Geologic cross sections across the Mahomet Bedrock Valley ; Champaign, Ford, McLean, Piatt, and Vermilion Counties, Illinois

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Subcutaneous Immunoglobulin Replacement Therapy with Hizentra® is Safe and Effective in Children Less Than 5 Years of Age.

BACKGROUND:Hizentra® (IGSC 20%) is a 20% liquid IgG product approved for subcutaneous administration in adults and children 2 years of age and older who have primary immunodeficiency disease (PIDD). There is limited information about the use of IGSC 20 % in very young children including those less than 5 years of age. METHODS:A retrospective chart review involved 88 PIDD infants and children less than 5 years of age who received Hizentra®. RESULTS:The mean age at the start of Hizentra® was 34 months (range 2 to 59 months). IGSC 20 % was administered weekly to 86 infants (two additional infants received twice weekly and three times weekly infusions, respectively) and included an average of 63 infusions (range 6-182) for an observation period up to 45.5 months. Infusion by manual delivery occurred in 15 patients. The mean dose was 674 mg/kg/4 weeks. The mean IgG level was 942 mg/dL while on IGSC 20 %, compared to a mean trough IgG level of 794 mg/dL (p < 0.0001) during intravenous or subcutaneous IgG administration prior to IGSC 20 %. Average infusion time was 47 (range 5-120) minutes, and the median number of infusion sites was 2 (range 1-4). Local reactions were mostly mild and observed in 36/88 (41%) children. No serious adverse events were reported. A significant increase in weight percentile (7 % ± 19.2, p = 0.0012) among subjects was observed during IGSC 20% administration. The rate of serious bacterial infections was 0.067 per patient-year while receiving IGSC 20%, similar to previously reported efficacy studies. CONCLUSIONS:Hizentra® is effective in preventing infections, and is well tolerated in children less than age 5 years

Reading recovery : impact of an early intervention approach

This study involved 12 participants from an elementary school in a rural district including: two classroom teachers, three randomly selected Reading Recovery students, three parents of the randomly selected Reading Recovery students, and four randomly selected non-Reading Recovery students. The primary purpose of this study was to track progress of the selected Reading Recovery students throughout the course of their program. Results indicated that the selected Reading Recovery students functioned at an average performance level at the end of their program compared to a sample of non-Reading Recovery peers who performed at a higher level. Interviews from participating classroom teachers revealed observed accelerated progress of the selected Reading Recovery students. There was an increase in their concepts about print skills, ability to compose stories, and use of reading and writing strategies. Frequent communication between classroom teachers and the Reading Recovery teachers revealed that teacher expectations of target students increased and a common language of prompts was established between the Reading Recovery and classroom teachers. Finally, feedback from participants\u27 parents was very positive. Interviews indicated that time spent reading and writing at home increased and became an integral part of the families\u27 daily routine. Recommendations include: to continue tracking of the participating Reading Recovery students throughout the elementary grades to reaffirm these findings, to improve communication between Reading Recovery and classroom teachers to support student transfer of learning in both environments, and to inservice parents to increase the quality of home support

Panel. Revisioning Miscegenation and Trauma in Faulkner and the African American South

Miscegenation and Progression: The First Americans of Jean Toomer and William Faulkner / Andrew Leiter, Lycoming CollegeNatasha Trethewey\u27s Joe Christmas and the Reconstruction of Mississippi Nativity / Ted Atkinson, Mississippi State UniversityContemporary Black Writing and Southern Social Belonging Beyond the Faulknerian Shadow of Loss / Lisa Hinrichsen, University of Arkansa

Subsurface Analysis of Late Illinoian Deglacial Sediments in East-Central Illinois, United States, and Its Implications for Hydrostratigraphy

During the Illinoian glaciation (approximately 180,000 to 125,000 years ago) glacial lobes advancing into Illinois deposited an extensive till sheet (i.e., the Vandalia Member till). However, very little is known about the retreat phase that followed this major ice advance. Erosional events and the heterogeneous sediments associated to the Illinoian deglaciation may also have important hydrogeologic implications. Specifically, the occurrence and emplacement of these heterogeneous deposits, informally referred to as the Glasford deglacial unit, into and overlying the Vandalia Member till, may impact the integrity of this extensive till aquitard, and possibly influence groundwater flow to the deeper and regionally important Mahomet aquifer. Thus, the purpose of this research is to improve knowledge of the heterogeneous character of the Glasford deglacial sediments and their three-dimensional (3-D) hydrostratigraphic architecture. The methodology to study the Glasford deglacial unit relies on the detailed analysis of 7 continuous cores and interpretations of 4 geophysical profiles, which provide key stratigraphic control to estimate unit geometry and establish the vertical succession of facies assemblages in the unit. A 3-D geological model was created using gOcad®, a geomodelling software, across a 2642 square kilometer study area and the deglacial unit having a subsurface volume domain of 5.70E+9 cubic meters. Utilizing all available data sources including 38 continuous cores, 69 downhole geophysical logs, 799 driller’s logs, and 4 near-surface geophysical profiles; triangulated surfaces were interpolated representing the top and bottom of the Glasford deglacial unit and key internal layers. These surfaces provided a framework for a 3-D cellular partition, where descretizing the model allowed for mapping of hydrofacies assemblages that represented mappable heterogeneities of coarse- and fine-grained sediment in the Glasford deglacial unit. Results of the subsurface facies analysis led to the identification of three main facies types that form the Glasford deglacial unit: 1) massive, matrix-supported diamicton; 2) interstratified sand and gravel; and 3) fine-grained massive and/or bedded sediment. Using key seismic reflectors and interpretations based on near-surface seismic profiles as well as geologic logs from numerous boreholes, these facies were assigned to two features of possible regional extent: 1) a broad channelized erosion surface informally named the Champaign valley; and 2) an extensive tabular unit overlying the valley fill and extending across the entire study area. Grouping of facies into distinct facies assemblages was useful to distinguish sediments that in-fill either the Champaign valley or compose the tabular unit. Major heterogeneities have been recognized in these features and mapped at regional scale represented by fine- and coarse-grained sediment assemblages that comprise 46% and 54% respectively of the Glasford deglacial unit volume. Laterally continuous coarse-grained sediment assemblages are primarily located in the Champaign valley and potentially represent local aquifers of limited but usefully productivity for east-central Illinois. These small aquifers are characterized by hydraulic conductivities ranging from 1.07E-3 m/s to 1.78E-6 m/s. Fine-grained sediment assemblages have an average hydraulic conductivity value of 4.38E-8 m/s and thus may represent discontinuous aquitards impeding water flow. However, these fine-grained sediment assemblages cannot be considered homogeneous aquitards because of their textural variability and limited lateral continuity. The geological model developed in this study contributes to better understanding the complex subsurface geology in east-central Illinois. Results of this study confirm the high degree of heterogeneity in the Glasford deglacial unit that includes features of glacial erosion, and these findings question, at least locally, the integrity of the underlying Vandalia Member till as a regional aquitard unit. Overall, the Glasford deglacial unit is a complex subsurface ice-marginal package of sediments, which challenges the aquifer-aquitard concept. It is argued herein that some ice-contact or ice-marginal sediments units may be laterally extensive as a whole, yet internally too heterogeneous to be mapped as an aquifer or aquitard at a regional scale. A new conceptual hydrostratigraphic layer, the hybrid layer (part-aquifer/ part-aquitard), is thus proposed to better describe these units. This new hybrid layer is meant to augment the traditional aquifer/aquitard concept representing hydrostratigraphic bodies that may not form laterally extensive aquifer or aquitard units. These hybrid layers may better represent conceptually the complex ice-marginal deposits that are found across east-central Illinois, and perhaps other similar areas affected by glacial lobe fluctuations during multiple glaciations

Genome sequence of human papillomavirus type 20, strain HPV-20/Lancaster/2015

The genome sequence of human papillomavirus type 20 (HPV-20; family Papillomaviridae, genus Betapapillomavirus, species Betapapillomavirus 1, type 20) was assembled by deep sequencing from nasopharyngeal swabs. The assembled genome is 0.37% divergent over its full length from the single complete genome of HPV-20 in GenBank (U31778). We named the strain HPV-20/Lancaster/2015

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

The ATLAS3D project - XXIX : The new look of early-type galaxies and surrounding fields disclosed by extremely deep optical images

Date of Acceptance: 25/09/2014Galactic archaeology based on star counts is instrumental to reconstruct the past mass assembly of Local Group galaxies. The development of new observing techniques and data reduction, coupled with the use of sensitive large field of view cameras, now allows us to pursue this technique in more distant galaxies exploiting their diffuse low surface brightness (LSB) light. As part of the ATLAS3D project, we have obtained with the MegaCam camera at the Canada-France-Hawaii Telescope extremely deep, multiband images of nearby early-type galaxies (ETGs). We present here a catalogue of 92 galaxies from the ATLAS3D sample, which are located in low- to medium-density environments. The observing strategy and data reduction pipeline, which achieve a gain of several magnitudes in the limiting surface brightness with respect to classical imaging surveys, are presented. The size and depth of the survey are compared to other recent deep imaging projects. The paper highlights the capability of LSB-optimized surveys at detecting new prominent structures that change the apparent morphology of galaxies. The intrinsic limitations of deep imaging observations are also discussed, among those, the contamination of the stellar haloes of galaxies by extended ghost reflections, and the cirrus emission from Galactic dust. The detection and systematic census of fine structures that trace the present and past mass assembly of ETGs are one of the prime goals of the project. We provide specific examples of each type of observed structures - tidal tails, stellar streams and shells - and explain how they were identified and classified. We give an overview of the initial results. The detailed statistical analysis will be presented in future papers.Peer reviewedFinal Accepted Versio

Teacher education in practice: Reconciling contexts, practices, and theories

This is the author's accepted manuscript. The original publication is available at http://dx.doi.org/10.1080/08856257.2013.778114.This paper reports findings from an 18-month qualitative study that followed the experiences of nine teacher residents, their site professors, site coordinators, clinical teachers and principals in three professional learning schools. The study examined the tensions that emerged as teacher preparation theory intersected with the context-bound realities of daily life in schools and the political constraints that diminish possibilities for inclusive education. The paper addresses implications for teacher preparation programmes by reporting how teacher residents negotiated their understanding of and commitment for inclusive education through three themes: (a) critical reflection as an emergent practice, (b) whose learning, and (c) the trouble with behaviour. Interpreting these themes has implications for programmatic designs in teacher preparation