Studies in recent years, further establishing the field of Cognitive Translatology. Empirical and interdisciplinary studies investigating translation and interpreting processes promise a hitherto unprecedented predictive and explanatory power. This collection contains such studies which observe behaviour during translation and interpreting. The contributions cover a vast area and investigate behaviour during translation and interpreting – with a focus on training of future professionals, on language processing more generally, on the role of technology in the practice of translation and interpreting, on translation of multimodal media texts, on aspects of ergonomics and usability, on emotions, self-concept and psychological factors, and finally also on revision and post-editing. For the present publication, we selected a number of contributions presented at the Second International Congress on Translation, Interpreting and Cognition hosted by the Tra&Co Lab at the Johannes Gutenberg University of Mainz

Translation, interpreting, cognition: The way out of the box

Cognitive aspects of the translation process have become central in Translation and Interpreting Studies in recent years, further establishing the field of Cognitive Translatology. Empirical and interdisciplinary studies investigating translation and interpreting processes promise a hitherto unprecedented predictive and explanatory power. This collection contains such studies which observe behaviour during translation and interpreting. The contributions cover a vast area and investigate behaviour during translation and interpreting – with a focus on training of future professionals, on language processing more generally, on the role of technology in the practice of translation and interpreting, on translation of multimodal media texts, on aspects of ergonomics and usability, on emotions, self-concept and psychological factors, and finally also on revision and post-editing. For the present publication, we selected a number of contributions presented at the Second International Congress on Translation, Interpreting and Cognition hosted by the Tra&Co Lab at the Johannes Gutenberg University of Mainz

Translation, interpreting, cognition: The way out of the box

Cognitive aspects of the translation process have become central in Translation and Interpreting Studies in recent years, further establishing the field of Cognitive Translatology. Empirical and interdisciplinary studies investigating translation and interpreting processes promise a hitherto unprecedented predictive and explanatory power. This collection contains such studies which observe behaviour during translation and interpreting. The contributions cover a vast area and investigate behaviour during translation and interpreting – with a focus on training of future professionals, on language processing more generally, on the role of technology in the practice of translation and interpreting, on translation of multimodal media texts, on aspects of ergonomics and usability, on emotions, self-concept and psychological factors, and finally also on revision and post-editing. For the present publication, we selected a number of contributions presented at the Second International Congress on Translation, Interpreting and Cognition hosted by the Tra&Co Lab at the Johannes Gutenberg University of Mainz

Translation, interpreting, cognition: The way out of the box

Cognitive aspects of the translation process have become central in Translation and Interpreting Studies in recent years, further establishing the field of Cognitive Translatology. Empirical and interdisciplinary studies investigating translation and interpreting processes promise a hitherto unprecedented predictive and explanatory power. This collection contains such studies which observe behaviour during translation and interpreting. The contributions cover a vast area and investigate behaviour during translation and interpreting – with a focus on training of future professionals, on language processing more generally, on the role of technology in the practice of translation and interpreting, on translation of multimodal media texts, on aspects of ergonomics and usability, on emotions, self-concept and psychological factors, and finally also on revision and post-editing. For the present publication, we selected a number of contributions presented at the Second International Congress on Translation, Interpreting and Cognition hosted by the Tra&Co Lab at the Johannes Gutenberg University of Mainz

Translation, interpreting, cognition: The way out of the box

Cognitive aspects of the translation process have become central in Translation and Interpreting Studies in recent years, further establishing the field of Cognitive Translatology. Empirical and interdisciplinary studies investigating translation and interpreting processes promise a hitherto unprecedented predictive and explanatory power. This collection contains such studies which observe behaviour during translation and interpreting. The contributions cover a vast area and investigate behaviour during translation and interpreting – with a focus on training of future professionals, on language processing more generally, on the role of technology in the practice of translation and interpreting, on translation of multimodal media texts, on aspects of ergonomics and usability, on emotions, self-concept and psychological factors, and finally also on revision and post-editing. For the present publication, we selected a number of contributions presented at the Second International Congress on Translation, Interpreting and Cognition hosted by the Tra&Co Lab at the Johannes Gutenberg University of Mainz

Translation, interpreting, cognition: The way out of the box

Cognitive aspects of the translation process have become central in Translation and Interpreting Studies in recent years, further establishing the field of Cognitive Translatology. Empirical and interdisciplinary studies investigating translation and interpreting processes promise a hitherto unprecedented predictive and explanatory power. This collection contains such studies which observe behaviour during translation and interpreting. The contributions cover a vast area and investigate behaviour during translation and interpreting – with a focus on training of future professionals, on language processing more generally, on the role of technology in the practice of translation and interpreting, on translation of multimodal media texts, on aspects of ergonomics and usability, on emotions, self-concept and psychological factors, and finally also on revision and post-editing. For the present publication, we selected a number of contributions presented at the Second International Congress on Translation, Interpreting and Cognition hosted by the Tra&Co Lab at the Johannes Gutenberg University of Mainz

Translation, interpreting, cognition: The way out of the box

Cognitive aspects of the translation process have become central in Translation and Interpreting Studies in recent years, further establishing the field of Cognitive Translatology. Empirical and interdisciplinary studies investigating translation and interpreting processes promise a hitherto unprecedented predictive and explanatory power. This collection contains such studies which observe behaviour during translation and interpreting. The contributions cover a vast area and investigate behaviour during translation and interpreting – with a focus on training of future professionals, on language processing more generally, on the role of technology in the practice of translation and interpreting, on translation of multimodal media texts, on aspects of ergonomics and usability, on emotions, self-concept and psychological factors, and finally also on revision and post-editing. For the present publication, we selected a number of contributions presented at the Second International Congress on Translation, Interpreting and Cognition hosted by the Tra&Co Lab at the Johannes Gutenberg University of Mainz