Effect of a pedometer-based walking intervention on body composition in patients with ESRD: a randomized controlled trial.

BackgroundA randomized trial of a pedometer-based intervention with weekly activity goals led to a modest increase in step count among dialysis patients. In a secondary analysis, we investigated the effect of this intervention on body composition.MethodsSixty dialysis patients were randomized to standard care or a 6-month program consisting of 3 months of pedometers and weekly step count targets and 3 months of post-intervention follow-up. We obtained bioelectrical impedance spectroscopy (BIS) data on 54 of these patients (28 control, 26 intervention) and used linear mixed-modeling (adjusted for sex and dialysis modality) to estimate differences in change in total-body muscle mass (TBMM) adjusted for height2, fat mass (kg), and body mass index (BMI) (kg/m2) between control and intervention groups.ResultsThe median age of participants was 57.5 years (53-66), and 76% were men. At baseline, there was no significant difference between groups in age, BMI, race, or body composition, but there were more men in the intervention group. After 3 months, patients in the intervention group increased their average daily steps by 2414 (95% CI 1047, 3782) more than controls (p < 0.001), but there were no significant differences in body composition. However, at 6 months, participants in the intervention had a significantly greater increase from baseline in TBMM of 0.7 kg/m2 (95% CI 0.3, 1.13), decrease in fat mass (- 4.3 kg [95% CI -7.1, - 1.5]) and decrease in BMI (- 1.0 kg/m2 [95% CI -1.8, - 0.2]) relative to controls. In post-hoc analysis, each increase of 1000 steps from 0 to 3 months was associated with a 0.3 kg decrease in fat mass (95% CI 0.05, 0.5) from 0 to 6 months, but there was no dose-response relationship with TBMM/ht2 or BMI.ConclusionA pedometer-based intervention resulted in greater decreases in fat mass with relative preservation of muscle mass, leading to a greater decrease in BMI over time compared with patients not in the intervention. These differences were driven as much by worsening in the control group as by improvement in the intervention group. Step counts had a dose-response relationship with decrease in fat mass.Trial registrationClinicalTrials.gov (NCT02623348). 02 December 2015

Assessment of bycatch and discards associated with bottom trawling along Karnataka coast, India

The quantity of bycatch and discard was estimated from the landings of multiday fishing trawlers (MDF) at fisheries harbours and using the data collected onboard single-day fishing trawlers (SDF) for the period 2001-02. The quantity of bycatch generated by trawling along Kamataka coast was estimated as 56,035 tin 2001 and 52,380 t in 2002 forming 54 % and 48 % of total trawl catch respectively

Record of the rough toothed dolphin Steno bredanensis (G. Cuvier in Lesson, 1828) in Indian seas after 19th century

A specimen of the rare delphinid Steno bredanensis, was washed ashore on 25 August 2008 in Uttara Kannada, south-west coast of India. This report presents the first stranding record of S. bredanensis in Indian waters after more than 100 years as the previous confirmed record was only in 1891. There were a few stranding records of this species in 19th century, but thereafter no single record is available till now. The number of records between the years 1800 and 1900 were only 3. Earlier works from Indian seas depended on conventional taxonomic approaches which led to misidentification of species. Skin samples were collected for genetic analysis and the genes of control region (CR) and cytochrome b (cyt b) of MtDNA were PCR amplified and sequenced. Partial sequences of mtDNA control region and cytochrome b genes were generated and tested with the reference sequences available in GenBank (NCBI) and the web-based program DNA Surveillance, and the specimen was confirmed as Steno bredanensis. Amplification of sex Y chromosome gene SRY confirmed the visual identification of the specimen as a male

Conservation and divergence of ADAM family proteins in the Xenopus genome

Background Members of the disintegrin metalloproteinase (ADAM) family play important roles in cellular and developmental processes through their functions as proteases and/or binding partners for other proteins. The amphibian Xenopus has long been used as a model for early vertebrate development, but genome-wide analyses for large gene families were not possible until the recent completion of the X. tropicalis genome sequence and the availability of large scale expression sequence tag (EST) databases. In this study we carried out a systematic analysis of the X. tropicalis genome and uncovered several interesting features of ADAM genes in this species. Results Based on the X. tropicalis genome sequence and EST databases, we identified Xenopus orthologues of mammalian ADAMs and obtained full-length cDNA clones for these genes. The deduced protein sequences, synteny and exon-intron boundaries are conserved between most human and X. tropicalis orthologues. The alternative splicing patterns of certain Xenopus ADAM genes, such as adams 22 and 28, are similar to those of their mammalian orthologues. However, we were unable to identify an orthologue for ADAM7 or 8. The Xenopus orthologue of ADAM15, an active metalloproteinase in mammals, does not contain the conserved zinc-binding motif and is hence considered proteolytically inactive. We also found evidence for gain of ADAM genes in Xenopus as compared to other species. There is a homologue of ADAM10 in Xenopus that is missing in most mammals. Furthermore, a single scaffold of X. tropicalis genome contains four genes encoding ADAM28 homologues, suggesting genome duplication in this region. Conclusions Our genome-wide analysis of ADAM genes in X. tropicalis revealed both conservation and evolutionary divergence of these genes in this amphibian species. On the one hand, all ADAMs implicated in normal development and health in other species are conserved in X. tropicalis. On the other hand, some ADAM genes and ADAM protease activities are absent, while other novel ADAM proteins in this species are predicted by this study. The conservation and unique divergence of ADAM genes in Xenopus probably reflect the particular selective pressures these amphibian species faced during evolution.National Institutes of Health. Department of Health and Human Services (Ruth L. Kirschstein postdoctoral fellowship)National Institutes of Health. Department of Health and Human Services (5T32GA09109)American Heart Association (postdoctoral fellowship)March of Dimes Birth Defects Foundation (grant 1-FY10-399)March of Dimes Birth Defects Foundation (grant F405-140)National Institutes of Health (U.S.) (HD26402)National Institutes of Health (U.S.) (DE14365

Giant Dipole Resonance studies in Ba isotopes at E/A∼\textbf{ E/A}\sim 5 MeV

Exclusive measurements of high energy $\gamma$-rays are performed in $\rm ^{124}Ba$ and $\rm ^{136}Ba$ at the same excitation energy ($\sim$ 49 MeV), to study properties of the giant dipole resonance (GDR) over a wider $N/Z$ range. The high energy $\gamma$-rays are measured in coincidence with the multiplicity of low energy $\gamma$-rays to disentangle the effect of temperature ($T$) and angular momentum ($J$). The GDR parameters are extracted employing a simulated Monte Carlo statistical model analysis. The observed $\gamma$-ray spectra of $\rm ^{124}Ba$ can be explained with prolate deformation, whereas a single component Lorentzian function which corresponds to a spherical shape could explain the $\gamma$-ray spectra from $\rm ^{136}Ba$. The observed GDR width in $\rm ^{136}Ba$ is narrower compared to that of $\rm ^{124}Ba$. The statistical model best fit GDR cross sections are found to be in good agreement with the thermal shape fluctuation model (TSFM) calculations. Further, it is shown that the variation of GDR width with $T$ is well reproduced by the TSFM calculations over the temperature range of 1.1--1.7MeV.Comment: 16 pages, 7 figure

Characterization of PARIS LaBr3_3(Ce)-NaI(Tl) phoswich detectors upto EγE_\gamma ∼\sim 22 MeV

In order to understand the performance of the PARIS (Photon Array for the studies with Radioactive Ion and Stable beams) detector, detailed characterization of two individual phoswich (LaBr$_3$(Ce)-NaI(Tl)) elements has been carried out. The detector response is investigated over a wide range of $E_{\gamma}$ = 0.6 to 22.6 MeV using radioactive sources and employing $^{11}B(p,\gamma)$ reaction at $E_p$ = 163 keV and $E_p$ = 7.2 MeV. The linearity of energy response of the LaBr$_3$(Ce) detector is tested upto 22.6 MeV using three different voltage dividers. The data acquisition system using CAEN digitizers is set up and optimized to get the best energy and time resolution. The energy resolution of $\sim$ 2.1% at $E_\gamma$ = 22.6~MeV is measured for the configuration giving best linearity upto high energy. Time resolution of the phoswich detector is measured with a $^{60}$Co source after implementing CFD algorithm for the digitized pulses and is found to be excellent (FWHM $\sim$ 315~ps). In order to study the effect of count rate on detectors, the centroid position and width of the $E_{\gamma}$ = 835~keV peak were measured upto 220 kHz count rate. The measured efficiency data with radioactive sources are in good agreement with GEANT4 based simulations. The total energy spectrum after the add-back of energy signals in phoswich components is also presented.Comment: Accepted in JINS

Iodine oxide in the global marine boundary layer

Prados-Roman, C. ... et. al.-- 11 pages, 7 figures, 2 tables, The Supplement related to this article is available online at https://doi.org/10.5194/acp-15-583-2015-supplementEmitted mainly by the oceans, iodine is a halogen compound important for atmospheric chemistry due to its high ozone depletion potential and effect on the oxidizing capacity of the atmosphere. Here we present a comprehensive data set of iodine oxide (IO) measurements in the open marine boundary layer (MBL) made during the Malaspina 2010 circumnavigation. Results show IO mixing ratios ranging from 0.4 to 1 pmol mol-1 (30% uncertainty) and, complemented with additional field campaigns, this data set confirms through observations the ubiquitous presence of reactive iodine chemistry in the global marine environment. We use a global model with organic (CH3I, CH2ICl, CH2I2 and CH2IBr) and inorganic (HOI and I2) iodine ocean emissions to investigate the contribution of the different iodine source gases to the budget of IO in the global MBL. In agreement with previous estimates, our results indicate that, globally averaged, the abiotic precursors contribute about 75 % to the IO budget. However, this work reveals a strong geographical pattern in the contribution of organic vs. inorganic precursors to reactive iodine in the global MBL. © Author(s) 2015The Indian Institute of Tropical Meteorology is supported by the Ministry of Earth Sciences, Government of India. R. P. Fernandez would like to thank ANPCyT (PICT-PRH 2009-0063) for financial supportPeer Reviewe

Coronary CT Angiography and 5-Year Risk of Myocardial Infarction.

BACKGROUND: Although coronary computed tomographic angiography (CTA) improves diagnostic certainty in the assessment of patients with stable chest pain, its effect on 5-year clinical outcomes is unknown. METHODS: In an open-label, multicenter, parallel-group trial, we randomly assigned 4146 patients with stable chest pain who had been referred to a cardiology clinic for evaluation to standard care plus CTA (2073 patients) or to standard care alone (2073 patients). Investigations, treatments, and clinical outcomes were assessed over 3 to 7 years of follow-up. The primary end point was death from coronary heart disease or nonfatal myocardial infarction at 5 years. RESULTS: The median duration of follow-up was 4.8 years, which yielded 20,254 patient-years of follow-up. The 5-year rate of the primary end point was lower in the CTA group than in the standard-care group (2.3% [48 patients] vs. 3.9% [81 patients]; hazard ratio, 0.59; 95% confidence interval [CI], 0.41 to 0.84; P=0.004). Although the rates of invasive coronary angiography and coronary revascularization were higher in the CTA group than in the standard-care group in the first few months of follow-up, overall rates were similar at 5 years: invasive coronary angiography was performed in 491 patients in the CTA group and in 502 patients in the standard-care group (hazard ratio, 1.00; 95% CI, 0.88 to 1.13), and coronary revascularization was performed in 279 patients in the CTA group and in 267 in the standard-care group (hazard ratio, 1.07; 95% CI, 0.91 to 1.27). However, more preventive therapies were initiated in patients in the CTA group (odds ratio, 1.40; 95% CI, 1.19 to 1.65), as were more antianginal therapies (odds ratio, 1.27; 95% CI, 1.05 to 1.54). There were no significant between-group differences in the rates of cardiovascular or noncardiovascular deaths or deaths from any cause. CONCLUSIONS: In this trial, the use of CTA in addition to standard care in patients with stable chest pain resulted in a significantly lower rate of death from coronary heart disease or nonfatal myocardial infarction at 5 years than standard care alone, without resulting in a significantly higher rate of coronary angiography or coronary revascularization. (Funded by the Scottish Government Chief Scientist Office and others; SCOT-HEART ClinicalTrials.gov number, NCT01149590 .)

Increase Productivity Through Knowledge Management

Increase in competition level requires companies to improve the efficiency of work force use characterized by labor productivity. Professional knowledge of staff and its experience play the key role in it. The results of Extrusion Line operator's working time analysis are performed in this article. The analysis revealed that the reasons of working time ineffective use connected with inadequate information exchange and knowledge management in the company. Authors suggest the way to solve this problem: the main sources of knowledge in engineering enterprise have been defined, the conditions of success and the stages of knowledge management control have been stated