Pelaksanaan Pertanggungjawaban Sosial Perbankan terhadap Koperasi dalam Hal Sertifikasi Kekayaan Intelektual Sebagai Jaminan Kredit Perbankan

HKI is a work declared by creative economic actors as an effort to encourage Indonesia's economic growth. In addition to being a form of legal protection, the existence of one type of HKI namely the brand can be used as a concept as collateral. In fact, there is no legal force to implement this because there are no regulations governing it, causing legal uncertainty for the parties involved, especially regarding the policy of banking institutions in providing credit to cooperatives or UMKM that have been certified. The results of this paper show that the application of collective brand certificates to be used as collateral for bank loans does not yet have legal certainty, and the efforts that can be made by the government are to harmonize regulations, provide counseling on the importance of the existence of HKI, and monitor the balance between applicable rules and reality. which took place in the field. The role of cooperatives or UMKM is to maintain good performance when banking institutions have provided access to capital in the form of credit by implementing the Linkage Program Executing pattern based on the principle of consensus or trust and applying risk management principles in each credit agreement. The social responsibility of banking institutions in this case is to provide easing of collateral and is not commercial in nature

Tackling fraud and corruption in Indonesia’s health insurance system

Proper assessment, management, and mitigation of fraud and corruption risks is crucial for safeguarding Indonesia’s National Health Insurance programme

Pelaksanaan Pertanggungjawaban Sosial Perbankan terhadap Koperasi dalam Hal Sertifikasi Kekayaan Intelektual Sebagai Jaminan Kredit Perbankan

HKI is a work declared by creative economic actors as an effort to encourage Indonesia's economic growth. In addition to being a form of legal protection, the existence of one type of HKI namely the brand can be used as a concept as collateral. In fact, there is no legal force to implement this because there are no regulations governing it, causing legal uncertainty for the parties involved, especially regarding the policy of banking institutions in providing credit to cooperatives or UMKM that have been certified. The results of this paper show that the application of collective brand certificates to be used as collateral for bank loans does not yet have legal certainty, and the efforts that can be made by the government are to harmonize regulations, provide counseling on the importance of the existence of HKI, and monitor the balance between applicable rules and reality. which took place in the field. The role of cooperatives or UMKM is to maintain good performance when banking institutions have provided access to capital in the form of credit by implementing the Linkage Program Executing pattern based on the principle of consensus or trust and applying risk management principles in each credit agreement. The social responsibility of banking institutions in this case is to provide easing of collateral and is not commercial in nature.</jats:p

Business Email Compromise (BEC) Fraud and How to Prevent it

Cybercrime is on the rise both at the national and cross-border levels. The latest mode of cybercrime is fraud using Business Email Compromise (BEC). A qualitive analysis method with literature study is applied to discuss two key questions of this paper. First, how does the BEC scheme occur?. Second, how an organization/company can prevent/mitigate the risk of BEC fraud. This paper concludes that BEC can be executed in the form of phishing emails sent by perpetrators (both internal and external actors of the organization) to the target victim (organization’s employees) in order to deceive and obtain financial gain. Various efforts can be made by an organization/company to prevent the risk of BEC fraud, among others in the form of implementing a risk management system, implementing an information security management system, and increasing the organization’s internal awareness

Human Myeloma Cells Undergo Differentiation and Apoptosis upon Exposure of Rosiglitazone and All-Trans Retinoic Acid Via Apoptosis Signaling Pathway Modulation

Abstract Background Myeloma cells often develop drug resistance leading to treatment failure in the patients. New agents that can overcome drug resistance through induction of apoptosis and differentiation are needed. PPARg serves as a transcription factor and functions as a heterodimer with Retinoid X receptor a (RXRa). Activation of PPARg by its ligands has shown potential anti-neoplastic effects in solid tumors. In this study, we investigate the effects of RGZ as well as combined with all trans-retinoic acid (ATRA) on human myeloma cell lines and try to address its potential mechanism. Method U266 and RPMI-8226 cells were treated with different concentration of RGZ in the presence or absence of ATRA and various biological responses were studied by the methods of [3H] thymidine incorporation, MTT, cell cycle analysis, Annexin V-PI stanning, Wright-Gemsa staining, RT-PCR and caspase-3 activity assay. Results We report that exposure to RGZ induced proliferation inhibition and viability loss in a dose-dependent manner in both U266 and RPMI-8226 cells. A similar exposure to RGZ also induced cell cycle arrest, cell differentiation and apoptosis of myeloma cells. A combination of RGZ with ATRA enhanced the effects of RGZ and induced cell differentiation in myeloma cells. The mRNA expressions of FLIP, XIAP and survivin were detected in both cell lines and the levels decreased significantly after cultured with RGZ, similar synergism effect of ATRA and RGZ on mRNA level of these apoptosis related genes was also observed. Caspase-3 activity increased substantially along with the increase of RGZ concentration and the addition of ATRA in culture medium shows similar synergism effect on caspase-3 activation. Conclusion These results suggested that RGZ may represent a promising candidate for the treatment of multiple myeloma and ATRA may be useful as a combination therapy for multiple myeloma.</jats:p

Primary treatment of leukemia relapses after allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning second transplantation from the original donor

Acute leukemia relapsing after allogeneic hematopoietic stem cell transplantation (HSCT) has dismal outcome. Consecutive consenting patients (acute myeloid leukemia: N=71; acute lymphoblastic leukemia: N=37), at a median age of 37 (16-57) years, who had relapsed 7.9 (1.3-132) months post-HSCT, were treated with three cytarabine-based intensive regimens as reduced-intensity conditioning (RIC), followed by infusion of mobilized HSC from the original donors. There were four treatment-related mortalities (TRMs). Of 104 evaluable cases, 72 patients (67%) achieved complete remission (CR)/CR with incomplete hematologic recovery (CRi). The median overall survival (OS) of the entire cohort was 11.6 months. The OS of patients achieving CR/CRi after the first RIC/HSCT was 18.8 months, as compared with 3.9 months for those not (P<0.01). For 32 patients with nonremission, 11 received a repeat RIC-HSCT, leading to CR/CRi in three cases. Therefore, 75/108 (69%) of patients achieved CR/CRi after one or two courses of RIC-HSCT. Among CR/CRi patients, 48 cases relapsed again after 6.1 (1.0-64.4) months. Thirty cases received a repeat RIC-HSCT, leading to CR/CRi in 22 patients. Multivariate analyses showed a significant impact of remission duration after initial HSCT (P=0.026) and the presence of acute graft-versus-host disease after RIC-HSCT (P=0.011) on CR/CRi. RIC-HSCT as primary treatment for acute leukemic relapses post-HSCT induced a high CR rate with low TRM. Optimal postremission treatment remains to be defined. © 2013 Wiley Periodicals, Inc.link_to_subscribed_fulltex

Antifungal drug usage in haematologic patients during a 4-year period in an Asian university teaching hospital

Background: Invasive fungal disease (IFD) is an important problem complicating the therapy of haematologic patients. Aim: This study aimed to provide data on the epidemiology of IFD in an Asian teaching hospital, as well as the prescription practice of antifungal drugs. Method: We conducted a retrospective review of 275 haematologic patients who were prescribed antifungal drugs in a 4-year period (2007-2010), of whom 130 (47%) had undergone haematopoietic stem cell transplantation. Results: Antifungal prophylaxis with either fluconazole or itraconazole was given in 214 patients (78%). There were 414 prescriptions of antifungal drugs (including liposomal amphotericin B, voriconazole, caspofungin, micafungin, anidulafungin), of which 361 prescriptions were empirical. There were 14 patients with proven IFD, 11 of whom had breakthrough infection while on itraconazole prophylaxis. Interestingly, seven of these cases were due to infection by itraconazole-sensitive candida. Conclusion: These results provide important epidemiologic data necessary for the formulation of strategies for prevention and treatment of IFD in Asian patients. © 2012 Royal Australasian College of Physicians.link_to_subscribed_fulltex