RELEVANSI PEMIKIRAN IR. SOEKARNO TERHADAP PENDIDIKAN ISLAM (Studi Peran dan Kedudukan Perempuan dalam Buku Sarinah Karya Ir. Soekarno)

Realitas kehidupan masyarakat Indonesia yang dikenal dengan sifat patriarki, yaitu praktik sosial yang memberikan kewenangan kepada laki-laki untuk menekan dan mengeksploitasi perempuan yang melahirkan norma sosial, hukum serta moral yang mengunggulkan kaum laki-laki. Sehingga stigma masyarakat tentang perempuan berkeyakinan bahwa perempuan adalah bagian belakang atau konco wingking, ungkapan Jawa ini menimbulkan kurangnya masyarakat dan laki-laki memahami peran dan kedudukan perempuan. Seperti yang diungkapkan Soekarno bahwa perempuan adalah persoalan besar yang perlu dipecahkan karena perempuan bagian dari suatu bangsa, tanpa peran perempuan bangsa ini tidak akan maju. Oleh karena itu, harus pemahaman dari perempuan, laki-laki, masyarakat tentang peran dan kedudukan perempuan dalam Islam. Pemikiran Ir. Soekarno tentang peran dan kedudukan perempuan dalam buku Sarinah sesuai dengan Pendidikan Islam yaitu peran perempuan ada dalam keluarga, keagamaan, sosial, politik, ekonomi serta kedudukan yang diunggulkan dari pada laki-laki sesuai dengan Islam. Relevansi pemikiran Ir. Soekarno dalam buku Sarinah pada peran dan kedudukan perempuan masa sekarang masih ada korelasi antara adat istiadat masa dahulu, sehingga keseimbangan dapat diperoleh sesuai berkembangnya zaman. Kata Kunci:Pendidikan Agama Islam, Peran dan kedudukan, pemikiran Soekarno

RELEVANSI PEMIKIRAN IR. SOEKARNO TERHADAP PENDIDIKAN ISLAM (Studi Peran dan Kedudukan Perempuan dalam Buku Sarinah Karya Ir. Soekarno)

Realitas kehidupan masyarakat Indonesia yang dikenal dengan sifat patriarki, yaitu praktik sosial yang memberikan kewenangan kepada laki-laki untuk menekan dan mengeksploitasi perempuan yang melahirkan norma sosial, hukum serta moral yang mengunggulkan kaum laki-laki. Sehingga stigma masyarakat tentang perempuan berkeyakinan bahwa perempuan adalah bagian belakang atau konco wingking, ungkapan Jawa ini menimbulkan kurangnya masyarakat dan laki-laki memahami peran dan kedudukan perempuan. Seperti yang diungkapkan Soekarno bahwa perempuan adalah persoalan besar yang perlu dipecahkan karena perempuan bagian dari suatu bangsa, tanpa peran perempuan bangsa ini tidak akan maju. Oleh karena itu, harus pemahaman dari perempuan, laki-laki, masyarakat tentang peran dan kedudukan perempuan dalam Islam. Pemikiran Ir. Soekarno tentang peran dan kedudukan perempuan dalam buku Sarinah sesuai dengan Pendidikan Islam yaitu peran perempuan ada dalam keluarga, keagamaan, sosial, politik, ekonomi serta kedudukan yang diunggulkan dari pada laki-laki sesuai dengan Islam. Relevansi pemikiran Ir. Soekarno dalam buku Sarinah pada peran dan kedudukan perempuan masa sekarang masih ada korelasi antara adat istiadat masa dahulu, sehingga keseimbangan dapat diperoleh sesuai berkembangnya zaman.   Kata Kunci:Pendidikan Agama Islam, Peran dan kedudukan, pemikiran Soekarno

TGF-beta 1 induces human alveolar epithelial to mesenchymal cell transition (EMT)

Background: Fibroblastic foci are characteristic features in lung parenchyma of patients with idiopathic pulmonary fibrosis (IPF). They comprise aggregates of mesenchymal cells which underlie sites of unresolved epithelial injury and are associated with progression of fibrosis. However, the cellular origins of these mesenchymal phenotypes remain unclear. We examined whether the potent fibrogenic cytokine TGF-β1 could induce epithelial mesenchymal transition (EMT) in the human alveolar epithelial cell line, A549, and investigated the signaling pathway of TGF-β1-mediated EMT. Methods: A549 cells were examined for evidence of EMT after treatment with TGF-β1. EMT was assessed by: morphology under phase-contrast microscopy; Western analysis of cell lysates for expression of mesenchymal phenotypic markers including fibronectin EDA (Fn-EDA), and expression of epithelial phenotypic markers including E-cadherin (E-cad). Markers of fibrogenesis, including collagens and connective tissue growth factor (CTGF) were also evaluated by measuring mRNA level using RT-PCR, and protein by immunofluorescence or Western blotting. Signaling pathways for EMT were characterized by Western analysis of cell lysates using monoclonal antibodies to detect phosphorylated Erk1/2 and Smad2 after TGF-β1 treatment in the presence or absence of MEK inhibitors. The role of Smad2 in TGF-β1-mediated EMT was investigated using siRNA. Results: The data showed that TGF-β1, but not TNF-α or IL-1β, induced A549 cells with an alveolar epithelial type II cell phenotype to undergo EMT in a time-and concentration-dependent manner. The process of EMT was accompanied by morphological alteration and expression of the fibroblast phenotypic markers Fn-EDA and vimentin, concomitant with a downregulation of the epithelial phenotype marker E-cad. Furthermore, cells that had undergone EMT showed enhanced expression of markers of fibrogenesis including collagens type I and III and CTGF. MMP-2 expression was also evidenced. TGF-β1-induced EMT occurred through phosphorylation of Smad2 and was inhibited by Smad2 gene silencing; MEK inhibitors failed to attenuate either EMT-associated Smad2 phosphorylation or the observed phenotypic changes. Conclusion: Our study shows that TGF-β1 induces A549 alveolar epithelial cells to undergo EMT via Smad2 activation. Our data support the concept of EMT in lung epithelial cells, and suggest the need for further studies to investigate the phenomenon

Zinc and Diabetes: A Connection between Micronutrient and Metabolism

Diabetes mellitus is a global health problem and a major contributor to mortality and morbidity. The management of this condition typically involves using oral antidiabetic medication, insulin, and appropriate dietary modifications, with a focus on macronutrient intake. However, several human studies have indicated that a deficiency in micronutrients, such as zinc, can be associated with insulin resistance as well as greater glucose intolerance. Zinc serves as a chemical messenger, acts as a cofactor to increase enzyme activity, and is involved in insulin formation, release, and storage. These diverse functions make zinc an important trace element for the regulation of blood glucose levels. Adequate zinc levels have also been shown to reduce the risk of developing diabetic complications. This review article explains the role of zinc in glucose metabolism and the effects of its inadequacy on the development, progression, and complications of diabetes mellitus. Furthermore, it describes the impact of zinc supplementation on preventing diabetes mellitus. The available information suggests that zinc has beneficial effects on the management of diabetic patients. Although additional large-scale randomized clinical trials are needed to establish zinc’s clinical utility further, efforts should be made to increase awareness of its potential benefits on human health and disease

DMOSYS: defect-monitoring system for building maintenance at polytechnic

Maintenance management could be a complex subject if implementation and planning issues of the building facility are not handled properly. In this context, the current maintenance management method has affected the efficiency of the building facility management at Polytechnics. Many issues such as poor service delivery, inadequate finance, poor maintenance planning and maintenance backlogs were emerged due to the usage of conventional method application (paper-based form and unsystematic database). Therefore, this research is to review existing maintenance management practices, and subsequently develop a prototype system based on the stated problems related to the conventional method in improving the maintenance management processes. Literature review and semi-structured interview was carried out to achieve the objectives. Eight Polytechnics are selected based on major problems of using conventional method in the comparison to investigate the maintenance management practices in each Polytechnic. There are around 32 Polytechnics in Malaysia and almost are using conventional methods. The number is considered very big indicating that the use of modern Information and Communication Technology (ICT) is still very limited compared to other institutions of higher learning in Malaysia. The results revealed that the practice of maintenance management at Polytechnics needs to be improved and a computerised system was proposed based on the requirements of a maintenance management system identified through the case studies. The framework was encapsulated in a computer-based prototype system based on Microsoft Visual Basic.Net as a graphical user-interface while for the database design, the Microsoft Access is used to deploy the information for maintenance management processes. The computerised system was developed using Data Flow Diagram (DFD) and coding. Subsequently, the prototype system was tested by running it until the critical problems were fixed and its functional requirements work correctly. This system will help with the building diagnosis and decision making process approaches. It will assist staff in facilitating the maintenance identification, assessment, planning and execution in relation to building facility. In conclusion, the developed prototype system can improve the maintenance management practices effectiveness for building facility to provide highquality building facility for safe and healthy environment

Integrating CMMS, expert systems and BIM for IBS building maintenance

Current methods of maintenance management have affected the efficiency of the relevant tasks when applied to the industrialised building system (IBS) for high-rises in Malaysia. Many issues, such as poor service delivery, limited budgets, incompetent staff and defect repetition, have emerged from the use of conventional methods of application (paper-based forms). A total of 73.5% of IBS building maintenance tasks in Malaysia feature the conventional method. Data have revealed that the practice of maintenance management for IBS high-rise buildings needs to be digitalised. Therefore, this paper reviews current practices in maintenance management and develops a Building Information Modelling (BIM) prototype system that addresses problems with to the conventional method to improve the processes of maintenance management. This qualitative research was carried out by conducting a literature review and semi-structured interviews. Eight major maintenance organisations were selected based on the conventional method of practice in managing maintenance for IBS high-rise buildings. The framework was represented in a computer-based prototype system in Autodesk Revit to allow multidisciplinary information to be superimposed onto a digital building model, Microsoft Visual Basic.Net was used as graphical-user interface while Microsoft Access was used for database design to deploy information on maintenance management processes. The computerised system was developed using data flow diagrams and coding. The prototype system was then tested, and the results show that it makes defect diagnosis and decision-making process easier, faster, and cost effective while facilitating the assessment of maintenance, defect diagnosis, and control in relation to components of IBS building structures. In conclusion, the prototype system can improve the effectiveness of maintenance management practices for components of the IBS building structure by reducing the risk of defects in design, such as the design calculation error, to provide high-quality components for the structure to ensure a safe and healthy environment

EDUKASI PENCEGAHAN STUNTING MELALUI PENINGKATAN FUNGSI PEKARANGAN RUMAH SEBAGAI SUMBER PANGAN

Tingginya angka stunting di Labuan Bajo, terutama di Pulau Rinca, Indonesia, menjadi isu serius yang erat kaitannya dengan masalah malnutrisi. Masyarakat Pulau Rinca mengalami kesulitan dalam mengakses sumber pangan akibat kendala penyeberangan pulau dan juga mengkhawatirkan serangan hewan, terutama kambing dan komodo, saat membuka lahan pertanian sehingga dibutuhkan solusi untuk mengatasi masalah ini dengan meningkatkan pemanfaatan pekarangan rumah oleh masyarakat untuk memenuhi kebutuhan pangan. Metode kegiatan pengabdian masyarakat ini melalui penyuluhan dan pelatihan tentang stunting dan pemanfaatan pekarangan rumah. Tahapan kegiatan meliputi tahap survei dan administrasi, Focus Group Discussion (FGD), dan implementasi. Hasil dari pengabdian masyarakat ini menunjukkan antusiasme tinggi peserta pelatihan terhadap environment project ini, yang dapat meningkatkan pengetahuan mereka tentang penanaman sayuran di pekarangan rumah sebagai upaya mengurangi tingkat stunting, terutama di Desa Pasir Panjang, Pulau Rinca. Adanya kegiatan penanaman sayuran di pekarangan rumah dapat meningkatkan ketersediaan sayuran segar dan kesadaran akan pentingnya konsumsi sayur dalam mencegah stunting

Simulated interventions to ameliorate age-related bone loss indicate the importance of timing

Bone remodeling is the continuous process of bone resorption by osteoclasts and bone formation by osteoblasts, in order to maintain homeostasis. The activity of osteoclasts and osteoblasts is regulated by a network of signaling pathways, including Wnt, parathyroid hormone (PTH), RANKL/OPG and TGF-β, in response to stimuli such as mechanical loading. During aging there is a gradual loss of bone mass due to dysregulation of signaling pathways. This may be due to a decline in physical activity with age and/or changes in hormones and other signaling molecules. In particular, hormones such as PTH have a circadian rhythm which may be disrupted in aging. Due to the complexity of the molecular and cellular networks involved in bone remodeling, several mathematical models have been proposed to aid understanding of the processes involved. However, to date there are no models which explicitly consider the effects of mechanical loading, the circadian rhythm of PTH and the dynamics of signaling molecules on bone remodeling. Therefore, we have constructed a network model of the system using a modular approach which will allow further modifications as required in future research. The model was used to simulate the effects of mechanical loading and also the effects of different interventions such as continuous or intermittent administration of PTH. Our model predicts that the absence of regular mechanical loading and/or an impaired PTH circadian rhythm leads to a gradual decrease in bone mass over time which can be restored by simulated interventions and that the effectiveness of some interventions may depend on their timing