Thematic Report Three - Asylum, Security and Extremism

This is the final of three Thematic Reports published as part of a CREST-funded project carried out by a team of researchers at City, University of London, and Cranfield University at the Defence Academy of the United Kingdom. With the objective of better understanding Tamil diaspora communities’ attitudes and engagement in the Sri Lankan civil conflict (1983-2009) and its aftermath, the project explores diaspora and refugee communities’ relationship with the changing socio-political environment in the homeland, exploring what shapes and influences processes of radicalisation or moderation among these communities. It recognises that the socio-political circumstances in which these processes develop are often crucial to understanding why a community or individuals within that community abroad act in a certain way; this includes analysis of different scales and levels of engagement, both in home and host countries, as well as different ‘areas’ of engagement, which can include social, economic and political interactions. The three thematic reports produced as part of this project cumulatively build a comprehensive picture of the state of knowledge on political action among diaspora, refugee and asylum populations. The theoretically-informed, literature- and evidence-grounded conclusions arising from these three thematic reports are therefore of relevance beyond the case of Sri Lanka. Thematic Report One discussed how four analytical concepts, diaspora, transnationalism, cosmopolitanism, and translocalism, have come to frame the academic discussion of overseas politics and the potential of these concepts to shed light on the relationship between mobility and political action. Thematic Report Two complements the previous report’s broad conceptual discussion by specifically focusing on an analysis of the context and drivers of political action among diaspora and refugee populations, and engaging with the term ‘refugee politics’. The current paper – the final Thematic Report – analyses the growing ‘securitisation’ of refugees and other forcibly displaced populations and calls for greater consideration of structural vulnerabilities in the forced migration and displacement cycle that increase the risk of radicalisation, extremism and related political behaviours

Thematic Report One - Understanding Transnational Diaspora Politics: A Conceptual Discussion

This is the first of three CREST-funded Thematic Reports published by a team of researchers at City, University of London, and Cranfield University at the Defence Academy of the United Kingdom examining political action among diaspora populations. The purpose of the report is to explore the theoretical and conceptual basis underpinning academic debates on engagement in the politics of conflict and post-conflict by communities living overseas. The research team is interested specifically in the Sri Lankan civil conflict between 1983 and 2009 and its aftermath, and understanding the attitudes towards and involvement in that conflict on the part of Tamil diaspora communities. The CREST project is exploring diaspora communities’ relationship with the changing socio-political environment in the homeland and how this influences processes of radicalisation or moderation. It recognises that the socio-political circumstances in which these processes develop are often crucial towards understanding why a community or individuals within that community abroad act in a certain way; this includes analysis of different scales and levels of engagement, both in home countries and in host countries, as well as different ‘areas’ of engagement, which can range from social to economic to political interactions. The following review is not specific to the Sri Lankan situation; it is rather concerned with how four concepts, diaspora, transnationalism, cosmopolitanism, and translocalism, have come to frame the academic discussion of diaspora or more broadly overseas politics and the potential of the concepts to shed light on the relationship between mobility and political action. It considers the extent to which these concepts are helpful in identifying the rationale behind specific methods of political participation offering critical reflections on the analytical and normative usefulness of these terms

Thematic Report Two - The Engagement of Refugees in Transnational Politics: Lessons from the Migration, Diaspora and Refugee Studies Literature

This is the second of three CREST-funded Thematic Reports published by a team of researchers at City, University of London, and Cranfield University at the Defence Academy of the United Kingdom, that cumulatively build a comprehensive picture of the state of knowledge on political action among diaspora and refugee populations. The research team is specifically interested in applying the theoretically-informed, literature and evidence grounded conclusions arising from these reports to understand the attitudes towards and involvement in the Sri Lankan civil conflict (1983-2009) and its aftermath by Tamil diaspora communities, but with a broader application. The CREST project is exploring diaspora and refugee communities’ relationship with the changing socio-political environment in the homeland and how this influences processes of radicalisation or moderation. It recognises that the socio-political circumstances in which these processes develop are often crucial to understanding why a community or individuals within that community abroad act in a certain way; this includes analysis of different scales and levels of engagement, both in home countries and in host countries, as well as different ‘areas’ of engagement, which can include social, economic and political interactions. Thematic Report One discussed how four analytical concepts, diaspora, transnationalism, cosmopolitanism, and translocalism, have come to frame the academic discussion of overseas politics and the potential of the concepts to shed light on the relationship between mobility and political action. The current paper – Thematic Report Two – complements the previous report’s broad conceptual discussion by specifically focusing on an analysis of the context and drivers of political action among diaspora and refugee populations, and engaging with the term ‘refugee politics’. It considers if the available diaspora and migration literature sheds light on whether the processes and dynamics of forced migration are likely to generate identifiable forms of political engagement

An agent-based system for maritime search and rescue operations.

Maritime search and rescue operations are critical missions involving personnel, boats, helicopter, aircrafts in a struggle against time often worsened by adversary sea and weather conditions. In such a context, telecommunication and in- formation systems may play a crucial role sometimes concurring to successfully accomplish the mission. In this paper we present an application able to localize the vessel who has launched a rescue request and to plan the most effective path for rescue assets. The application has been realised as a distributed and open multi-agent system deployed on rescue vehicles as well as on a land maritime stations of the Italian Coast Guard. The system is going to be tested in real scenarios by the Coast Guard

Regulation of Kir4.1 expression in astrocytes and astrocytic tumors: a role for interleukin-1 beta

<p>Abstract</p> <p>Objective</p> <p>Decreased expression of inwardly rectifying potassium (Kir) channels in astrocytes and glioma cells may contribute to impaired K⁺ buffering and increased propensity for seizures. Here, we evaluated the potential effect of inflammatory molecules, such as interleukin-1β (IL-1β) on Kir4.1 mRNA and protein expression.</p> <p>Methods</p> <p>We investigated Kir4.1 (Kcnj10) and IL-1β mRNA expression in the temporal cortex in a rat model of temporal lobe epilepsy 24 h and 1 week after induction of status epilepticus (SE), using real-time PCR and western blot analysis. The U373 glioblastoma cell line and human fetal astrocytes were used to study the regulation of Kir4.1 expression in response to pro-inflammatory cytokines. Expression of Kir4.1 protein was also evaluated by means of immunohistochemistry in surgical specimens of patients with astrocytic tumors (<it>n</it> = 64), comparing the expression in tumor patients with (<it>n</it> = 38) and without epilepsy (<it>n</it> = 26).</p> <p>Results</p> <p>Twenty-four hours after onset of SE, Kir4.1 mRNA and protein were significantly down-regulated in temporal cortex of epileptic rats. This decrease in expression was followed by a return to control level at 1 week after SE. The transient downregulation of Kir4.1 corresponded to the time of prominent upregulation of IL-1β mRNA. Expression of Kir4.1 mRNA and protein in glial cells in culture was downregulated after exposure to IL-1β. Evaluation of Kir4.1 in tumor specimens showed a significantly lower Kir4.1 expression in the specimens of patients with epilepsy compared to patients without epilepsy. This paralleled the increased presence of activated microglial cells, as well as the increased expression of IL-1β and the cytoplasmic translocation of high mobility group box 1 (HMGB1).</p> <p>Conclusions</p> <p>Taken together, these findings indicate that alterations in expression of Kir4.1 occurring in epilepsy-associated lesions are possibly influenced by the local inflammatory environment and in particular by the inflammatory cytokine IL-1β.</p

Spatio-temporal behaviour of the deep chlorophyll maximum in Mediterranean Sea: Development of a stochastic model for picophytoplankton dynamics

In this paper, by using a stochastic reaction-diffusion-taxis model, we analyze the picophytoplankton dynamics in the basin of the Mediterranean Sea, characterized by poorly mixed waters. The model includes intraspecific competition of picophytoplankton for light and nutrients. The multiplicative noise sources present in the model account for random fluctuations of environmental variables. Phytoplankton distributions obtained from the model show a good agreement with experimental data sampled in two different sites of the Sicily Channel. The results could be extended to analyze data collected in different sites of the Mediterranean Sea and to devise predictive models for phytoplankton dynamics in oligotrophic waters

Neuroinflammatory targets and treatments for epilepsy validated in experimental models

A large body of evidence that has accumulated over the past decade strongly supports the role of inflammation in the pathophysiology of human epilepsy. Specific inflammatory molecules and pathways have been identified that influence various pathologic outcomes in different experimental models of epilepsy. Most importantly, the same inflammatory pathways have also been found in surgically resected brain tissue from patients with treatment-resistant epilepsy. New antiseizure therapies may be derived from these novel potential targets. An essential and crucial question is whether targeting these molecules and pathways may result in anti-ictogenesis, antiepileptogenesis, and/or disease-modification effects. Therefore, preclinical testing in models mimicking relevant aspects of epileptogenesis is needed to guide integrated experimental and clinical trial designs. We discuss the most recent preclinical proof-of-concept studies validating a number of therapeutic approaches against inflammatory mechanisms in animal models that could represent novel avenues for drug development in epilepsy. Finally, we suggest future directions to accelerate preclinical to clinical translation of these recent discoveries

Atherosclerosis in the circle of Willis: Spatial differences in composition and in distribution of plaques

AbstractBackground and aimsIntracranial atherosclerosis is one of the main causes of ischemic stroke. However, the characteristics of intracranial arteries and atherosclerosis have rarely been studied. Therefore, we systematically investigated atherosclerotic changes in all arteries of the Circle of Willis (CoW).MethodsSixty-seven CoWs obtained at autopsy from randomly chosen hospital patients (mean age, 67.3 ± 12.5 years), of which a total of 1220 segments were collected from 22 sites. Atherosclerotic plaques were classified according to the revised American Heart Association classification and were related to local vessel characteristics, such as the presence of an external and internal elastic lamina and the elastic fibre density of the media.Results181 out of the 1220 segments had advanced plaques (15%), which were mainly observed in large arteries such as the internal carotid, middle cerebral, basilar and vertebral artery. Only 11 out of 1220 segments (1%) showed complicated plaques (p < 0.001). Six of these were intraplaque hemorrhages (IPH) and observed only in patients who had cardiovascular-related events (p = 0.015). The frequency of characteristics such as the external elastic lamina and a high elastin fibre density in the media was most often associated with the vertebral artery. Only 3% (n = 33) of the CoW arteries contained calcification (p < 0.001), which were mostly observed in the vertebral artery (n = 13, 12%).ConclusionsAdvanced atherosclerotic plaques in the CoW are relatively scarce and mainly located in the 4 large arteries, and mostly characterized by an early and stable phenotype, a low calcific burden, and a low frequency of IPH