The Board - A Place for Veterans to Build Their Professional Networks

I chose to complete a service-learning project where I created a website that allows veterans to build their professional networks. I also identified that veterans often have a hard time communicating their military qualifications on their resumes. This led to the creation of a forum on my website where veterans can submit their resumes and receive feedback from other veterans

Validation of PITCHAI Markerless Motion Capture Using Gold Standard 3D Motion Capture

Kinematic assessments in baseball pitchers have previously been determined using marker-based motion capture systems. No current research exists on the feasibility of single camera markerless motion capture technology for kinematic pitching analysis. This study sought to compare and validate pitching kinematics (joint angles, summary metrics) from a markerless motion capture solution with a gold standard, 3D optical marker-based solution. 38 elite-level healthy pitchers threw 1-3 maximum effort pitches while concurrently using marker-based optical capture and pitchAITM smartphone based (markerless) motion capture. Measures were compared using Pearson's R (R), R Squared (r2), and root mean square error (RMSE). Kinematics were evaluated at foot plant, maximal shoulder external rotation, ball release, and for descriptive metrics. For full time-series angles, pelvis and trunk averaged r2 of 0.92, and 6.0 ± 1.1° of RMSE. Knee angles averaged an r2 of 0.87 ± 0.08, and 8.8 ± 3.6° of RMSE. Throwing arm averaged an r2 of 0.88 ± 0.03, and 12.3 ± 4.2° of RMSE.  Glove arm averaged an r2 of 0.81 ± 0.09, and 14.1 ± 4.5° of RMSE. Most metrics were comparable to the gold standard. pitchAITM can be recommended as a markerless alternative to marker-based motion capture for pitching kinematic analysis.

DETERMINING RELATIONSHIPS BETWEEN KINEMATIC SEQUENCING AND BASEBALL PITCH VELOCITY USING MARKERLESS MOTION CAPTURE

The purpose of this study was to determine how the timings and magnitudes of peak pelvis rotational velocity, peak trunk rotational velocity, peak elbow extension velocity, and peak shoulder internal rotation velocity affect pitch velocity. Eighty pitchers (187.2 ± 8.2cm, 89.3 ± 13.0kg, 20.1 ± 3.3yrs) had a minimum of 3 fastballs recorded and video was processed using pitchAITM. Average pitch velocity was 38.1 ± 2.5 m/s. A multilinear regression generated a significant prediction for pitch velocity (R2 = 0.368 and p \u3c 0.01). Pitcher weight (β = 0.535, p \u3c 0.001), peak pelvis rotational velocity timing (β = -0.157, p = 0.001), peak elbow extension timing (β = 0.122, p = 0.006), and peak shoulder internal rotation timing (β = -0.113, p = 0.018), were significant contributors to the multilinear model. In conclusion, player weight and their kinematic sequence metrics from pitchAITM can be significant predictors of pitch velocity

A certified plasmid reference material for the standardisation of BCR-ABL1 mRNA quantification by real-time quantitative PCR

Serial quantification of BCR-ABL1 mRNA is an important therapeutic indicator in chronic myeloid leukemia, but there is substantial variation in results reported by different laboratories. To improve comparability, an internationally accepted plasmid certified reference material (CRM) was developed according to ISO Guide 34:2009. Fragments of BCR-ABL1 (e14a2 mRNA fusion), BCR and GUSB transcripts were amplified and cloned into pUC18 to yield plasmid pIRMM0099. Six different linearised plasmid solutions were produced with the following copy number concentrations, assigned by digital PCR, and expanded uncertainties: 1.08±0.13×106, 1.08±0.11×105, 1.03±0.10×104, 1.02±0.09×103, 1.04±0.10×102 and 10.0±1.5 copies/µL. The certification of the material for the number of specific DNA fragments per plasmid and the copy number concentration of the plasmid solutions and the assessment of inter-unit heterogeneity and stability were performed according to ISO Guide 35:2006. Two suitability studies performed by 63 BCR-ABL1 testing laboratories demonstrated that this set of 6 plasmid CRMs can help to standardise the numbers of measured transcripts of BCR-ABL1 and three control genes; ABL1, BCR and GUSB. The set of 6 plasmid CRMs is distributed worldwide by the Institute for Reference Materials and Measurements (Belgium) and its authorised distributors (http://irmm.jrc.ec.europa.eu; CRM code ERM-AD623a-f).JRC.D.2 - Standards for Innovation and sustainable Developmen

MPL mutations in myeloproliferative disorders: analysis of the PT-1 cohort

Activating mutations of MPL exon 10 have been described in a minority of patients with idiopathic myelofibrosis (IMF) or essential thrombocythemia (ET), but their prevalence and clinical significance are unclear. Here we demonstrate that MPL mutations outside exon 10 are uncommon in platelet cDNA and identify 4 different exon 10 mutations in granulocyte DNA from a retrospective cohort of 200 patients with ET or IMF. Allelespecific polymerase chain reaction was then used to genotype 776 samples from patients with ET entered into the PT-1 studies. MPL mutations were identified in 8.5% of JAK2 V617F ؊ patients and a single V617F ؉ patient. Patients carrying the W515K allele had a significantly higher allele burden than did those with the W515L allele, suggesting a functional difference between the 2 variants. Compared with V617F ؉ ET patients, those with MPL mutations displayed lower hemoglobin and higher platelet levels at diagnosis, higher serum erythropoietin levels, endogenous megakaryocytic but not erythroid colony growth, and reduced bone marrow erythroid and overall cellularity. Compared with V617F ؊ patients, those with MPL mutations were older with reduced bone marrow cellularity but could not be identified as a discrete clinicopathologic subgroup. MPL mutations lacked prognostic significance with respect to thrombosis, major hemorrhage, myelofibrotic transformation or survival. (Blood

Measurement of neutrino and antineutrino neutral-current quasielasticlike interactions on oxygen by detecting nuclear deexcitation γ rays

Neutrino- A nd antineutrino-oxygen neutral-current quasielasticlike interactions are measured at Super-Kamiokande using nuclear deexcitation γ rays to identify signal-like interactions in data from a 14.94(16.35)×1020 protons-on-target exposure of the T2K neutrino (antineutrino) beam. The measured flux-averaged cross sections on oxygen nuclei are âσν-NCQE

Simultaneous measurement of the muon neutrino charged-current cross section on oxygen and carbon without pions in the final state at T2K

This paper reports the first simultaneous measurement of the double differential muon neutrino charged-current cross section on oxygen and carbon without pions in the final state as a function of the outgoing muon kinematics, made at the ND280 off-axis near detector of the T2K experiment. The ratio of the oxygen and carbon cross sections is also provided to help validate various models\u27 ability to extrapolate between carbon and oxygen nuclear targets, as is required in T2K oscillation analyses. The data are taken using a neutrino beam with an energy spectrum peaked at 0.6 GeV. The extracted measurement is compared with the prediction from different Monte Carlo neutrino-nucleus interaction event generators, showing particular model separation for very forward-going muons. Overall, of the models tested, the result is best described using local Fermi gas descriptions of the nuclear ground state with RPA suppression

Search for CP Violation in Neutrino and Antineutrino Oscillations by the T2K Experiment with 2.2×1021 Protons on Target

The T2K experiment measures muon neutrino disappearance and electron neutrino appearance in accelerator-produced neutrino and antineutrino beams. With an exposure of 14.7(7.6)×1020 protons on target in the neutrino (antineutrino) mode, 89 νe candidates and seven anti-νe candidates are observed, while 67.5 and 9.0 are expected for δCP=0 and normal mass ordering. The obtained 2σ confidence interval for the CP-violating phase, δCP, does not include the CP-conserving cases (δCP=0, π). The best-fit values of other parameters are sin2θ23=0.526-0.036+0.032 and Δm322=2.463-0.070+0.071×10-3 eV2/c4

Constraint on the matter–antimatter symmetry-violating phase in neutrino oscillations

The charge-conjugation and parity-reversal (CP) symmetry of fundamental particles is a symmetry between matter and antimatter. Violation of this CP symmetry was first observed in 19641, and CP violation in the weak interactions of quarks was soon established2. Sakharov proposed3 that CP violation is necessary to explain the observed imbalance of matter and antimatter abundance in the Universe. However, CP violation in quarks is too small to support this explanation. So far, CP violation has not been observed in non-quark elementary particle systems. It has been shown that CP violation in leptons could generate the matter–antimatter disparity through a process called leptogenesis4. Leptonic mixing, which appears in the standard model’s charged current interactions5,6, provides a potential source of CP violation through a complex phase δCP, which is required by some theoretical models of leptogenesis7–9. This CP violation can be measured in muon neutrino to electron neutrino oscillations and the corresponding antineutrino oscillations, which are experimentally accessible using accelerator-produced beams as established by the Tokai-to-Kamioka (T2K) and NOvA experiments10,11. Until now, the value of δCP has not been substantially constrained by neutrino oscillation experiments. Here we report a measurement using long-baseline neutrino and antineutrino oscillations observed by the T2K experiment that shows a large increase in the neutrino oscillation probability, excluding values of δCP that result in a large increase in the observed antineutrino oscillation probability at three standard deviations (3σ). The 3σ confidence interval for δCP, which is cyclic and repeats every 2π, is [−3.41, −0.03] for the so-called normal mass ordering and [−2.54, −0.32] for the inverted mass ordering. Our results indicate CP violation in leptons and our method enables sensitive searches for matter–antimatter asymmetry in neutrino oscillations using accelerator-produced neutrino beams. Future measurements with larger datasets will test whether leptonic CP violation is larger than the CP violation in quarks