Cutting a Convex Polyhedron Out of a Sphere

Given a convex polyhedron $P$ of $n$ vertices inside a sphere $Q$, we give an $O(n^3)$-time algorithm that cuts $P$ out of $Q$ by using guillotine cuts and has cutting cost $O((\log n)^2)$ times the optimal.Comment: 10 page

Service marketing overview of RFL export department

This internship report is submitted in a partial fulfillment of the requirements for the degree of Master of Business Administration, 2015.Cataloged from PDF version of Internship reportIncludes bibliographical references (page 34)Md. Ariful Islam Bappy,M. Business Administratio

Medications development for drug addiction and other neuropsychiatric disorders

Drug addiction and abuse especially opiate and psychostimulant abuse is a national and global crisis. IBNtxA (3-iodobenzoyl naltrexamine) is a novel mu opioid receptor (MOR) agonist, a naloxone derivative, structurally related to the classical MOR antagonist naltrexone. Recent studies suggest IBNtxA preferentially signals through truncated MOR splice variants, producing a unique pharmacological profile resulting in potent analgesia with reduced side effects. It has been found that M. vaccae has immunoregulatory effects that can prevent stress-induced exaggeration of neuroinflammation in the brain. The purpose of our pilot study is to develop medication for addiction and neuropsychiatric disorders. According to our purpose, we evaluated a range of IBNtxA doses to more fully assess its abuse liability and antiaddiction properties and the preimmunization effect of heat-killed M. vaccae on cocaine addiction. IBNtxA represents an intriguing lead compound for preclinical drug development specifically targeting MOR splice variants, potentially creating effective analgesics with reduced side effects. Furthermore, IBNtxA could have use as an adjunct therapy in agonist replacement strategies (e.g., methadone). M. vaccae might be helpful for cocaine relapse. Current collaborative efforts are aimed to find the total signaling pathways of IBNtxA and the effect of M. vaccae on cocaine self-administration, cocaine induced neuroinflammations and to keep finding medicine for neurological diseases

Study on baseline characteristics and lipid profile abnormalities among type 2 diabetic patients attending urban diabetic care hospital, Bangladesh

Background: Altered levels of serum glycated hemoglobin (HbA1c) and lipid profile are prevalent in patients having type 2 diabetic mellitus (T2DM). Aim of the study was to investigate the relationship between serum HbA1c and lipid profile in T2DM to predict diabetic dyslipidemia.Methods: A structured questionnaire was filled up by each study subject to collect data according to study protocol including age, gender, BMI, BP, residential status, socio-economic status, educational status, physical activity, dietary habit, smoking and duration of diabetes. We collected blood samples from 270 type-2 diabetes mellitus (T2DM) patients aged 30-65 years after overnight fasting (10-12 hours). Then blood samples collected from T2DM patients were used to measure serum levels of HbA1c, fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) were estimated by standard laboratory methods.Results: In this study, increased levels of fasting blood glucose (8.61 mmo/l), HbA1c (7.86%), TC (226.15 mg/dl), TG (193.34 mg/dl) and LDL (147.37 mg/dl), and decreased levels of HDL (40.36 mg/dl) were observed in T2DM patients. Moreover, the strong positive correlation of HbA1c levels with FBG, TC, TG, and LDL levels were found in this study. Besides, a very strong and significant negative correlation (R2=0.1822) between the serum levels of HbA1c and HDL were noted in this study.Conclusions: This study revealed a strong correlation between dyslipidemia and serum levels of HbA1c in T2DM patients

Crustal Structures of Diebold Knoll and Adjacent Juan De Fuca Oceanic Crust from Integration of Seismic, Gravity and Magnetic Data

Cascadia Subduction Zone (CSZ) has a long history of devastating earthquakes as the Juan de Fuca plate subducts beneath North America, where an imminent megathrust earthquake is expected. Compared to other subduction zones, CSZ exhibits unusually low seismic activity, particularly in the central region with respect to relatively high seismicity zones to the north and south. Some researchers attribute this behavior to subducted seamounts, although their impact on seismicity remains poorly understood and highly debated in the literature. Examining subducted seamounts is challenging due to complexity of the overburden strata. That is why this study focuses on an isolated not-yet-subducted intraplate seamount known as the Diebold Knoll, located approximately 60 km west of the deformation front. Seismic reflection, gravity, and magnetic data were acquired over that seamount during the cruise RR1718. The first objective of this research was to determine heterogeneities in physical properties of oceanic crust resulted from addition of the seamount by integrated geophysical analysis along two intersecting profiles. The second objective was to reveal the tectonic history of the Diebold Knoll by combining magnetic polarity reversals with cross-cutting relationship analysis of seismic structures and constrained by the nearby ocean drilling sites. These models revealed that Diebold Knoll does not require complete isostatic compensation. Instead, a flat Moho or a less than 1 km thick root is sufficient to satisfy gravity data; both of these Moho geometries are observed in the study area. To achieve a better fit with observed gravity and magnetic anomalies, lower density and magnetic susceptibility values within the top portion of the seamount are required, which are attributed to faulting and hydration. This finding is also in agreement with a recent study that analyzed seismic velocity variations within seamounts. Furthermore, the negative magnetic anomaly of the seamount and the cross-cutting relationships between sedimentary layers and the seamount body indicated that Diebold Knoll is a very young feature formed approximately 0.8-1.8 Ma. Advisor: Irina Filin

Towards sustainable ICT procurement : impacting data based decision-making in B2B green ICT adoption

The rapid growth of the Information and Communication Technology (ICT) sector, with its expanding economic output and escalating environmental and social impacts, including significant energy usage and waste production, necessitates a shift towards sustainable procurement practices within the business-to-business (B2B) context. This study addresses this challenge by developing and validating the Sustainable ICT Device Acquisition (SIDA) framework and tool, integrating a Supplier Selection Questionnaire (SSQ) and Sustainability Guidelines offers a structured approach for integrating sustainability criteria into ICT procurement decisions. Through the utilization of design science research methodology and a mixed-methods approach, which includes a systematic literature review, interviews, and a survey, this study identifies the key barriers and enablers to sustainable ICT procurement within the European landscape. An application operationalizing the SIDA framework was proposed including features such as a sustainability assessment dashboard, supplier evaluation module (integrating the SSQ), and total cost of ownership (TCO) calculator, empower decision-makers with comprehensive information and data-driven insights. Workshops on the proposed tool’s design and functionality with industry practitioners and academic experts indicate its potential to raise awareness, streamline supplier evaluation, and enhance decision-making in alignment with sustainability goals. It is firmly believed that this research contributes to the field by providing a theoretically grounded and empirically validated framework and tool, promoting responsible ICT procurement decisions that benefit both businesses and the environment