Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.

BACKGROUND: Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) countries worldwide. METHODS: This is a multicenter, international prospective cohort study. Consecutive sampling of patients undergoing emergency appendectomy over 6 months was conducted. Follow-up lasted 30 days. RESULTS: 4546 patients from 52 countries underwent appendectomy (2499 high-, 1540 middle-, and 507 low-HDI groups). Surgical site infection (SSI) rates were higher in low-HDI (OR 2.57, 95% CI 1.33-4.99, p = 0.005) but not middle-HDI countries (OR 1.38, 95% CI 0.76-2.52, p = 0.291), compared with high-HDI countries after adjustment. A laparoscopic approach was common in high-HDI countries (1693/2499, 67.7%), but infrequent in low-HDI (41/507, 8.1%) and middle-HDI (132/1540, 8.6%) groups. After accounting for case-mix, laparoscopy was still associated with fewer overall complications (OR 0.55, 95% CI 0.42-0.71, p < 0.001) and SSIs (OR 0.22, 95% CI 0.14-0.33, p < 0.001). In propensity-score matched groups within low-/middle-HDI countries, laparoscopy was still associated with fewer overall complications (OR 0.23 95% CI 0.11-0.44) and SSI (OR 0.21 95% CI 0.09-0.45). CONCLUSION: A laparoscopic approach is associated with better outcomes and availability appears to differ by country HDI. Despite the profound clinical, operational, and financial barriers to its widespread introduction, laparoscopy could significantly improve outcomes for patients in low-resource environments. TRIAL REGISTRATION: NCT02179112

ATLAS data quality operations and performance for 2015-2018 data-taking

The ATLAS detector at the Large Hadron Collider reads out particle collision data from over 100 million electronic channels at a rate of approximately 100 kHz, with a recording rate for physics events of approximately 1 kHz. Before being certified for physics analysis at computer centres worldwide, the data must be scrutinised to ensure they are clean from any hardware or software related issues that may compromise their integrity. Prompt identification of these issues permits fast action to investigate, correct and potentially prevent future such problems that could render the data unusable. This is achieved through the monitoring of detector-level quantities and reconstructed collision event characteristics at key stages of the data processing chain. This paper presents the monitoring and assessment procedures in place at ATLAS during 2015–2018 data-taking. Through the continuous improvement of operational procedures, ATLAS achieved a high data quality efficiency, with 95.6% of the recorded proton-proton collision data collected at √s=13 TeV certified for physics analysis.Fil: Orellana, Gonzalo Enrique. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Alconada Verzini, María Josefina. Tel Aviv University; Israel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Arduh, Francisco Anuar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Dova, Maria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Monticelli, Fernando Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Hoya, Joaquín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Wahlberg, Hernan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Abed Abud, A.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Ahmad, A.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Alderweireldt, S.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Aleksa, M.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Allaire, C.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Aranzabal Barrio, N.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Bielski, R.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Bortfeldt, J.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Boyd, J.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Butti, P.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Buttinger, W.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Camincher, C.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Campana, S.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Ellis, N.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Elsing, M.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Farthouat, P.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Fassnacht, P.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Heinrich, L.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Iengo, P.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Morley, A. K.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Mornacchi, G. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Moschovakos, P.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Meehan, S.. Cern - European Organization For Nuclear Research. The Cern Council; Suiz

Search for pairs of scalar leptoquarks decaying into quarks and electrons or muons in s√s = 13 TeV pp collisions with the ATLAS detector

A search for new-physics resonances decaying into a lepton and a jet performed by the ATLAS experiment is presented. Scalar leptoquarks pair-produced in pp collisions at s√ = 13 TeV at the Large Hadron Collider are considered using an integrated luminosity of 139 fb−1, corresponding to the full Run 2 dataset. They are searched for in events with two electrons or two muons and two or more jets, including jets identified as arising from the fragmentation of c- or b-quarks. The observed yield in each channel is consistent with the Standard Model background expectation. Leptoquarks with masses below 1.8 TeV and 1.7 TeV are excluded in the electron and muon channels, respectively, assuming a branching ratio into a charged lepton and a quark of 100%, with minimal dependence on the quark flavour. Upper limits on the aforementioned branching ratio are also given as a function of the leptoquark mass.Fil: Alonso, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Alconada Verzini, María Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina. Universitat Tel Aviv; IsraelFil: Arduh, Francisco Anuar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Dova, Maria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Hoya, Joaquín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Monticelli, Fernando Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Orellana, Gonzalo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Wahlberg, Hernan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Abed Abud, A.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Ahmad, A.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Alderweireldt, S.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Aleksa, M.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Allaire, C.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Aranzabal Barrio, N.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Bielski, R.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Bortfeldt, J.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Boyd, J.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Butti, P.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Buttinger, W.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Camincher, C.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Campana, S.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Ellis, N.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Elsing, M.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Farthouat, P.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Fassnacht, P.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Heinrich, L.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Iengo, P.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Morley, A. K.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Mornacchi, G.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Moschovakos, P.. Cern - European Organization For Nuclear Research. The Cern Council; Suiz

Performance of electron and photon triggers in ATLAS during LHC Run 2.

Electron and photon triggers covering transverse energies from 5 GeV to several TeV are essential for the ATLAS experiment to record signals for a wide variety of physics: from Standard Model processes to searches for new phenomena in both proton–proton and heavy-ion collisions. To cope with a fourfold increase of peak LHC luminosity from 2015 to 2018 (Run 2), to 2.1×1034 cm−2 s −1 , and a similar increase in the number of interactions per beam-crossing to about 60, trigger algorithms and selections were optimised to control the rates while retaining a high efficiency for physics analyses. For proton–proton collisions, the single-electron trigger efficiency relative to a single-electron offline selection is at least 75% for an offline electron of 31 GeV, and rises to 96% at 60 GeV; the trigger efficiency of a 25 GeV leg of the primary diphoton trigger relative to a tight offline photon selection is more than 96% for an offline photon of 30 GeV. For heavy-ion collisions, the primary electron and photon trigger efficiencies relative to the corresponding standard offline selections are at least 84% and 95%, respectively, at 5 GeV above the corresponding trigger threshold.Fil: Wahlberg, Hernan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Alconada Verzini, María Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina. Universitat Tel Aviv; IsraelFil: Alonso, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Arduh, Francisco Anuar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Dova, Maria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Hoya, Joaquín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Monticelli, Fernando Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Orellana, Gonzalo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Abed Abud, A.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Ahmad,A.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Alderweireldt, S.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Aleksa, M.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Allaire, C.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Aranzabal Barrio, N.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Bielski, R.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Bortfeldt, J.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Boyd, J.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Butti, P.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Buttinger, W.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Camincher, C.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Campana, S.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Ellis, N.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Elsing, M.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Morley, A. K.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Mornacchi, G.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Moschovakos, P.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Meehan, S.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Meng, L.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Stewart, G. A.. Cern - European Organization For Nuclear Research. The Cern Council; SuizaFil: Stockton, M. C.. Cern - European Organization For Nuclear Research. The Cern Council; Suiz

Differential cross-section measurements for the electroweak production of dijets in association with a Z boson in proton–proton collisions at ATLAS

Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UA

Optimisation of large-radius jet reconstruction for the ATLAS detector in 13 TeV proton–proton collisions

Jet substructure has provided new opportunities for searches and measurements at the LHC, and has seen continuous development since the optimization of the large-radius jet definition used by ATLAS was performed during Run 1. A range of new inputs to jet reconstruction, pile-up mitigation techniques and jet grooming algorithms motivate an optimisation of large-radius jet reconstruction for ATLAS. In this paper, this optimisation procedure is presented, and the performance of a wide range of large-radius jet definitions is compared. The relative performance of these jet definitions is assessed using metrics such as their pileup stability, ability to identify hadronically decaying W bosons and top quarks with large transverse momenta. A new type of jet input object, called a ‘unified flow object’ is introduced which combines calorimeter- and inner-detector-based signals in order to achieve optimal performance across a wide kinematic range. Large-radius jet definitions are identified which significantly improve on the current ATLAS baseline definition, and their modelling is studied using pp collisions recorded by the ATLAS detector at \sqrt{s}=13~\text {TeV} during 2017

Differential tt¯cross-section measurements using boosted top quarks in the all-hadronic final state with 139 fb−1 of ATLAS data

Measurements of single-, double-, and triple-differential cross-sections are presented for boosted top-quark pair-production in 13 TeV proton–proton collisions recorded by the ATLAS detector at the LHC. The top quarks are observed through their hadronic decay and reconstructed as large-radius jets with the leading jet having transverse momentum (pT) greater than 500 GeV. The observed data are unfolded to remove detector effects. The particle-level cross-section, multiplied by the tt¯ → WWbb¯ branching fraction and measured in a fiducial phase space defined by requiring the leading and second-leading jets to have pT> 500 GeV and pT> 350 GeV, respectively, is 331 ± 3(stat.) ± 39(syst.) fb. This is approximately 20% lower than the prediction of 398−49+48 fb by Powheg+Pythia 8 with next-to-leading-order (NLO) accuracy but consistent within the theoretical uncertainties. Results are also presented at the parton level, where the effects of top-quark decay, parton showering, and hadronization are removed such that they can be compared with fixed-order next-to-next-to-leading-order (NNLO) calculations. The parton-level cross-section, measured in a fiducial phase space similar to that at particle level, is 1.94 ± 0.02(stat.) ± 0.25(syst.) pb. This agrees with the NNLO prediction of 1.96−0.17+0.02 pb. Reasonable agreement with the differential cross-sections is found for most NLO models, while the NNLO calculations are generally in better agreement with the data. The differential cross-sections are interpreted using a Standard Model effective field-theory formalism and limits are set on Wilson coefficients of several four-fermion operators. [Figure not available: see fulltext.]

Search for dark matter in events with missing transverse momentum and a Higgs boson decaying into two photons in pp collisions at √s = 13 TeV with the ATLAS detector

A search for dark-matter particles in events with large missing transverse momentum and a Higgs boson candidate decaying into two photons is reported. The search uses $139$ fb$^{-1}$ of proton-proton collision data collected at $\sqrt{s}=13$ TeV with the ATLAS detector at the CERN LHC between 2015 and 2018. No significant excess of events over the Standard Model predictions is observed. The results are interpreted by extracting limits on three simplified models that include either vector or pseudoscalar mediators and predict a final state with a pair of dark-matter candidates and a Higgs boson decaying into two photons

Search for flavour-changing neutral current interactions of the top quark and the Higgs boson in events with a pair of τ-leptons in pp collisions at √s = 13 TeV with the ATLAS detector

A search for flavour-changing neutral current (FCNC) tqH interactions involving a top quark, another up-type quark (q = u, c), and a Standard Model (SM) Higgs boson decaying into a τ-lepton pair (H → τ + τ −) is presented. The search is based on a dataset of pp collisions at s = 13 TeV that corresponds to an integrated luminosity of 139 fb −1 recorded with the ATLAS detector at the Large Hadron Collider. Two processes are considered: single top quark FCNC production in association with a Higgs boson (pp → tH), and top quark pair production in which one of top quarks decays into Wb and the other decays into qH through the FCNC interactions. The search selects events with two hadronically decaying τ-lepton candidates (τ had) or at least one τ had with an additional lepton (e, μ), as well as multiple jets. Event kinematics is used to separate signal from the background through a multivariate discriminant. A slight excess of data is observed with a significance of 2.3σ above the expected SM background, and 95% CL upper limits on the t → qH branching ratios are derived. The observed (expected) 95% CL upper limits set on the t → cH and t → uH branching ratios are 9.4×10−4(4.8−1.4+2.2×10−4) and 6.9×10−4(3.5−1.0+1.5×10−4) , respectively. The corresponding combined observed (expected) upper limits on the dimension-6 operator Wilson coefficients in the effective tqH couplings are Ccϕ < 1.35 (0.97) and Cuϕ < 1.16 (0.82). [Figure not available: see fulltext.

Search for tt¯ H/ A→ tt¯ tt¯ production in the multilepton final state in proton–proton collisions at √s = 13 TeV with the ATLAS detector

A search for a new heavy scalar or pseudo-scalar Higgs boson (H/A) produced in association with a pair of top quarks, with the Higgs boson decaying into a pair of top quarks (H/A → tt¯) is reported. The search targets a final state with exactly two leptons with same-sign electric charges or at least three leptons. The analysed dataset corresponds to an integrated luminosity of 139 fb −1 of proton–proton collisions collected at a centre-of-mass energy of 13 TeV with the ATLAS detector at the LHC. Two multivariate classifiers are used to separate the signal from the background. No significant excess of events over the Standard Model expectation is observed. The results are interpreted in the context of a type-II two-Higgs-doublet model. The observed (expected) upper limits at 95% confidence level on the tt¯ H/ A production cross-section times the branching ratio of H/A → tt¯ range between 14 (10) fb and 6 (5) fb for a heavy Higgs boson with mass between 400 GeV and 1000 GeV, respectively. Assuming that only one particle, either the scalar H or the pseudo-scalar A, contributes to the tt¯ tt¯ final state, values of tan β below 1.2 or 0.5 are excluded for a mass of 400 GeV or 1000 GeV, respectively. These exclusion ranges increase to tan β below 1.6 or 0.6 when both particles are considered. [Figure not available: see fulltext.