PERENCANAAN ULANG DESAIN FASILITAS TEMPAT PENGOLAHAN SAMPAH TERPADU PADA KAWASAN KAMPUS III UNIVERSITAS MUHAMMADIYAH MALANG

University of Muhammadiyah Malang is a university located in Malang City, East Java. Each year the University of Muhammadiyah Malang experiences an increase the number of students, the volume of waste generated also increase. Waste is a very important problem to address, waste can be a source of disease and cause other nnatural damage. At the University of Muhammadiyah Malang there is already waste collection site and it is not running optimally. The method used in this research is based on SNI 19-3964-1994 to calculate the amount of waste generation. Planning for the re-design TPST 3R at The University of Muhammadiyah Malang is planned for the next 5 years with a service level of 93,4%. Development is planned based on an analysis of land requirements, which includes dropping and sorting area, composting areas, compost and stall storage, as well as other TPST 3R supporting buildings such as warehouse, toilets, and container parking areas. The re-design of TPST 3R University of Muhammadiyah Malang requires a cost of Rp. 613.288.990

Class Anxieties at the Britain Can Make It Exhibition: The Uses of (Design) Literacy* (*with apologies to Richard Hoggart)

The most widely represented class was very definitely the artisan working class. Only 1 in 200 said that they thought the exhibition was bad. A dockworker’s wife expressed approval of the plastic kitchen cabinets because she thought “They do keep the mice out.” The COID and British design establishment, through its literature and exhibitions, consistently reinforced the view that good taste in design was a disposition segregated by class. Archive documents show that the BCMI exhibition and accompanying COID publications, were to be instrumental in “raising the public to a state of alert sensibility and giving it a lead” and relied on the hope that the visiting public would “get the idea for itself” and subsequently make better taste decisions. Unfortunately, when left to ‘get the idea for itself’ the public would so often get entirely the wrong idea that the necessity for intervention became clear. The need for some form of conventional ‘design literacy’ was essential. Indeed ‘design literacy’ was to be a government watchword for many years post BCMI and embodied frequent vain attempts to reform working class taste. In contrast to this were the works produced by Dennis Chapman and Richard Hoggart that celebrated difference and documented the shifting nature of authentic working class taste and domestic conditions, exposing the premise for their style and tastes, analyzing working class domestic interiors and objects taking into account the culture that produced them. This paper examines the uses of ‘design literacy’ in the BCMI exhibition and the continued failure of the project seventy years on

Quantifying engineered nanomaterial toxicity: comparison of common cytotoxicity and gene expression measurements

BACKGROUND: When evaluating the toxicity of engineered nanomaterials (ENMS) it is important to use multiple bioassays based on different mechanisms of action. In this regard we evaluated the use of gene expression and common cytotoxicity measurements using as test materials, two selected nanoparticles with known differences in toxicity, 5 nm mercaptoundecanoic acid (MUA)-capped InP and CdSe quantum dots (QDs). We tested the effects of these QDs at concentrations ranging from 0.5 to 160 µg/mL on cultured normal human bronchial epithelial (NHBE) cells using four common cytotoxicity assays: the dichlorofluorescein assay for reactive oxygen species (ROS), the lactate dehydrogenase assay for membrane viability (LDH), the mitochondrial dehydrogenase assay for mitochondrial function, and the Comet assay for DNA strand breaks. RESULTS: The cytotoxicity assays showed similar trends when exposed to nanoparticles for 24 h at 80 µg/mL with a threefold increase in ROS with exposure to CdSe QDs compared to an insignificant change in ROS levels after exposure to InP QDs, a twofold increase in the LDH necrosis assay in NHBE cells with exposure to CdSe QDs compared to a 50% decrease for InP QDs, a 60% decrease in the mitochondrial function assay upon exposure to CdSe QDs compared to a minimal increase in the case of InP and significant DNA strand breaks after exposure to CdSe QDs compared to no significant DNA strand breaks with InP. High-throughput quantitative real-time polymerase chain reaction (qRT-PCR) data for cells exposed for 6 h at a concentration of 80 µg/mL were consistent with the cytotoxicity assays showing major differences in DNA damage, DNA repair and mitochondrial function gene regulatory responses to the CdSe and InP QDs. The BRCA2, CYP1A1, CYP1B1, CDK1, SFN and VEGFA genes were observed to be upregulated specifically from increased CdSe exposure and suggests their possible utility as biomarkers for toxicity. CONCLUSIONS: This study can serve as a model for comparing traditional cytotoxicity assays and gene expression measurements and to determine candidate biomarkers for assessing the biocompatibility of ENMs.1R01GM84702-01 - National Institute of General Medical Science

Controlled Clinical Trial of a Self-Help for Anxiety Intervention for Patients Waiting for Psychological Therapy

This study was a controlled clinical trial in which patients were offered a brief low cost, low intensity self-help intervention while waiting for psychological therapy. A CBT based self-help pack was given to patients with significant anxiety problems and no attempt was made to exclude patients on the basis of severity or co-morbidity. The treatment group received the intervention immediately following assessment and the control group after a delay of 8 weeks so comparisons between the two groups were made over 8 weeks. Although there was some support for the effectiveness of the self help intervention, with a significant time x group interaction for CORE-OM scores, this was not significant with the intention to treat analysis, nor for HADS anxiety and depression scores and the effect size was low. A follow up evaluation suggested some patients attributed significant goal attainment to the intervention. The findings suggest the routine use of self-help interventions in psychological therapies services should be considered although further more adequately powered research is required to identify the type of patients and problems that most benefit, possible adverse effects and the effect on subsequent uptake of and engagement in therapy

Light scattering and phase behavior of Lysozyme-PEG mixtures

Measurements of liquid-liquid phase transition temperatures (cloud points) of mixtures of a protein (lysozyme) and a polymer, poly(ethylene glycol) (PEG) show that the addition of low molecular weight PEG stabilizes the mixture whereas high molecular weight PEG was destabilizing. We demonstrate that this behavior is inconsistent with an entropic depletion interaction between lysozyme and PEG and suggest that an energetic attraction between lysozyme and PEG is responsible. In order to independently characterize the lysozyme/PEG interactions, light scattering experiments on the same mixtures were performed to measure second and third virial coefficients. These measurements indicate that PEG induces repulsion between lysozyme molecules, contrary to the depletion prediction. Furthermore, it is shown that third virial terms must be included in the mixture's free energy in order to qualitatively capture our cloud point and light scattering data. The light scattering results were consistent with the cloud point measurements and indicate that attractions do exist between lysozyme and PEG.Comment: 5 pages, 2 figures, 1 tabl

Clinical characteristics of persistent frequent attenders in primary care: case–control study

Background. Most frequent attendance in primary care is temporary, but persistent frequent attendance is expensive and may be suitable for psychological intervention. To plan appropriate intervention and service delivery, there is a need for research involving standardized psychiatric interviews with assessment of physical health and health status. Objective. To compare the mental and physical health characteristics and health status of persistent frequent attenders (FAs) in primary care, currently and over the preceding 2 years, with normal attenders (NAs) matched by age, gender and general practice. Methods. Case–control study of 71 FAs (30 or more GP or practice nurse consultations in 2 years) and 71 NAs, drawn from five primary care practices, employing standardized psychiatric interview, quality of life, health anxiety and primary care electronic record review over the preceding 2 years. Results. Compared to NAs, FAs were more likely to report a lower quality of life (P < 0.001), be unmarried (P = 0.03) and have no educational qualifications (P = 0.009) but did not differ in employment status. FAs experienced greater health anxiety (P < 0.001), morbid obesity (P = 0.02), pain (P < 0.001) and long-term pathological and ill-defined physical conditions (P < 0.001). FAs had more depression including dysthymia, anxiety and somatoform disorders (all P < 0.001). Conclusions. Persistent frequent attendance in primary care was associated with poor quality of life and high clinical complexity characterized by diverse and often persistent physical and mental multimorbidity. A brokerage model with GPs working in close liaison with skilled psychological therapists is required to manage such persistent complexity

Cognitive behaviour therapy for long-term frequent attenders in primary care: a feasibility case series and treatment development study

Background: Most frequent attendance in primary care is temporary. Long-term frequent attendance may be suitable for psychological intervention to address health management and service use. Aim: To explore the feasibility and acceptability of cognitive-behaviour therapy (CBT) for long-term frequent attendance in primary care and obtain preliminary evidence regarding clinical and cost-effectiveness. Design and Setting: A CBT case series was carried out in five GP practices. Method: Frequent attenders (FAs) were identified from case notes and invited by their practice for assessment, then offered CBT. Feasibility and acceptability were assessed by CBT session attendance and thematic analysis of semi-structured questionnaires. Clinical and cost effectiveness was assessed by primary care use and clinically important change on a range of health and quality of life instruments. Results: Of 462 FAs invited to interview, 87 (19%) consented to assessment. Thirty-two (7%) undertook CBT over median three months. Twenty-four (75%) attended > 6 sessions. Eighteen FAs (86%, n=21) reported overall satisfaction with treatment. Patients reported valuing listening without judgement alongside support to develop coping strategies. Thirteen (55%, n=24) achieved clinically important improvement on the SF-36 Mental-Component Scale at six month follow-up and improved quality of life, but no improvement on other outcomes. Primary care use reduced from median eight contacts in three months at baseline (n=32) to three contacts in three months at one year (n=18). Conclusion: CBT appears feasible and acceptable to a sub-set of long-term FAs in primary care who halved their primary care use. With improved recruitment strategies, this approach might contribute to decreasing GP workload and merits larger-scale evaluation

Strategies for Christian Educators and Administrators to move from pre-pandemic VUCA reaction to post-pandemic VUCA 2.0 response.

Abstract Pre-pandemic Volatile, Uncertain, Complex and Ambiguous (VUCA) realities added specific complexity to education and administrative practice at Christian schools, influencing Christian school educators and administrator reactions to the challenges experienced in their social and professional contexts (Ungerer, Ungerer and Herholdt, 2016). Post-pandemic realities however, will require greater diligence for Christian educators and administrators. The transition from pre-pandemic reactive responses to VUCA influence on Christian school environments to applying visionary, understandable, courageous and adaptive (VUCA 2.0) strategic principles for those same environments, is a necessary strategic challenge to accept. Christian school educators and administrators wanting to support a healthy and effective whole school practice and affirm identity, mission, purpose and strategic practice in a post pandemic environment must push through the fog of reaction and commit themselves to VUCA 2.0 success (George, 2017)

A Sacramental Model for Digital Ecclesiology: Theological Retrieval for a Mediated Church

The widespread proliferation of digital technologies has opened the door to new ecclesiological questions and challenges for the Christian denominations that have integrated these technologies into their community life and liturgical practices. American evangelicalism is proposed to be especially susceptible to the aforementioned challenges due to its ecclesiological emphases and general posture towards digital media. Using Marshall McLuhan’s seminal insights in media theory, this work argues that the role of digital media in the church shows a significant congruence with Christian sacramental theology. The concept of the digital church is analyzed through McLuhan’s tetrad framework and its weaknesses are highlighted. This work presents a solution by arguing that viewing the church as a sacrament may alleviate the potential dangers of churches being negatively impacted by an unbalanced theology of media