99 research outputs found
An exploration into urban agriculture and rooftop gardens in Johannesburg
A research report submitted to the School of Architecture and Planning
In Partial Fulfilment of the Requirements for the Degree:
Master of Architecture in Sustainable and Energy Efficient Cities (MArch SEEC)
University of the Witwatersrand
October 2017.This study arises from the insight that the critical role of green infrastructure in urban areas is often not focussed upon at the same level and intensity as “standard” infrastructure such as roads, water and electricity. The key research question guiding the study revolves around whether urban agriculture should be included in the design process of buildings in Johannesburg, and how this could subsequently address the inter-relationships between city and building scale, aesthetics versus biodiversity as well as addressing the critical challenge of water scarcity through the process of greening the city. With this in mind, this study argues for a potential shift in land use control, whereby urban agriculture could be strictly regulated as a specific land use typology similar to the commonly recognised uses such as industrial, commercial or residential.
An overall qualitative approach was undertaken using the theoretical underpinnings envisaged by Lehmann (2010) and the 15 principles of Green Urbanism, to gain an understanding of the role players and processes involved in the building cycle, as well as urban agriculture development. Key role players were identified, and interviewed, substantiating how policy insight is necessary in practice.
The focus of this research report was on the building, and specifically the potential that buildings may offer a contribution towards green infrastructure, by providing such outcomes as passive thermal control and food security. Key comparisons were made between cities that go beyond the implementation of urban agriculture as an “extracurricular” activity, and fully embrace the holistic view of green urban development and sustainable cities. Examples have been taken from London, Toronto and Singapore regarding how rooftop gardens and urban agriculture have been included into the urban fabric. Johannesburg has a few initiatives, which are greatly reduced in scale when compared to these other cities, however, the local context needs to be considered when investigating the reason for this. Considering the importance of the benefits of such programmes (such as food security and job creation), it can be concluded that this inclusion of urban agriculture in the planning phase should be prioritised as an important intervention for urban development.MT 201
Extensive population genetic structure in the giraffe
<p>Abstract</p> <p>Background</p> <p>A central question in the evolutionary diversification of large, widespread, mobile mammals is how substantial differentiation can arise, particularly in the absence of topographic or habitat barriers to dispersal. All extant giraffes (<it>Giraffa camelopardalis</it>) are currently considered to represent a single species classified into multiple subspecies. However, geographic variation in traits such as pelage pattern is clearly evident across the range in sub-Saharan Africa and abrupt transition zones between different pelage types are typically not associated with extrinsic barriers to gene flow, suggesting reproductive isolation.</p> <p>Results</p> <p>By analyzing mitochondrial DNA sequences and nuclear microsatellite loci, we show that there are at least six genealogically distinct lineages of giraffe in Africa, with little evidence of interbreeding between them. Some of these lineages appear to be maintained in the absence of contemporary barriers to gene flow, possibly by differences in reproductive timing or pelage-based assortative mating, suggesting that populations usually recognized as subspecies have a long history of reproductive isolation. Further, five of the six putative lineages also contain genetically discrete populations, yielding at least 11 genetically distinct populations.</p> <p>Conclusion</p> <p>Such extreme genetic subdivision within a large vertebrate with high dispersal capabilities is unprecedented and exceeds that of any other large African mammal. Our results have significant implications for giraffe conservation, and imply separate <it>in situ </it>and <it>ex situ </it>management, not only of pelage morphs, but also of local populations.</p
The role of anti-malarial drugs in eliminating malaria
Abstract Effective anti-malarial drug treatment reduces malaria transmission. This alone can reduce the incidence and prevalence of malaria, although the effects are greater in areas of low transmission where a greater proportion of the infectious reservoir is symptomatic and receives anti-malarial treatment. Effective treatment has greater effects on the transmission of falciparum malaria, where gametocytogenesis is delayed, compared with the other human malarias in which peak gametocytaemia and transmissibility coincides with peak asexual parasite densities. Mature Plasmodium falciparum gametocytes are more drug resistant and affected only by artemisinins and 8-aminoquinolines. The key operational question now is whether primaquine should be added to artemisinin combination treatments for the treatment of falciparum malaria to reduce further the transmissibility of the treated infection. Radical treatment with primaquine plays a key role in the eradication of vivax and ovale malaria. More evidence is needed on the safety of primaquine when administered without screening for G6PD deficiency to inform individual and mass treatment approaches in the context of malaria elimination programmes.</p
Efficacy of depatuxizumab mafodotin (ABT-414) monotherapy in patients with EGFR-amplified, recurrent glioblastoma: results from a multi-center, international study
Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial.
BACKGROUND: Remote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). We investigated whether remote ischaemic conditioning could reduce the incidence of cardiac death and hospitalisation for heart failure at 12 months. METHODS: We did an international investigator-initiated, prospective, single-blind, randomised controlled trial (CONDI-2/ERIC-PPCI) at 33 centres across the UK, Denmark, Spain, and Serbia. Patients (age >18 years) with suspected STEMI and who were eligible for PPCI were randomly allocated (1:1, stratified by centre with a permuted block method) to receive standard treatment (including a sham simulated remote ischaemic conditioning intervention at UK sites only) or remote ischaemic conditioning treatment (intermittent ischaemia and reperfusion applied to the arm through four cycles of 5-min inflation and 5-min deflation of an automated cuff device) before PPCI. Investigators responsible for data collection and outcome assessment were masked to treatment allocation. The primary combined endpoint was cardiac death or hospitalisation for heart failure at 12 months in the intention-to-treat population. This trial is registered with ClinicalTrials.gov (NCT02342522) and is completed. FINDINGS: Between Nov 6, 2013, and March 31, 2018, 5401 patients were randomly allocated to either the control group (n=2701) or the remote ischaemic conditioning group (n=2700). After exclusion of patients upon hospital arrival or loss to follow-up, 2569 patients in the control group and 2546 in the intervention group were included in the intention-to-treat analysis. At 12 months post-PPCI, the Kaplan-Meier-estimated frequencies of cardiac death or hospitalisation for heart failure (the primary endpoint) were 220 (8·6%) patients in the control group and 239 (9·4%) in the remote ischaemic conditioning group (hazard ratio 1·10 [95% CI 0·91-1·32], p=0·32 for intervention versus control). No important unexpected adverse events or side effects of remote ischaemic conditioning were observed. INTERPRETATION: Remote ischaemic conditioning does not improve clinical outcomes (cardiac death or hospitalisation for heart failure) at 12 months in patients with STEMI undergoing PPCI. FUNDING: British Heart Foundation, University College London Hospitals/University College London Biomedical Research Centre, Danish Innovation Foundation, Novo Nordisk Foundation, TrygFonden
On (Not) Obeying the Sabbath: Reading Jesus Reading Scripture
Permission from the editor to release the post-refereed, pre-print version of this work is pending. Please contact the ICS library if you would like to request this work
ICT37XXHS L0101 / ICT67XXHS L0101. Birthpangs of the New Creation: Judgment Unto Salvation in the Book of Revelation
In our culture, “apocalypse” typically refers to a cataclysmic, catastrophic ending, real or imagined. Often this meaning, in which fear eclipses hope, is traced back to the biblical tradition. But what if the book from which we derive the term, i.e. the “Apocalypse”—or “Revelation”—of John, refers less to the end of the world than to a transition between the two Ages? What if that transition is characterized as double-edged: as both ‘the death throes of the old world order’ and ‘the birthpangs of the new creation’? Attentive to the nature of apocalyptic discourse, this course will seek to develop a key area of systematic theology by exploring the topics of death, judgment, heaven, and hell—the ‘four last things’ of traditional eschatology—as they are portrayed in the book of Revelation. In allowing intertexual and intratextual webs of meaning to emerge, we will pay special attention to the way in which Old Testament echoes, together with the book’s own symbolic coherence and narrative logic, can open up new avenues for exegesis, and for theological reflection. The topic of Final Judgment will be a special focus. How is this to be conceived in the light of the apocalyptic transition? If the first reference to Babylon in the biblical canon, the Babel narrative of Gen 11, refers to a judgment that does not bring history to an end but opens it up once again to the dissemination motif of Gen 1:28, is it possible to detect a parallel ‘judgment unto salvation’ theme in the final book of the New Testament? Our discussions will explore the interface between biblical studies, the “theological interpretation of Scripture,” and contemporary eschatology. Familiarity with New Testament Greek is an advantage but is not a prerequisite
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