Stellar masses and disk properties of Lupus young stellar objects traced by velocity-aligned stacked ALMA 13CO and C18O spectra

In recent ALMA surveys, the gas distributions and velocity structures of most of the protoplanetary disks can still not be imaged at high S/N due to the short integration time. In this work, we re-analyzed the ALMA 13CO (3-2) and C18O (3-2) data of 88 young stellar objects in Lupus with the velocity-aligned stacking method to enhance S/N and to study the kinematics and disk properties traced by molecular lines. This method aligns spectra at different positions in a disk based on the projected Keplerian velocities at their positions and then stacks them. This method enhances the S/N ratios of molecular-line data and allows us to obtain better detections and to constrain dynamical stellar masses and disk orientations. We obtain 13CO detections in 41 disks and C18O detections in 18 disks with 11 new detections in 13CO and 9 new detections in C18O after applying the method. We estimate the disk orientations and the dynamical stellar masses from the 13CO data. Our estimated dynamical stellar masses correlate with the spectroscopic stellar masses, and in a subsample of 16 sources, where the inclination angles are better constrained, the two masses are in a good agreement within the uncertainties and with a mean difference of 0.15 Msun. With more detections of fainter disks, our results show that high gas masses derived from the 13CO and C18O lines tend to be associated with high dust masses estimated from the continuum emission. Nevertheless, the scatter is large (0.9 dex), implying large uncertainties in deriving the disk gas mass from the line fluxes. We find that with such large uncertainties it is expected that there is no correlation between the disk gas mass and the mass accretion rate with the current data. Deeper observations to detect disks with gas masses <1E-5 Msun in molecular lines are needed to investigate the correlation between the disk gas mass and the mass accretion rate.Comment: Submitted to A&

Long-term follow-up of Philadelphia chromosome-positive (Ph+) chronic myeloid leukaemia (CML) in children and adolescents managed at a single institution over a 20-year period

Chronic myeloid leukaemia (CML) is rare in childhood. In our Institution we managed 30 consecutive Ph+CML patients aged <18 years, according to our adults’ guidelines. Patients with HLA-identical related donor (RD) underwent stem cell transplant (SCT). Since 1989, patients without RD were systematically treated with -interferon (IFN) (median dosage: 6 MU/day). Of 18/19 evaluable patients, 17 (94.5%) achieved haematologic response (HR), 11/17 (65%) cytogenetic response (CyR), complete (CCyR) in 4 (23.5%). Three patients remain in CCyR, 2 achieved BCR-ABL transcript disappearance. Of 13 patients without CCyR, 5 underwent SCT, 4 switched to STI571, 4 progressed. All patients receiving STI571 in chronic phase (CP) obtained sustained CCyR and 3 a persistent molecular response. 8-year survival among IFN-treated patients, censored or not for subsequent therapies, is 62% and 63%. Overall, 13/30 patients underwent SCT: 5 HLA-identical-RD, 5 matched unrelated donor, 2 mismatched-RD, 1 unrelated mismatched umbilical cord blood. Eight allotransplanted patients (6/6 in 1st CP) are in cytogenetic and molecular remission with 8-year survival of 61% from SCT and 69% from diagnosis. In our 20-year experience, the use of IFN in children without matched RD led to prolonged cytogenetic and molecular responses and long-term survival, without impairing the outcome of subsequent SCT

An ALMA Survey of Protoplanetary Disks in the σ\sigma Orionis Cluster

The $\sigma$ Orionis cluster is important for studying protoplanetary disk evolution, as its intermediate age ($\sim$3-5 Myr) is comparable to the median disk lifetime. We use ALMA to conduct a high-sensitivity survey of dust and gas in 92 protoplanetary disks around $\sigma$ Orionis members with $M_{\ast}\gtrsim0.1 M_{\odot}$. Our observations cover the 1.33 mm continuum and several CO $J=2-1$ lines: out of 92 sources, we detect 37 in the mm continuum and six in $^{12}$CO, three in $^{13}$CO, and none in C$^{18}$O. Using the continuum emission to estimate dust mass, we find only 11 disks with $M_{\rm dust}\gtrsim10 M_{\oplus}$, indicating that after only a few Myr of evolution most disks lack sufficient dust to form giant planet cores. Stacking the individually undetected continuum sources limits their average dust mass to 5$\times$ lower than that of the faintest detected disk, supporting theoretical models that indicate rapid dissipation once disk clearing begins. Comparing the protoplanetary disk population in $\sigma$ Orionis to those of other star-forming regions supports the steady decline in average dust mass and the steepening of the $M_{\rm dust}$-$M_{\ast}$ relation with age; studying these evolutionary trends can inform the relative importance of different disk processes during key eras of planet formation. External photoevaporation from the central O9 star is influencing disk evolution throughout the region: dust masses clearly decline with decreasing separation from the photoionizing source, and the handful of CO detections exist at projected separations $>1.5$ pc. Collectively, our findings indicate that giant planet formation is inherently rare and/or well underway by a few Myr of age.Comment: 16 pages, 9 figures; published in AJ; The full machine readable tables can be obtained by downloading and extracting the gzipped tar source file listed under "Other formats.

Subcellular localization of the five members of the human steroid 5α-reductase family

In humans the steroid 5a-reductase (SRD5A) family comprises five integral membrane enzymes that carry out reduction of a double bond in lipidic substrates: D4-3-keto steroids, polyprenol and trans-enoyl CoA. The best-characterized reaction is the conversion of testosterone into the more potent dihydrotestosterone carried out by SRD5A1-2. Some controversy exists on their possible nuclear or endoplasmic reticulum localization. We report the cloning and transient expression in HeLa cells of the five members of the human steroid 5a-reductase family as both N- and Cterminus green fluorescent protein tagged protein constructs. Following the intrinsic fluorescence of the tag, we have determined that the subcellular localization of these enzymes is in the endoplasmic reticulum, upon expression in HeLa cells. The presence of the tag at either end of the polypeptide chain can affect protein expression and, in the case of trans enoyl-CoA reductase, it induces the formation of protein aggregates

New insights into the nature of transition disks from a complete disk survey of the Lupus star forming region

Transition disks with large dust cavities around young stars are promising targets for studying planet formation. Previous studies have revealed the presence of gas cavities inside the dust cavities hinting at recently formed, giant planets. However, many of these studies are biased towards the brightest disks in the nearby star forming regions, and it is not possible to derive reliable statistics that can be compared with exoplanet populations. We present the analysis of 11 transition disks with large cavities (>20 AU radius) from a complete disk survey of the Lupus star forming region, using ALMA Band 7 observations at 0.3" (22-30 AU radius) resolution of the 345 GHz continuum, 13CO and C18O 3-2 observations and the Spectral Energy Distribution of each source. Gas and dust surface density profiles are derived using the physical-chemical modeling code DALI. This is the first study of transition disks of large cavities within a complete disk survey within a star forming region. The dust cavity sizes range from 20-90 AU radius and in three cases, a gas cavity is resolved as well. The deep drops in gas density and large dust cavity sizes are consistent with clearing by giant planets. The fraction of transition disks with large cavities in Lupus is ~11%, which is inconsistent with exoplanet population studies of giant planets at wide orbits. Furthermore, we present a hypothesis of an evolutionary path for large massive disks evolving into transition disks with large cavities.Comment: 29 pages, 15 figures, Accepted by Ap

Global variation of the dust-to-gas ratio in evolving protoplanetary discs

Recent theories suggest planetesimal formation via streaming and/or gravitational instabilities may be triggered by localized enhancements in the dust-to-gas ratio, and one hypothesis is that sufficient enhancements may be produced in the pile-up of small solid particles inspiralling under aerodynamic drag from the large mass reservoir in the outer disc. Studies of particle pile-up in static gas discs have provided partial support for this hypothesis. Here, we study the radial and temporal evolution of the dust-to-gas ratio in turbulent discs, that evolve under the action of viscosity and photoevaporation. We find that particle pile-ups do not generically occur within evolving discs, particularly if the introduction of large grains is restricted to the inner, dense regions of a disc. Instead, radial drift results in depletion of solids from the outer disc, while the inner disc maintains a dust-to-gas ratio that is within a factor of ~2 of the initial value. We attribute this result to the short time-scales for turbulent diffusion and radial advection (with the mean gas flow) in the inner disc. We show that the qualitative evolution of the dust-to-gas ratio depends only weakly upon the parameters of the disc model (the disc mass, size, viscosity, and value of the Schmidt number), and discuss the implications for planetesimal formation via collective instabilities. Our results suggest that in discs where there is a significant level of midplane turbulence and accretion, planetesimal formation would need to be possible in the absence of large-scale enhancements. Instead, trapping and concentration of particles within local turbulent structures may be required as a first stage of planetesimal formation.Comment: Accepted by Monthly Notices of the Royal Astronomical Society on the 8th of March 2012. 20 pages. 16 figure

PEDIATRIC HODGKIN LYMPHOMA IN LOW- and MIDDLE-INCOME COUNTRIES (LMICs). A NARRATIVE REVIEW

Pediatric Hodgkin lymphoma (HL) is a curable disease for more than 90% of children and adolescents in high income countries. However, similar results cannot be achieved, particularly for advanced disease, in low- and middle-income countries (LMICs), where challenging socioeconomic realities and the consequent scarcity of local resources heavily impact on the treatment and patients’ outcome. Information regarding the management and outcome of pediatric HL in LMICs is still limited. In this narrative review, we summarize the results reported in the literature so far and discuss the critical key points that have emerged from this overview

Metabolomics as a Powerful Tool for Molecular Quality Assessment of the Fish Sparus aurata

The molecular profiles of perchloric acid solutions extracted from the flesh of Sparus aurata fish specimens, produced according to different aquaculture systems, have been investigated. The 1H-NMR spectra of aqueous extracts are indicative of differences in the metabolite content of fish reared under different conditions that are already distinguishable at their capture, and substantially maintain the same differences in their molecular profiles after sixteen days of storage under ice. The fish metabolic profiles are studied by top-down chemometric analysis. The results of this exploratory investigation show that the fish metabolome accurately reflects the rearing conditions. The level of many metabolites co-vary with the rearing conditions and a few metabolites are quantified including glycogen (stress indicator), histidine, alanine and glycine which all display significant changes dependent on the aquaculture system and on the storage times