L-Lysine Imprinted Nanoparticles for Antibody Biorecognition

The aim of this study was to prepare L-lysine-imprinted poly(HEMA-MAAsp) nanoparticles which can be used for the adsorption of IgG from aqueous solutions. L-lysine was complexed with MAAsp and Llysine- imprinted poly(HEMA-MAAsp) nanoparticles were synthesized by miniemulsion polymerization. Also, non-imprinted nanoparticles were synthesized without L-lysine for control purpose. L-lysine-imprinted poly(HEMA-MAAsp) nanoparticles were characterized by means of elemental analysis, Fourier transform infrared spectroscopy (FTIR) and transmission electron microscopy (TEM). When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3500

EXPECTATIONS OF PARENTS WHO ARE SENDING THEIR CHILDREN TO SWIMMING SPORTS

This study was designed to investigate the causes of families' sending their children to swimming summer schools. The working group constitutes the parents who send their children to the summer school swimming schools in Kahramanmaras. A total of 203 people, 155 female and 48 male, participated in the research. In order to determine the reasons for sending the children to the swimming schools, the scale developed by Meral (2010) was utilized. While the findings obtained in the study were evaluated, SPSS 22.0 program was used for statistical analysis. When the study data were evaluated, with Percentage and Frequency, ANOVA and Tukey multiple comparison tests were used for t-test for two independent groups, and comparison of more independent groups. As a result of the study: it is seen that the parents and children are more likely to be concerned about the health of the children, the social relations and the development of the sense of responsibility, the higher the anxiety levels of the men compared to the women, and also there is no statistically significant difference between the education levels and the occupations and expectations.  Article visualizations

Evaluation of controlled hydroxychloroquine releasing performance from calcium-alginate beads

The aim of this study was to develop an effective controlled drug delivery system based on alginate beads for the treatment of autoimmune diseases such as Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE). The present study describes the drug delivery systems to control the effective uses of hydroxychloroquine (HCQ) by Ca-alginate beads. The characterization techniques were employed to evaluate the physicochemical properties as scanning electron microscopy (SEM), swelling test (S), hydrolytic degradation (weight loss, WL) and Fourier transform infrared-attenuated total reflection (FTIR-ATR). The release studies from alginate beads prepared in various drug dose were carried out in the aqueous solutions at different pH (5–8) and temperature (4-37oC). The approximately half-amount of HCQ in HCQ-AB3 was released in 12 h and about 84.38% was released within 8 days. Kinetic model, Korsmeyer-Peppas was applied to model the HCQ release kinetic of alginate beads, which corresponded to non-Fickian transport mechanism

Mikroplastikler, Çevre-İnsan Sağlığı Üzerine Etkileri Ve Analiz Yöntemleri

Plastikler, günlük yaşantımızda birçok alanda kullanılmaktadır. İnsanlar şimdiye kadar 9 milyar tonun üzerinde plastik üretmişlerdir. 2050 yılına kadar neredeyse 38 milyar ton plastik üretilecek ve bunun 13 milyar tonu atık olacaktır. Atık plastikler zamanla bozunarak mikroplastikleri (ikincil mikroplastikleri) oluşturacak, ayrıca kozmetik, ilaç gibi sektörlerde kullanılmak üzere kasıtlı üretilen mikroplastiklerde (birincil mikroplastikler) çevreye salınmış olacaktır. Mikroplastiklerin dağılımı 1 metreküpte 1 milyondan fazla parçada bulunabilmekte 100 metreküpte 1 parçadan daha az da bulunabilmektedir. Çevre mikroplastik birikimine ve taşınımına katkıda bulunmakta, ayrıca mikroplastikler absorpsiyon nedeniyle ortamda bulunan mikro kirleticileri ve bazı ağır metalleri bünyesinde tutarak yayılmasına neden olmaktadır. Bu da mikroplastiklerin katlanarak tehlike oluşturduğu anlamına gelmektedir. Mikroplastikler, hem suda yaşayan canlılar için hem de insanlar için tehdit oluşturduklarından dolayı gittikçe artan endişelere neden olmaktadır. Mikroplastiklerin çeşitli yollarla insan bünyesine alınmasının, insan sağlığı üzerinde oluşturabileceği olumsuz etkiler hakkında bilgiler çok sınırlıdır. Dolayısıyla insanların nedenli bir tehlike ile karşı karşıya kaldığını kestirmek zor olaktadır. Mikroplastiklerin insan ve çevre sağlığı üzerindeki risklerinin acil olarak araştırılmaya ihtiyacı vardır. Bu makalenin amacı, mikroplastiklerin, çevre ve insan sağlığına olan potansiyel etkilerini, analiz yöntemlerini incelemektir

Gaziantep Şehrinde Kongre Turizminin Mevcut Durumu ve Geliştirilmesine Yönelik Bir Saha Araştırması

Bu çalışmada, Gaziantep‟te faaliyet gösteren turizm işletmeleri ile turizmle ilgili kamu kurumlarında çalışan personel ve yöneticilerin, Gaziantep kongre turizmine yönelik bakış açıları, Gaziantep‟in kongre turizmine yönelik  sorunları  ve  çözüm  önerilerine yönelik  görüşlerinin  tespit  edilmesi  amaçlanmaktadır.  Bu  amacın gerçekleştirilebilmesi için geliştirilen anket formu, 2016 yılının Nisan ve Mayıs aylarında Gaziantep şehrinde ongre turizmine hizmet sunan turizm işletmeleri ile turizmle ilgili kamu kurumlarında çalışan personel ve yöneticilerden oluşan 269 katılımcıya uygulanmıştır. Yapılan araştırmanın sonucunda katılımcıların, Gaziantep kongre turizminin gelişmesinin şehrin markalaşması ve ekonomisi üzerinde olumlu etki oluşturacağı görüşüne sahip  olduğu tespit  edilmiştir.  Ayrıca  Gaziantep‟te  kongre  turizmine  yönelik  tanıtım  ve  pazarlama faaliyetlerinde, alt ve üstyapı imkânlarında yetersizlikler olduğu, bu alanda görev alması gereken uzman personel konusunda eksiklikler olduğu konusunda katılımcıların görüş birliği içerisinde oldukları da tespit edilmiştir. Yine Gaziantep‟in kongre turizm alanında atacağı stratejik adımlar şehrin ekonomisine, markalaşmasına ve turizmden  elde  edeceği  geliri  arttırmasına katkı  sağlayacağı,  yapılan  bu  araştırmada  ortaya  konulan  diğer bulgular olmuştur

Fracture risk assessment in metabolic syndrome in terms of secondary osteoporosis potential. A narrative review

Osteoporosis is a major global public health problem with the associated bone fractures contributing significantly to both morbidity and mortality. In many countries, osteoporotic fractures will affect one in three women and one in five men over the age of 50. Similarly, diabetes, obesity, and metabolic syndrome (MetS) are among the leading public health problems due to their worldwide prevalence and burden on health budgets. Although seemingly disparate, metabolic disorders are known to affect bone health, and the interaction between fat and bone tissue is increasingly well understood. For example, it is now well established that diabetes mellitus (both type 1 and 2) is associated with fracture risk. In this narrative review, we focus on the potential link between MetS and bone health as expressed by bone mineral density and fracture risk. This narrative review demonstrates the association of MetS and its components with increased fracture risk, and also highlights the need for fracture risk assessment in patients with obesity and MetS

The presence of promatrix metalloproteinase-3 and its relation with different categories of coal workers' pneumoconiosis.

Extracellular matrix formation (ECM) and remodeling are critical events related to the pathogenesis of pulmonary fibrosis. Matrix metalloproteinases play an essential role in degrading and remodeling the ECM. In this study, we tried to show the presence and correlation of promatrix metalloproteinase-3 (proMMP-3) (the inactive form of metalloproteinase-3) levels in coal workers' pneumoconiosis (CWP) with different categories. The study population consisted of 44 coal miners with CWP (pos CWP). Coal miners without CWP (neg CWP, n = 24) and non-underground personnel (controls, n = 17) were taken as controls. All coal miners were stable and had no systemic infection or disease. Standard posterio-anterior chest radiographs and pulmonary function tests were performed to exclude any diseases other than CWP. Serum proMMP-3 was analysed using the sandwich enzyme-linked immunosorbent assay according to the manufacturer's instructions (The Binding Site, Birmingham, UK). Mean proMMP-3 values of the all three groups were compared and a significant statistical difference obtained (p < 0.001). In addition, a statistically significant difference was found between categories of the disease and proMMP-3 values (p < 0.05). The effects of age, exposure duration and cigarette smoking on proMMP-3 values in coal miners with CWP were investigated. There were no correlations between age, smoking and proMMP-3 values. However, a positive correlation was found between exposure duration and proMMP-3 values (r = 0.447, p = 0.008). In conclusion, proMMP-3 (prostromelysin 1) may play an essential role in degrading and remodeling the ECM in workers with pneumoconiosis. ProMMP-3 may also reflect the stage of pneumoconiosis disease

Characterizations for the fractional maximal operators on Carleson curves in local generalized Morrey spaces

In this paper we study the fractional maximal operator M-alpha in the local generalized Morrey space LMp,phi{to}(Gamma) and the generalized Morrey space M-p,M-phi(Gamma) defined on Carleson curves Gamma, respectively. For the operator M-alpha we shall give a characterization the strong and weak Spanne-Guliyev type boundedness on LMp,phi{to} (Gamma) and the strong and weak Adams-Guliyev type boundedness on M-p,M-phi(Gamma)

Effects of Combined Aerobic and Strength Training on Aerobic Capacity and Body Composition

The purpose of this study was to analyse the effects of combined aerobic and strength training in circuit training on body fat ratio. The universe of this study was selected as 32 male participants who continue their training and do fitness for health. Participants were divided into 2 groups: aerobic group (16 people) and combined group (16 people). This study was applied for 8 weeks, 3 days per week, and 1 hour per day. Participants were informed about how the tests will be conducted. An aerobic capacity test, body fat percentage, body mass index, and waist-hip ratio were among the applied tests and measurements. Data were analysed with SPSS 21 package program. Average and standard deviation of obtained data were calculated. Results showed that results of aerobic and combined trainings were similarly, and both aerobic and combined training positively affected body weight, body mass index, body fat percentage, and aerobic capacity values. Additionally, it can be stated that aerobic exercises directly affected waist-hip ratio compared to combined exercises, and combined training was more efficient for waist-hip ratio

Anti-acetylcholinesterase, antidiabetic, anti-inflammatory, antityrosinase and antixanthine oxidase activities of Moroccan propolis

Biological properties of Moroccan propolis have been scarcely studied. In the present work, the total phenols and flavonoids from 21 samples of propolis collected in different places of Morocco or 3 supplied in the market were determined, as well as the invitro capacity for inhibiting the activities of acetylcholinesterase, -glucosidase, -amylase, lipoxygenase, tyrosinase, xanthine oxidase and hyaluronidase. The results showed that samples 1 (region Fez-Boulemane, Sefrou city) (IC50=0.065, 0.006, 0.020, 0.050, 0.014mgmL(-1)) and 23 (marketed) (IC50=0.018, 0.002, 0.046, 0.037, 0.008mgmL(-1)) had the best invitro capacity for inhibiting the -amylase, -glucosidase, lipoxygenase, tyrosinase and xanthine oxidase activities, respectively. A negative correlation between IC50 values and concentration of phenols, flavones and flavanones was found. These activities corresponded to the generally higher amounts of phenols and flavonoids. In the same region, propolis samples have dissimilar phenol content and enzyme inhibitory activities