9,344 research outputs found
Building Engineering Feasibility Study: Herreshoff Marine Museum
Our design team was supplied with a dozen architectural designs from the students of the Roger Williams University Architectural School. After discussing the strengths and weaknesses of each our team was able to narrow our choices down to one base design to conduct our feasibility and structural integrity analysis. Currently, the structural integrity of the proposed building addition has been examined by determining the wind and the snow loads, the green roof requirements, and the column and beam loads. The feasibility of the chosen design was assessed by researching Bristol zoning regulations and developing a path through the required zoning variances, which will help in the construction phase
Multilevel Analysis of Trachomatous Trichiasis and Corneal Opacity in Nigeria : The Role of Environmental and Climatic Risk Factors on the Distribution of Disease.
Funding: Jennifer L Smith was supported by the International Trachoma Initiative through a grant from the Bill and Melinda Gates Foundation. Anthony Solomon is a Wellcome Trust Intermediate Clinical Fellow (098521). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD
Static and dynamic aeroelastic characterization of an aerodynamically heated generic hypersonic aircraft configuration
This work-in-progress presentation describes an ongoing research activity at the NASA Langley Research Center to develop analytical methods for the prediction of aerothermoelastic stability of hypersonic aircraft including active control systems. The objectives of this research include application of aerothermal loads to the structural finite element model, determination of the thermal effects on flutter, and assessment of active controls technology applied to overcome any potential adverse aeroelastic stability or response problems due to aerodynamic heating- namely flutter suppression and ride quality improvement. For this study, a generic hypersonic aircraft configuration was selected which incorporates wing flaps, ailerons and all-moveable fins to be used for active control purposes. The active control systems would use onboard sensors in a feedback loop through the aircraft flight control computers to move the surfaces for improved structural dynamic response as the aircraft encounters atmospheric turbulence
Active control of aerothermoelastic effects for a conceptual hypersonic aircraft
Procedures for and results of aeroservothermoelastic studies are described. The objectives of these studies were to develop the necessary procedures for performing an aeroelastic analysis of an aerodynamically heated vehicle and to analyze a configuration in the classical cold state and in a hot state. Major tasks include the development of the structural and aerodynamic models, open loop analyses, design of active control laws for improving dynamic responses and analyses of the closed loop vehicles. The analyses performed focused on flutter speed calculations, short period eigenvalue trends and statistical analyses of the vehicle response to controls and turbulence. Improving the ride quality of the vehicle and raising the flutter boundary of the aerodynamically-heated vehicle up to that of the cold vehicle were the objectives of the control law design investigations
A Tone-Aided/Dual Vestigial Sideband (TA/DVSB) system for mobile satellite channels
Tone-aided modulation is one way of combatting the effects of multipath fading and Doppler frequency shifts. A new tone-aided modulation format for M-ary phase-shift keyed signals (MPSK) is discussed. A spectral null for the placement of the tone is created in the center of the MPSK signal by translating the upper sideband upwards in frequency by the same amount. The key element of the system is the algorithm for recombining the data sidebands in the receiver, a function that is performed by a specialized phase-locked loop (PLL). The system structure is discussed and simulation results showing the PLL acquisition performance are presented
The Spitzer South Pole Telescope Deep Field Survey: Linking galaxies and halos at z=1.5
We present an analysis of the clustering of high-redshift galaxies in the
recently completed 94 deg Spitzer-SPT Deep Field survey. Applying flux and
color cuts to the mid-infrared photometry efficiently selects galaxies at
in the stellar mass range , making this
sample the largest used so far to study such a distant population. We measure
the angular correlation function in different flux-limited samples at scales
(corresponding to physical distances Mpc) and
thereby map the one- and two-halo contributions to the clustering. We fit halo
occupation distributions and determine how the central galaxy's stellar mass
and satellite occupation depend on the halo mass. We measure a prominent peak
in the stellar-to-halo mass ratio at a halo mass of , 4.5 times higher than the value. This supports
the idea of an evolving mass threshold above which star formation is quenched.
We estimate the large-scale bias in the range and the satellite
fraction to be , showing a clear evolution compared to
. We also find that, above a given stellar mass limit, the fraction of
galaxies that are in similar mass pairs is higher at than at . In
addition, we measure that this fraction mildly increases with the stellar mass
limit at , which is the opposite of the behavior seen at low-redshift.Comment: 32 pages, 22 figures. Published in MNRA
Reducing the Effects of PCR Amplification and Sequencing Artifacts on 16S rRNA-Based Studies
The advent of next generation sequencing has coincided with a growth in interest in using these approaches to better understand the role of the structure and function of the microbial communities in human, animal, and environmental health. Yet, use of next generation sequencing to perform 16S rRNA gene sequence surveys has resulted in considerable controversy surrounding the effects of sequencing errors on downstream analyses. We analyzed 2.7×10[superscript 6] reads distributed among 90 identical mock community samples, which were collections of genomic DNA from 21 different species with known 16S rRNA gene sequences; we observed an average error rate of 0.0060. To improve this error rate, we evaluated numerous methods of identifying bad sequence reads, identifying regions within reads of poor quality, and correcting base calls and were able to reduce the overall error rate to 0.0002. Implementation of the PyroNoise algorithm provided the best combination of error rate, sequence length, and number of sequences. Perhaps more problematic than sequencing errors was the presence of chimeras generated during PCR. Because we knew the true sequences within the mock community and the chimeras they could form, we identified 8% of the raw sequence reads as chimeric. After quality filtering the raw sequences and using the Uchime chimera detection program, the overall chimera rate decreased to 1%. The chimeras that could not be detected were largely responsible for the identification of spurious operational taxonomic units (OTUs) and genus-level phylotypes. The number of spurious OTUs and phylotypes increased with sequencing effort indicating that comparison of communities should be made using an equal number of sequences. Finally, we applied our improved quality-filtering pipeline to several benchmarking studies and observed that even with our stringent data curation pipeline, biases in the data generation pipeline and batch effects were observed that could potentially confound the interpretation of microbial community data.National Institutes of Health (U.S.) (1R01HG005975-01)National Science Foundation (U.S.) (award #0743432)National Institutes of Health (U.S.) (grant NIHU54HG004969
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