Security awareness and affective feedback:categorical behaviour vs. reported behaviour

A lack of awareness surrounding secure online behaviour can lead to end-users, and their personal details becoming vulnerable to compromise. This paper describes an ongoing research project in the field of usable security, examining the relationship between end-user-security behaviour, and the use of affective feedback to educate end-users. Part of the aforementioned research project considers the link between categorical information users reveal about themselves online, and the information users believe, or report that they have revealed online. The experimental results confirm a disparity between information revealed, and what users think they have revealed, highlighting a deficit in security awareness. Results gained in relation to the affective feedback delivered are mixed, indicating limited short-term impact. Future work seeks to perform a long-term study, with the view that positive behavioural changes may be reflected in the results as end-users become more knowledgeable about security awareness

Assessing the impact of affective feedback on end-user security awareness

A lack of awareness regarding online security behaviour can leave users and their devices vulnerable to compromise. This paper highlights potential areas where users may fall victim to online attacks, and reviews existing tools developed to raise users’ awareness of security behaviour. An ongoing research project is described, which provides a combined monitoring solution and affective feedback system, designed to provide affective feedback on automatic detection of risky security behaviour within a web browser. Results gained from the research conclude an affective feedback mechanism in a browser-based environment, can promote general awareness of online security

Reducing risky security behaviours:utilising affective feedback to educate users

Despite the number of tools created to help end-users reduce risky security behaviours, users are still falling victim to online attacks. This paper proposes a browser extension utilising affective feedback to provide warnings on detection of risky behaviour. The paper provides an overview of behaviour considered to be risky, explaining potential threats users may face online. Existing tools developed to reduce risky security behaviours in end-users have been compared, discussing the success rate of various methodologies. Ongoing research is described which attempts to educate users regarding the risks and consequences of poor security behaviour by providing the appropriate feedback on the automatic recognition of risky behaviour. The paper concludes that a solution utilising a browser extension is a suitable method of monitoring potentially risky security behaviour. Ultimately, future work seeks to implement an affective feedback mechanism within the browser extension with the aim of improving security awareness

Effect of the Healthy Schools Program on prevalence of overweight and obesity in California schools, 2006-2012.

IntroductionThe Alliance for a Healthier Generation's Healthy Schools Program (HSP) is a national evidence-based obesity-prevention initiative aimed at providing the schools in greatest need with onsite training and technical assistance (TTA) and consultation with national experts (HSP national advisors) to create sustainable healthy change in schools' nutrition and physical activity environments. The objective of this study was to evaluate the impact of HSP on the prevalence of overweight and obesity in California schools, from HSP's inception in 2006 through 2012.MethodsWe used statewide body mass index (BMI) data collected annually from 5th-, 7th-, and 9th-grade students to determine whether enrolling in the HSP's onsite intervention reduced the prevalence of overweight and obesity in intervention schools (n = 281) versus propensity-score matched control schools (n = 709) and whether increasing exposure to the program (TTA and contact with HSP national advisors) was associated with reductions in the prevalence of overweight and obesity.ResultsAnalyses showed no difference between HSP schools and control schools in overweight or obesity prevalence. However, program exposure varied widely among participating schools, and each additional contact with TTA or HSP national advisors was associated with a 0.3% decline in overweight and obesity prevalence (P < .05).ConclusionHSP appears to be an important means of supporting schools in reducing obesity. Although participation in HSP alone was not sufficient to improve weight status in California schools, there was a clear dose-response relationship to the program. HSP serves as an effective model for addressing childhood obesity among engaged schools

Preliminary results of investigations into the use of artificial neural networks for discriminating gas chromatograph mass spectra of remote samples

Neural networks trained using mass spectra data from the National Institute of Standards and Technology (NIST) are studied. The investigations also included sample data from the gas chromatograph mass spectrometer (GCMS) instrument aboard the Viking Lander, obtained from the National Space Science Data Center. The work performed to data and the preliminary results from the training and testing of neural networks are described. These preliminary results are presented for the purpose of determining the viability of applying artificial neural networks in discriminating mass spectra samples from remote instrumentation such as the Mars Rover Sample Return Mission and the Cassini Probe

Detection of quantitative trait loci for locomotion and osteochondrosis-related traits in Large White x Meishan pigs.

Data from the F2 generation of a Large White (LW) 5 Meishan (MS) crossbred population were analysed to detect quantitative trait loci (QTL) for leg and gait scores, osteochondrosis and physis scores. Legs, feet and gait score were assessed in 308 F2 animals at 85 (± 5) kg and osteochondrosis and physis scores were recorded for the right foreleg after slaughter. A genome scan was performed using 111 genetic markers chosen to span the genome that were genotyped on the F2 animals and their F1 parents and purebred grandparents. A QTL on chromosome 1 affecting gait score was significant at the genome-wide significance level. Additional QTL significant at the chromosome-wide 5% threshold level (approx. equivalent to the genome-wide suggestive level) were detected on chromosome 1 for front feet and back legs scores, on chromosome 13 for front legs and front feet scores, on chromosome 14 for front legs, front feet and back legs scores and on chromosome 15 for back feet score. None of the QTL for osteochondrosis score exceeded the chromosome-wide suggestive level, but one chromosome-wide QTL for physis score was found on chromosome 7. On chromosome 1, gait and front feet scores mapped to the middle of the chromosome and showed additive effects in favour of the LW alleles and no dominance effects. The QTL for back legs score mapped to the distal end of the chromosome and showed a dominant effect and no additive effect. On chromosomes 14 and 15, the LW allele was again superior to the MS allele. On chromosome 13, there were both additive and dominance effects in favour of the MS allele. The MS alleles on chromosome 13 may have potential for introgression into a commercial LW population. The other putative QTLs identified may have value in marker-assisted selection in LW or MS-synthetic populations

Development of a novel polyamide-based agent to inhibit EVI1 function

The EVI1 gene at chromosome 3q26 is associated with acute myeloid leukemogenesis, due to both chromosomal rearrangement and to overexpression in the absence of rearrangement. Some rearrangements such as t(3;3) and inv(3) result in overexpression of EVI1 protein, while translocation t(3;21) yields an AML1-MDS1-EVI1 (AME) fusion protein. EVI1 possesses two zinc finger domains, an N-terminal domain with fingers 1–7, which binds to GACAAGATA, and a C-terminal domain (fingers 8–10) which binds GAAGATGAG. Inhibition of EVI1 function with a small molecule compound may provide a targeted therapy for EVI1-expressing leukemias. As a first step towards inhibiting the leukemogenic function of EVI1, we performed structure-function studies on both EVI1 and AME protein to determine what domains are critical for malignant transformation activity. Assays were Rat1 fibroblasts in a soft agar colony forming assay for EVI1; primary bone marrow cells in a serial replating assay for AME. Both assays revealed that mutation of arginine 205 in zinc finger 6 of EVI1, which completely abrogates sequencespecific DNA binding via the N-terminal zinc finger domain, resulted in complete loss of transforming activity; mutations in other domains, such as the C-terminal zinc finger domain, CtBP binding domain, and the domains of AML1 had less of an effect or no effect on transforming activity. In an effort to inhibit EVI1 leukemogenic function, we developed a polyamide, DH-IV-298, designed to block zinc fingers 1–7 binding to the GACAAGATA motif. DNAseI footprinting revealed a specific interaction between DH-IV-298 and the GACAAGATA motif; no significant interaction was observed elsewhere; a mismatch polyamide failed to footprint at equivalent concentrations; and DH-IV-298 failed to bind to a control DNA lacking the GACAAGATA motif. Electromobility shift assay showed that, at a 1:1 polyamide:DNA ratio, DH-IV-298 lowered EVI1:DNA affinity by over 98%, while mismatch was significantly less effective (74% reduction). To assess the effect of DH-IV-298 on EVI1 binding to DNA in vivo, we performed CAT reporter assays in a NIH-3T3-derived cell line with a chromosome-embedded tet-inducible EVI1-VP16 as well as a EVI1-responsive CAT reporter. Removal of tetracycline resulted in a four-fold increase in CAT activity that was completely blocked by DH-IV-298. The mismatch polyamide was significantly less effective than DH-IV-298. Further studies are being performed to assess the effect on endogenous gene expression, and on growth of leukemic cells that express EVI1. These studies provide evidence that a cell permeable small molecule compound may effectively block the activity of a leukemogenic transcription factor

Red Noise in Anomalous X-ray Pulsar Timing Residuals

Anomalous X-ray Pulsars (AXPs), thought to be magnetars, exhibit poorly understood deviations from a simple spin-down called "timing noise". AXP timing noise has strong low-frequency components which pose significant challenges for quantification. We describe a procedure for extracting two quantities of interest, the intensity and power spectral index of timing noise. We apply this procedure to timing data from three sources: a monitoring campaign of five AXPs, observations of five young pulsars, and the stable rotator PSR B1937+21.Comment: submitted to the proceedings of the "40 Years of Pulsars" conferenc

X-ray Observations of XSS J12270-4859 in a New Low State: A Transformation to a Disk-Free Rotation-Powered Pulsar Binary

We present XMM-Newton and Chandra observations of the low-mass X-ray binary XSS J12270--4859, which experienced a dramatic decline in optical/X-ray brightness at the end of 2012, indicative of the disappearance of its accretion disk. In this new state, the system exhibits previously absent orbital-phase-dependent, large-amplitude X-ray modulations with a decline in flux at superior conjunction. The X-ray emission remains predominantly non-thermal but with an order of magnitude lower mean luminosity and significantly harder spectrum relative to the previous high flux state. This phenomenology is identical to the behavior of the radio millisecond pulsar binary PSR J1023+0038 in the absence of an accretion disk, where the X-ray emission is produced in an intra-binary shock driven by the pulsar wind. This further demonstrates that XSS J12270-4859 no longer has an accretion disk and has transformed to a full-fledged eclipsing "redback" system that hosts an active rotation-powered millisecond pulsar. There is no evidence for diffuse X-ray emission associated with the binary that may arise due to outflows or a wind nebula. An extended source situated 1.5' from XSS J12270--4859 is unlikely to be associated, and is probably a previously uncatalogued galaxy cluster.Comment: 8 pages, 6 figures; accepted for publication in the Astrophysical Journa

The relationship and effects of golf on physical and mental health:A scoping review protocol

Introduction Golf is a sport played in 206 countries worldwide by over 50 million people. It is possible that participation in golf, which is a form of physical activity, may be associated with effects on longevity, the cardiovascular, metabolic and musculoskeletal systems, as well as on mental health and well-being. We outline our scoping review protocol to examine the relationships and effects of golf on physical and mental health. Methods and analysis Best practice methodological frameworks suggested by Arksey and O'Malley, Levac et al and the Joanna Briggs Institute will serve as our guide, providing clarity and rigour. A scoping review provides a framework to (1) map the key concepts and evidence, (2) summarise and disseminate existing research findings to practitioners and policymakers and (3) identify gaps in the existing research. A three-step search strategy will identify reviews as well as original research, published and grey literature. An initial search will identify suitable search terms, followed by a search using keyword and index terms. Two reviewers will independently screen identified studies for final inclusion. Dissemination We will map key concepts and evidence, and disseminate existing research findings to practitioners and policymakers through peer-reviewed and non-peer reviewed publications, conferences and inperson communications. We will identify priorities for further study. This method may prove useful to examine the relationships and effects of other sports on health.</p