An electrochemical and surface analytical study of the formation of nanoporous oxides on niobium

In the present paper, the anodization of Nb in mixed sulphate + fluoride electrolytes resulting in the formation of a nanoporous oxide film has been studied. Chronoamperometry and electrochemical impedance spectroscopy have been employed to characterise in situ the kinetics of the oxidation process. In addition, the evolution of the layer structure and morphology has been followed by ex situ scanning electron microscopy. Particularly, local electrochemical impedance spectroscopy has been used to discern between the mesoscopic 2D and 3D distributions of time constants at the electrode surface. The similarity between local and global impedance spectra during anodic oxidation of Nb demonstrates the presence of an inherent 3D distribution of the high-frequency time constant, which is interpreted as in-depth variation of the steady state conductivity of the passive film. The experimental and calculational results are discussed in relation to the micro- and nanoscopic structure of the formed oxide

Reliability of a Novel Model for Drug Release from 2D HPMC-Matrices

A novel model of drug release from 2D-HPMC matrices is considered. Detailed mathematical description of matrix swelling and the effect of the initial drug loading are introduced. A numerical approach to solution of the posed nonlinear 2D problem is used on the basis of finite element domain approximation and time difference method. The reliability of the model is investigated in two steps: numerical evaluation of the water uptake parameters; evaluation of drug release parameters under available experimental data. The proposed numerical procedure for fitting the model is validated performing different numerical examples of drug release in two cases (with and without taking into account initial drug loading). The goodness of fit evaluated by the coefficient of determination is presented to be very good with few exceptions. The obtained results show better model fitting when accounting the effect of initial drug loading (especially for larger values)

Numerical Modelling of Drug Release from 2D HPMC-Matrices

The article considers numerical modelling of drug release from HPMC-matrices assuming the main controlling processes are diffusion of water and drug and swelling of the matrix. A detailed mathematical description of matrix swelling, connected with the free boundary conditions of the arisen model problem, is introduced. A numerical approach to solution of the posed nonlinear 2D problem is developed on the basis of finite element domain approximation and time difference method. It is implemented in noncommercial software which is used for numerical simulation of fractional drug release under various shapes and sizes of the tablets. This investigation of the effect of aspect ratio (radius/height) and sizes of HPMC tablets on drug release is an inexpensive and effective tool to modify the release kinetics. The proposed numerical approach enables further generalization of the model and performing more profound investigations of the effect of the initial drug loading, matrix erosion and type of release medium

Inferring the stiffness of unfamiliar objects from optical, shape, and motion cues

Abstract Visually inferring the stiffness of objects is important for many tasks but is challenging because, unlike optical properties (e.g., gloss), mechanical properties do not directly affect image values. Stiffness must be inferred either (a) by recognizing materials and recalling their properties (associative approach) or (b) from shape and motion cues when the material is deformed (estimation approach). Here, we investigated interactions between these two inference types. Participants viewed renderings of unfamiliar shapes with 28 materials (e.g., nickel, wax, cork). In Experiment 1, they viewed nondeformed, static versions of the objects and rated 11 material attributes (e.g., soft, fragile, heavy). The results confirm that the optical materials elicited a wide range of apparent properties. In Experiment 2, using a blue plastic material with intermediate apparent softness, the objects were subjected to physical simulations of 12 shape-transforming processes (e.g., twisting, crushing, stretching). Participants rated softness and extent of deformation. Both correlated with the physical magnitude of deformation. Experiment 3 combined variations in optical cues with shape cues. We find that optical cues completely dominate. Experiment 4 included the entire motion sequence of the deformation, yielding significant contributions of optical as well as motion cues. Our findings suggest participants integrate shape, motion, and optical cues to infer stiffness, with optical cues playing a major role for our range of stimuli

Monolithic Controlled Delivery Systems: Part I. Basic Characteristics and Mechanisms

The article considers contemporary systems for controlled delivery of active agents, such as drugs, agricultural chemicals, pollutants and additives in the environment. A useful classification of the available controlled release systems (CRS) is proposed according to the type of control (passive, active or self-preprogrammed) and according to the main controlling mechanism (diffusion, swelling, dissolution or erosion). Special attention is given to some of the most used CRS - polymer monoliths. The structural and physical-chemical characteristics of CRS as well as the basic approaches to their production are examined. The basic mechanisms of controlled agent release are reviewed in detail and factors influencing the release kinetics are classified according to their importance. The present study can be helpful for understanding and applying the available mathematical models and for developing more comprehensive ones intended for design of new controlled delivery systems

The Impact of Complexity, Rate of Change and Information Availability on the Production Planning and Control Structure

The organizational theory literature argues that the more uncertain the environment, the more likely the firm’s operational decision structure is decentralized. However, it remains unclear which uncertainty dimensions (i.e. complexity, rate of change and lack of information) impacts the production planning and control structure the most given today’s turbulent manufacturing environments. Based on 206 responses from medium sized Dutch discrete parts manufacturing firms, this study retests the impact of these uncertainty dimensions. This study indicates that each dimension of uncertainty affects the production planning and control structure in a different way. In general, complexity, rate of change and lack of information result in a decentralization of the operational planning and control decision structure, but at the same time a centralization of the customer-order processing decision structure.empirical research method;production planning and control structure;structural equations model;uncertainty

Role of therapeutic drug monitoring in pulmonary infections : use and potential for expanded use of dried blood spot samples

Respiratory tract infections are among the most common infections in men. We reviewed literature to document their pharmacological treatments, and the extent to which therapeutic drug monitoring (TDM) is needed during treatment. We subsequently examined potential use of dried blood spots as sample procedure for TDM. TDM was found to be an important component of clinical care for many (but not all) pulmonary infections. For gentamicin, linezolid, voriconazole and posaconazole dried blood spot methods and their use in TDM were already evident in literature. For glycopeptides, beta-lactam antibiotics and fluoroquinolones it was determined that development of a dried blood spot (DBS) method could be useful. This review identifies specific antibiotics for which development of DBS methods could support the optimization of treatment of pulmonary infections