New light on the S235A-B star forming region

The S235A-B star forming region has been extensively observed in the past from the radio to the near-IR, but what was happening in the immediate surroundings of the water maser, placed in between the two nebulosities, was still unclear because of insufficient resolution especially in the spectral range from the Far-IR to the mm, even though there were sound indications that new young stellar objects (YSOs) are being formed there. We present here new high resolution maps at mm wavelengths in different molecules (HCO+, C34S, H2CS, SO2 and CH3CN), as well as in the 1.2 and 3.3 mm continuum obtained with the Plateau de Bure interferometer, and JCMT observations at 450 micron and 850 micron that unambiguously reveal the presence of new YSOs placed in between the two HII regions S235A and S235B and associated with the water maser. A molecular core and an unresolved source in the mm and in the sub-mm are centred on the maser, with indication of mass infall onto the core. Two molecular bipolar outflows and a jet originate from the same position. Weak evidence is found for a molecular rotating disk perpendicular to the direction of the main bipolar outflow. The derived parameters indicate that one of the YSOs is an intermediate luminosity object (L~1000 Lsun) in a very early evolutionary phase, embedded in a molecular core of ~100 Msun, with a temperature of 30 K. The main source of energy for the YSO could come from gravitational infall, thus making of this YSO a rare example of intermediate luminosity protostar representing a link between the earliest evolutionary phases of massive stars and low mass protostars of class 0-I.Comment: 19 pages, 22 figures, to be published in Astronomy & Astrophysic

Fourier Transform Spectroscopy of the submillimetre continuum emission from hot molecular cores

We have used a Fourier Transform Spectrometer on the James Clerk Maxwell Telescope to study the submillimetre continuum emission from dust in three hot molecular cores (HMC). The spectral index beta of the dust emission for these sources has been determined solely within the 30 GHz wide 350 GHz (850 micron) passband to an accuracy comparable to those determined through multi-wavelength observations. We find an average beta = 1.6, in agreement with spectral indices determined from previous submillimetre observations of these sources and with those determined for HMC in general. The largest single source of uncertainty in these results is the variability of the atmosphere at 350 GHz, and with better sky subtraction techniques we show that the dust spectral index can clearly be determined within one passband to high accuracy with a submillimetre FTS. Using an imaging FTS on SCUBA-2, the next generation wide-field submillimetre camera currently under development to replace SCUBA at the JCMT in 2006, we calculate that at 350 GHz it will be possible to determine beta to +/- 0.1 for sources as faint as 400 mJy/beam and to +/- 0.3 for sources as faint as 140 mJy/beam.Comment: 11 pages, 5 figures, accepted for publication in MNRA

The Prepositions of the New Testament, with Illustrations from the Papyri

The thesis falls into three parts: 1. An introduction on the importance of the prepositions of the N.T. 2. A general consideration of the N.T. representatives in the light of ancient and modern Greek. 3. A detailed exposition with illustrations from the Papyri. The last and by far the largest section embodice the results of my own researches except where sometimes I have drawn upon the dissertations of Hoenberg and Kuhring who used collections to which I had not access. The middle section is perhaps the least original; but even there I hope it leaves the impression of having gone through my own mill

Improving care for people with dementia: development and initial feasibility study for evaluation of life story work in dementia care

Background: Improving dementia care quality is an urgent priority nationally and internationally. Life story work (LSW) is an intervention that aims to improve individual outcomes and care for people with dementia and their carers. LSW gathers information and artefacts about the person, their history and interests, and produces a tangible output: the ‘life story’. Objective: To establish whether or not full evaluation of LSW was feasible. Design: Mixed-methods feasibility study. Methods: In-depth interviews and focus groups explored experiences of LSW and best practice with people with dementia, family members and dementia care staff. A systematic review explored best practice and theories of change for LSW. These stages helped to identify the outcomes and resources to explore in the feasibility study. A representative sample survey of health and social care dementia care providers in England established LSW practice in different settings. A survey of a self-selected sample of family members of people with dementia explored how LSW is experienced. Two small outcome studies (stepped-wedge study in six care homes and pre-test post-test study in inpatient specialist dementia care wards) explored the feasibility of full evaluation of LSW in these settings. Settings: Survey: generalist and specialist care homes; NHS dementia care settings; and community dementia services. Feasibility study: care homes and NHS inpatient dementia care wards. Participants: NHS and social care services, people with dementia, family carers, care home staff and NHS staff. Interventions: LSW. Main outcome measures: Spread of LSW and good practice, quality of life (QoL) for the person with dementia and carers, relationships between people with dementia and family carers, staff attitudes about dementia, staff burnout, resource use and costs. Review methods: Narrative review and synthesis, following Centre for Review and Dissemination guidelines. Results: Good practice in LSW is identifiable, as are theories of change about how it might affect given outcomes. Indicators of best practice were produced. LSW is spreading but practice and use vary between care settings and are not always in line with identified good practice. Two different models of LSW are evident; these are likely to be appropriate at different stages of the dementia journey. The feasibility study showed some positive changes in staff attitudes towards dementia and, for some people with dementia, improvements in QoL. These may be attributable to LSW but these potential benefits require full evaluation. The feasibility work established the likely costs of LSW and highlighted the challenges of future evaluation in care homes and inpatient dementia care settings. Limitations: There was insufficient evidence in the literature to allow estimation of outcome size. We did not carry out planned Markov chain modelling to inform decisions about carrying out future evaluation because of the dearth of outcome data in the literature; low levels of data return for people with dementia in the hospital settings; lack of detected effect for most people with dementia; and questions about implementation in the research settings. Conclusions: LSW is used across different health and social care settings in England, but in different ways, not all of which reflect ‘good practice’. This large, complex study identified a wide range of challenges for future research, but also the possibility that LSW may help to improve care staff attitudes towards dementia and QoL for some people with dementia. Future work: Full evaluation of LSW as an intervention to improve staff attitudes and care is feasible with researchers based in or very close to care settings to ensure high-quality data collection. Funding: The National Institute for Health Research Health Services and Delivery Research programme. Keywords

Vulnerability to fuel price increases in the UK: A household level analysis

In highly motorised countries, some sectors of the population own and use cars despite struggling to afford their running costs, and so may be particularly vulnerable to motor fuel prices increases, whether market-led or policy-driven. This paper proposes a novel, disaggregated approach to investigating vulnerability to such increases at the household level. We propose a set of indicators of ‘car-related economic stress’ (CRES), based on individual household level expenditure data for the UK, to identify which low-income households spend disproportionately on running motor vehicles, and to assess the depth of their economic stress. By subsequently linking the dataset to local fuel price data, we are able to model the disaggregated price elasticities of car fuel demand. This provides us with an indicator of each households’ adaptive capacity to fuel price increases. The findings show that ‘Low-Income, High Cost’ households (LIHC) account for 9% of UK households and have distinct socio-demographic characteristics. Interestingly, they are characterised by very low responses to fuel price increases, which may cause them to compromise on other important areas of their household expenditures. Simulations suggest that a 20% increase in fuel prices would substantially increase the depth, but not the incidence of CRES. Overall, the study sheds light on a sector of the population with high levels of vulnerability to fuel price increases, owing to high exposure, high sensitivity and low adaptive capacity. This raises challenges for social, environmental and resilience policy in the transport sector

Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation : Data From ROCKET AF

M. Kaste on työryhmän ROCKET AF Steering Comm jäsen.Background-Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all-cause mortality may guide interventions. Methods and Results-In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) study, patients with nonvalvular atrial fibrillation were randomized to rivaroxaban or dose-adjusted warfarin. Cox proportional hazards regression with backward elimination identified factors at randomization that were independently associated with all-cause mortality in the 14 171 participants in the intention-to-treat population. The median age was 73 years, and the mean CHADS(2) score was 3.5. Over 1.9 years of median follow-up, 1214 (8.6%) patients died. Kaplan-Meier mortality rates were 4.2% at 1 year and 8.9% at 2 years. The majority of classified deaths (1081) were cardiovascular (72%), whereas only 6% were nonhemorrhagic stroke or systemic embolism. No significant difference in all-cause mortality was observed between the rivaroxaban and warfarin arms (P=0.15). Heart failure (hazard ratio 1.51, 95% CI 1.33-1.70, P= 75 years (hazard ratio 1.69, 95% CI 1.51-1.90, P Conclusions-In a large population of patients anticoagulated for nonvalvular atrial fibrillation, approximate to 7 in 10 deaths were cardiovascular, whereasPeer reviewe

The osteology of ‘Periptychus carinidens’: a robust, ungulate-like placental mammal (Mammalia: Periptychidae) from the Paleocene of North America

Periptychus is the archetypal genus of Periptychidae, a clade of prolific Paleocene 'condylarth' mammals from North America that were among the first placental mammals to radiate after the end-Cretaceous extinction, remarkable for their distinctive dental anatomy. A comprehensive understanding of the anatomy of Periptychus has been hindered by a lack of cranial and postcranial material and only cursory description of existing material. We comprehensively describe the cranial, dental and postcranial anatomy of Periptychus carinidens based on new fossil material from the early Paleocene (Torrejonian) of New Mexico, USA. The cranial anatomy of Periptychus is broadly concurrent with the inferred plesiomorphic eutherian condition, albeit more robust in overall construction. The rostrum is moderately elongate with no constriction, the facial region is broad, and the braincase is small with a well-exposed mastoid on the posterolateral corner and tall sagittal and nuchal crests. The dentition of Periptychus is characterized by strongly crenulated enamel, enlarged upper and lower premolars with a tall centralised paracone/protoconid. The postcranial skeleton of Periptychus is that of a robust, medium-sized (~20 Kg) stout-limbed animal that was incipiently mediportal and adopted a plantigrade stance. The structure of the fore- and hindlimb of Periptychus corresponds to that of a typically terrestrial mammal, while morphological features of the forelimb such as the low tubercles of the humerus, long and prominent deltopectoral crest, pronounced medial epicondyle, and hemispherical capitulum indicate some scansorial and/or fossorial ability. Most striking is the strongly dorsoplantarly compressed astragalus of Periptychus, which in combination with the distal crus and calcaneal morphology indicates a moderately mobile cruropedal joint. The anatomy of Periptychus is unique and lacks any extant analogue; it combines a basic early placental body plan with numerous unique specializations in its dental, cranial and postcranial anatomy that exemplify the ability of mammals to adapt and evolve following catastrophic environmental upheaval

On the lack of cold dust in IRAS P09104+4109 and IRAS F15307+3252 -- their spectral energy distributions and implications for finding dusty AGNs at high redshift

We present upper limits on the 850 micron and 450 micron fluxes of the warm hyperluminous (bolometric luminosity L_bol > 10^13 L_sun galaxies IRAS P09104+4109 (z=0.442) and IRAS F15307+3252 (z=0.926), derived from measurements using the SCUBA bolometer array on the James Clerk Maxwell Telescope. Hot luminous infrared sources like these are thought to differ from more normal cold ultraluminous infrared (L_bol > 10^12 L_sun) galaxies in that they derive most of their bolometric luminosities from dusty AGNs as opposed to starbursts. Such hot, dusty AGNs at high redshift are thought to be responsible for much of the mass accretion of the Universe that is in turn responsible for the formation of the supermassive black holes seen in the centres of local galaxies. The galaxy IRAS P09104+4109 is also unusual in that it is a cD galaxy in the center of a substantial cooling-flow cluster, not an isolated interacting galaxy like most ultraluminous infrared galaxies. Previously it was known to have large amounts of hot (T > 50 K) dust from IRAS observations. We now show that the contribution of cold dust to the bolometric luminosity is less than 3 per cent. Most ultraluminous infrared galaxies possess large amounts of cold dust, and it is now known that some cooling flow cluster cD galaxies do as well. Yet this object, which is an extreme example of both, does not have enough cold gas to contribute significantly to the bolometric luminosity. We outline physical reasons why this could have happened. We then provide a discussion of stategies for finding hot dusty AGNs, given the limitations on submillimetre surveys implied by this work.Comment: MNRAS in press, accepted version, minor revision