SELF DOUBLE EMULSIFYING DRUG DELIVERY SYSTEM (SDEDDS): A REVIEW

Self emulsifying drug delivery systems (SEDDS) are well known for its potential to improve the aqueous solubility and oral absorption of lipophilic drugs. Self double-emulsifying drug delivery system (SDEDDS) are basically used for drugs having low solubility in water, but its potential application for the drugs defined as “high solubility low permeability class†or a biopharmaceutical classification system [BCS] class III drug is appreciable, in which gastrointestinal permeation is the rate controlling step in the absorption process. The most important factor affecting the oral absorption of a drug, besides dissolution, is the permeability of the drug across the gastrointestinal lining. Improving permeability may, therefore, potentially improve the bioavailability of a drug. In this review we discuss the preparation, stability, formulation and characterization of SDEDDS.   Key Words: Multiple emulsion, self emulsifying, Protein peptide drug delivery, High soluble poorly permeable drugs

Performance of nano-bio-lubricants, ISO VG46 oil and its blend with Jatropha oil in statically loaded hydrodynamic plain journal bearing

In this experimental study, three stable nano-bio-lubricants were prepared by dispersing CuO nanoparticles in three bio-lubricants and later investigations were carried out to determine pressure distribution and frictional performance of ISO VG46 oil, bio-lubricants and nano-bio-lubricants in hydrodynamic journal bearing under different loads and speeds. The experimental results revealed that pressure of oils inside bearing depends on viscosity of oils. Addition of nanoparticles in bio-lubricants did not help to enhance the maximum pressure of oil inside bearing. Frictional performance of ISO VG46 oil and bio-lubricants was according to their viscosity but coefficient of friction of nano-bio-lubricants was higher compared to ISO VG46 oil inspite of having approximately same viscosity compared to ISO VG46 oil. Among all the oils, ISO VG46 oil and bio-lubricant 9010 had similar performance and hence Bio-lubricant 9010 can be used in place of ISO VG46 oil in journal bearing. </jats:p