Pengaruh Komitmen dan Loyalitas Terhadap Kinerja Karyawan di Kantor PT. Perkebunan Nusantara IV Kantor Regional I

Karyawan milenial, atau sering disebut sebagai generasi Y, merujuk pada kelompok orang yang lahir sekitar tahun 1981 hingga 1996. Penelitian ini bertujuan untuk menguji pengaruh komitmen dan loyalitas terhadap kinerja karyawan. Sampel dalam penelitian ini adalah 65 karyawan.  Instrument  pengumpulan  data  menggunakan  kuesioner  dengan  skala  likert  yang masing-masing sudah diuji cobakan serta telah memenuhi syarat validitas dan reliabilitas. Analisis data menggunakan regresi linear berganda dengan menggunakan alat bantu software SPSS 18.0 for Windows. Hasil penelitian secara parsial menunjukkan bahwa kemapuan kerja berpengaruh positif dan signifikan secara parsial terhadap kinerja karyawan, komitmen kerja tidak berpengaruh signifikan secara parsial terhadap kinerja karyawan, kerja sama tim berpengaruh positif dan signifikan secara parsial terhadap kinerja karyawan. Hasil penelitian secara simultan menunjukkan bahwa komitmen berpengaruh positif dan signifikan secara parsial terhadap kinerja karyawan, loyalitas berpengaruh positif dan signifikan secara parsial terhadap kinerja karyawan. Komitmen kerja dan loyalitas berpengaruh signifikan secara simultan terhadap kinerja karyawan

METODE PENYAMPAIAN PESAN DAKWAH DENNIS LIM MELALUI MEDIA SOSIAL TIK-TOK

Di era sekarang ini menyampaikan pesan dakwah sangatlah mudah, salah satunya dengan menyebarkan video melalui TikTok atau media sosial lainnya, kita bisa berdakwah tanpa harus pergi ke berbagai lokasi untuk berdakwah dan tanpa harus terikat ruang dan waktu. Dakwah di media sosial Tik Tok merupakan dakwah yang efektif digunakan untuk kalangan milenial . Durasi maksimal tiga menit, membuat masyarakat semakin menarik dan mudah menerima pesan dakwah. Begitu banyak mubaligh Indonesia menggunakan media sosial Tik-Tok untuk menyampaikan pesan dakwahnya, salah satunya adalah Koh Dennis Liim. Cara berbagi Koh Dennis dengan mengikuti tren di TikTok, sambil tetap memberikan pesan positif. Sasaran yang diambil Ustadz Agam adalah mengikutsertakan kalangan muda dan orang tua. Penelitian ini menggunakan metode penelitian deskriptif kualitatif, dengan teori difusi inovasi. Fokus penelitian ini adalah untuk membahas aktivitas da'i melalui TikTok, terkait dengan pemikiran atau karya mereka, serta peran dan kontribusi sosial mereka di berbagai bidang atau kegiatan sosial di masyarakat. Metode yang digunakan Koh Dennis adalah metode ceramah. Dengan sifat komunikasi satu arah transparan (monolog), dan bisa juga dua arah (dialog) transparan. Yang dimaksud transparan adalah dilakukan tanpa tatap muka tetapi ada umpan balik. Sebagian besar materi yang dibawakan oleh Koh Dennis diambil dari peristiwa yang pernah dialaminya atau permasalahan yang up to dat

Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with prognosis of estrogen receptor-negative breast cancer after chemotherapy

Introduction: Tumor lymphocyte infiltration is associated with clinical response to chemotherapy in estrogen receptor (ER) negative breast cancer. To identify variants in immunosuppressive pathway genes associated with prognosis after adjuvant chemotherapy for ER-negative patients, we studied stage I-III invasive breast cancer patients of European ancestry, including 9,334 ER-positive (3,151 treated with chemotherapy) and 2,334 ER-negative patients (1,499 treated with chemotherapy). Methods: We pooled data from sixteen studies from the Breast Cancer Association Consortium (BCAC), and employed two independent studies for replications. Overall 3,610 single nucleotide polymorphisms (SNPs) in 133 genes were genotyped as part of the Collaborative Oncological Gene-environment Study, in which phenotype and clinical data were collected and harmonized. Multivariable Cox proportional hazard regression was used to assess genetic associations with overall survival (OS) and breast

Refined histopathological predictors of BRCA1 and BRCA2 mutation status: A large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia

Introduction: The distribution of histopathological features of invasive breast tumors in BRCA1 or BRCA2 germline mutation carriers differs from that of individuals with no known mutation. Histopathological features thus have utility for mutation prediction, including statistical modeling to assess pathogenicity of BRCA1 or BRCA2 variants of uncertain clinical significance. We analyzed large pathology datasets accrued by the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) and the Breast Cancer Association Consortium (BCAC) to reassess histopathological predictors of BRCA1 and BRCA2 mutation status, and provide robust likelihood ratio (LR) estimates for statistical modeling. Methods: Selection criteria for study/center inclusion were estrogen receptor (ER) status or grade data available for invasive breast cancer diagnosed younger than 70 years. The dataset included 4,477 BRCA1 mutation carriers, 2,565 BRCA2 mutation carriers, and 47,565 BCAC breast cancer cases. Country-stratified estimates of the

The future of work in shaping the employment inclusion of young adults with disabilities:a qualitative study

Purpose: The world of work is changing and creating challenges and opportunities for the employment inclusion of young people with disabilities. In this article, the perceptions held by young adults with disabilities regarding participation in the future of work are examined. Design/methodology/approach: One-on-one interviews were conducted with Canadian young adults (ages 18–36 years) living with a disability. Participants were asked about their thoughts regarding the impact of the changing nature of work on their labor market involvement and career aspirations. A thematic analysis was performed to identify and examine emergent salient themes. Findings: In total, 22 young adults were interviewed; over half held secure employment. Career aspirations and work-related decisions were primarily shaped by a participant's health needs. The future of work was seen as a more proximal determinant to employment. Digital technologies were expected to impact working conditions and create barriers and facilitators to employment. Participants who indicated being securely employed held positive expectations regarding the impact of digital technology on their work. Participants working precariously held negative appraisals regarding the impact of digital technologies on employment opportunities. The role of technological and soft skills was critical to participating in a labor market reliant on advanced technology. Participants reported barriers to developing job skills related to their disability and their work arrangements. Originality/value: This research highlights the importance of considering changes in the future of work, especially the digital transformation of the economy, in the design of initiatives which promote the employment inclusion of young adults with disabilities. Despite the significance of the changing nature of work, supporting health needs and encouraging access to secure work arrangements also remain paramount.</p

2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy

Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen receptor (ER)-negative patients treated with chemotherapy (279 events) from 14 European studies in a prior large-scale genotyping experiment, which is part of the Collaborative Oncological Gene-environment Study (COGS) initiative. We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events). Rs4458204-A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49-2.19); P for trend=1.90 × 10 â ̂'9). Such survival-associated variants can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities

Tracking the emergence of azithromycin resistance in multiple genotypes of typhoidal salmonella

The rising prevalence of antimicrobial resistance in Salmonella enterica serovars Typhi and Paratyphi A, causative agents of typhoid and paratyphoid, have led to fears of untreatable infections. Of specific concern is the emerging resistance against azithromycin, the only remaining oral drug to treat extensively drug resistant (XDR) typhoid. Since the first report of azithromycin resistance from Bangladesh in 2019, cases have been reported from Nepal, India, and Pakistan. The genetic basis of this resistance is a single point mutation in the efflux pump AcrB (R717Q/L). Here, we report 38 additional cases of azithromycin-resistant (AzmR) Salmonella Typhi and Paratyphi A isolated in Bangladesh between 2016 and 2018. Using genomic analysis of 56 AzmR isolates from South Asia with AcrB-R717Q/L, we confirm that this mutation has spontaneously emerged in different Salmonella Typhi and Paratyphi A geno-types. The largest cluster of AzmR Typhi belonged to genotype 4.3.1.1; Bayesian analysis predicts the mutation to have emerged sometime in 2010. A travel-related Typhi isolate with AcrB-R717Q belonging to 4.3.1.1 was isolated in the United Kingdom, increasing fears of global spread. For real-time detection of AcrB-R717Q/L, we developed an extraction-free, rapid, and low-cost mismatch amplification mutation assay (MAMA). Validation of MAMA using 113 AzmR and non-AzmR isolates yielded >98% specificity and sensitivity versus phenotypic and whole-genome sequencing assays currently used for azithromycin resistance detection

Optimization of boron dispersion on fibrous-silica-nickel catalyst for enhanced CO2 hydrogenation to methane

There are numerous reports regarding boron-containing catalysts for hydrogen-related reactions from CO2 including dry reforming of methane and methanation. Besides enhancing the productivity, boron also improved nickel activity and stability. However, the detailed mechanistic study, particularly in explaining the starring role of boron in the enhanced reactions, is still lacking. Thus, herein we loaded boron on fibrous-silica-nickel and investigated their physicochemical properties and mechanistic route by means of in-situ FTIR for enhanced CO2 methanation. It was found that the appropriate dispersion of boron surrounds the nickel particles is an important factor to improve the adsorption of CO2 before interacting with split hydrogen atom from the nickel sides to form intermediates which are subsequently dehydrated, and then serial hydrogenation gave the final product of methane. Boron also accelerated the methanation and restricted coke formation. A hybrid approach on optimization via a face-centered central composite design and a response surface methodology showed that reaction using H2/CO2 ratio of 6, GHSV of 10,500 mL g−1 h−1, at 500 °C gave the highest percentage of CH4 of 84.3%. To indicate the error, the predicted values were compared to the experimental values, yielding an accurately minimal error ranging from 0 to 11%. As a result, the empirical models generated for CO2 hydrogenation to methane were reasonably accurate, with all actual values for the confirmation runs fitting within the 94% prediction interval