The effect of carbohydrate ingestion on the Interleukin-6 response to a 90-minute run time trial

Fatigue is a predictable outcome of prolonged physical activity; yet its biological cause remains uncertain. During exercise, a polypeptide messenger molecule interleukin- 6 (IL-6) is actively produced. Previously, it has been demonstrated that administration of recombinant IL-6 (rhIL-6) impairs 10-km run performance and heightened sensation of fatigue in trained runners. Both high carbohydrate diets and carbohydrate ingestion during prolonged exercise have a blunting effect on IL-6 levels postendurance exercise. We hypothesized that carbohydrate ingestion may improve performance during a prolonged bout of exercise as a consequence of a blunted IL-6 response. Seven recreationally trained fasted runners completed two 90-min time trials under CHO supplemented and placebo conditions in a randomized order. The study was of a double-blinded, placebo-controlled, cross-over study design. Distance covered in 90 min was significantly greater following exogenous carbohydrate ingestion compared with the placebo trial (19.13 ± 1.7 km and 18.29 ± 1.9 km, respectively, p = .0022). While postexercise IL-6 levels were significantly lower in the CHO trial compared with the placebo trial (5.3 ± 1.9 pg·mL?1and 6.6 ± 3.0 pg·mL?1, respectively; p = .0313), this difference was considered physiologically too small to mediate the improvement in time trial performance

“Software agents and haunted media : the twitter bot as political actor"

This report examines the rhetorical construction of Twitter bots as nonhuman political agents in press coverage of the 2016 U.S. election. It takes the rhetorical framing of “the Twitter bot” as a case study to argue that Twitter bots are a contemporary example of what media historian Jeffrey Sconce calls “haunted media” -- a communication technology that has been culturally ascribed an “uncanny” “agency.” First, this report provides a comparative close reading of two pieces from The Atlantic and The New York Times as examples of mainstream press coverage of bots shortly before and after the 2016 U.S. presidential election. Second, drawing on Sconce’s analysis of nineteenth and twentieth century media ecologies, it argues that “the Twitter bot” has been rhetorically constructed as haunted media through discourses that are inseparable from larger political narratives. The third and final section speculates on possible theoretical frameworks to expand this project in further inquiries. This report aims to demonstrate that haunted media narratives predate and persist beyond a specific election cycle or medium, and to argue that the construction of “haunted media” occurs alongside constructed concepts of democracy in our technologically mediated society. In doing so, this report contributes to the field of rhetoric of digital technology by bringing it further into conversation with political rhetoric.Englis

LRR Focus: We Need to Get Together More

[Excerpt] Luvernel Clark is shop steward of ACTWU Local 1742 in Knoxville, Tennessee and chairperson of the Tennessee Industrial Renewal Network\u27s Maquiladora Committee which participated in a worker exchange to Mexico in the summer of 1991. She works at Allied Signal, in a plant that had 3000 employees in 1971, but today has less than 400, The jobs were sent by Allied first to a non-union greenfield location in Greenville, Alabama in 1982, and from there to Agua Prieta, Mexico. Fran Ansley, associate professor at the University of Tennessee College of Law and member of the TIRN delegation, interviewed Clark for Labor Research Review

Human Spaceflight Recent Conjunctions of Interest

I. During each nine-hour shift (or upon request), the Orbital Safety Analyst (OSA) at JSpOC updates the entire tracked catalog with the latest tracking data from the SSN and screens this catalog against NASA s assets. a) For ISS operations, a 72-hour advance screening is performed. b) For Shuttle orbit operations, a 36-hour advance screening is performed. c) If a vehicle is performing a maneuver during the screening period, OSA uses post-reboost-trajectory data supplied by Mission Control Center-Houston (MCC-H) for screening. II. An automated process is used to detect any conjunctions within 10 x 40 x 40 km box (centered on the vehicle) using Special Perturbation (SP) processing: a) Box dimensions are Radial x Downtrack x Crosstrack. b) Any object found within this box has the tracking tasking level increased to improve (hopefully) its uncertainty in its current and predicted orbital trajectory. c) OSA informs NASA if any object is found inside a 2 x 25 x 25 km box then creates and sends an Orbital Conjunction Message (OCM) to NASA which contains detailed information about the conjunction. d) For Shuttle, the box size used for screening and reporting is altered for special operations (day of rendezvous, launch screening, etc.)

The effect of exercise on plasma soluble IL-6 receptor concentration: a dichotomous response

The aim of this article is to review current literature on the response of soluble interleukin-6 receptor to exercise and identify a potential role for sIL-6R in skeletal muscle function. We also provide novel data on the impact of eccentric exercise on circulating levels. The aim of the research study was to investigate changes in plasma concentration of soluble interleukin-6 receptor (sIL-6R) and soluble glycoprotein 130 (sgp130) during recovery from exercise-induced muscle damage (EIMD) up to 72 h and their relationship with delayed onset muscle soreness (DOMS) and muscle function. 18 participants attended the laboratory on 4 consecutive days. On the first day, participants completed 6 sets of 10 repetitions of unilateral eccentric-concentric knee flexions at a test speed of 1.05 rad.s(-1) using a Cybex Isokentic dynamometer to induce muscle damage of the hamstrings. Prior to the eccentric exercise bout and each subsequent morning, following an overnight fast, participants had a venous blood sample taken which was centrifuged immediately and plasma frozen at -80 degrees C until later analysis. Plasma IL-6 and sgp130 were unchanged at any time point during recovery but sIL-6R was significantly reduced at 48 h and 72 h post-exercise (p < 0.05). Plasma sIL-6R was correlated with DOMS at 48 h post EIMD (r = 0.45, p < 0.05) and peak muscle torque at 24 h and 48 h following EIMD (r = -.42; p < 0.05; r = -.57; p < 0.01 respectively). Our novel finding that sIL-6R concentrations are decreased 2-3 days following a single bout of EIMD may reflect a regulatory mechanism controlling the influx of different leukocyte subpopulations into damaged tissue, although this needs to be confirmed by future studies. Our data suggests an association between sIL-6R, perception of pain and reduced peak muscle performance post-EIMD but further investigation is warranted to explore this relationship and implications for exercise performance

Grouping of decathlon disciplines

The 10 disciplines in the decathlon can be broadly characterised as running, jumping and throwing. However, these simplistic characteristics may not represent the groupings defined by performances in the decathlon. The identification of groups may reveal a recondite advantage for athletes who excel in particular disciplines. Therefore this study used cluster analysis to determine the groupings inherent within the decathlon disciplines. The data set was derived from the top 173 decathletes between the years 1986 to 2005. Six clustering methods were applied to a Euclidean proximity matrix. The highest number of clusters common to all the methods was accepted as the solution. All six methods produced the same 3-cluster ([100m 400m 110H LJ PV HJ][SP DT JT][1500m]), 4-cluster ([100m 400m 110H LJ PV][SP DT JT][HJ][1500m]) and 5-cluster ([100m 400m 110mH LJ][SP DT JT][PV][HJ][1500m]) solutions. Stability tests confirmed the consistency of all the solutions. The 10 disciplines of the decathlon form into five groupings, which can be adequately explained from a physiological perspective. The clustering suggests that athletes who perform better at the sprint/track disciplines may obtain an advantage in the decathlon