H Syndrome retrospectively diagnosed: The importance of recognizing cutaneous signs

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Serology of Lupus Erythematosus: Correlation between Immunopathological Features and Clinical Aspects

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the aberrant production of a broad and heterogenous group of autoantibodies. Even though the presence of autoantibodies in SLE has been known, for more than 60 years, still nowadays a great effort is being made to understand the pathogenetic, diagnostic, and prognostic meaning of such autoantibodies. Antibodies to ds-DNA are useful for the diagnosis of SLE, to monitor the disease activity, and correlate with renal and central nervous involvements. Anti-Sm antibodies are highly specific for SLE. Anti-nucleosome antibodies are an excellent marker for SLE and good predictors of flares in quiescent lupus. Anti-histone antibodies characterize drug-induced lupus, while anti-SSA/Ro and anti-SSB/La antibodies are associated with neonatal lupus erythematosus and photosensitivity. Anti-ribosomal P antibodies play a role in neuropsychiatric lupus, but their association with clinical manifestations is still unclear. Anti-phospholipid antibodies are associated with the anti-phospholipid syndrome, cerebral vascular disease, and neuropsychiatric lupus. Anti-C1q antibodies amplify glomerular injury, and the elevation of their titers may predict renal flares. Anti-RNP antibodies are a marker of Sharp’s syndrome but can be found in SLE as well. Anti-PCNA antibodies are present in 5–10% of SLE patients especially those with arthritis and hypocomplementemia

Factores de riesgo de violencia familiar en el Centro Emergencia Mujer Comisaría Huancayo, 2023

El título de esta investigación fue: Factores de riesgo de violencia familiar en el Centro Emergencia Mujer Comisaría Huancayo, 2023. Siendo el objetivo general determinar los factores de riesgo de violencia familiar en el Centro Emergencia Mujer Comisaría Huancayo, 2023. La metodología correspondió a un estudio de enfoque cuantitativo, tipo básico, nivel correlacional y diseño correlacional causal, la población fue de 853 expedientes y la muestra calculada mediante un muestreo probabilístico fue de 265 expedientes. La técnica de recolección de datos fue observacional y el instrumento una ficha de observación. Los resultados de parte del agresor encontrados fueron que la mayoría de ellos no tenían antecedentes en el 95.5% de los casos; y en la situación actual de violencia, hay un nivel bajo de agresión en el 83.4% de los casos. En cuanto a la víctima los factores personales no se presentaron en el 99.6%, y factores interrelaciónales también estuvieron ausente en el 87.2%. Se concluye que los factores de riesgo de violencia familiar en el Centro Emergencia Mujer Comisaría Huancayo, 2023 son: De parte del agresor es la situación actual (p=0.005 < 0.05), y de parte de la víctima no hay factores relacionados con la violencia familiar ((p > 0.05)

Endothelin-1 Levels in Scleroderma Patients: A Pilot Study

Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, which mediates vascular wall cells proliferation, fibrosis, and inflammation through two types of ET-1 receptors (ET-A and ET-B). In our retrospective study the serum levels of ET-1 in 18 systemic sclerosis (SSc) patients with and without digital ulcers (DUs) were assessed to observe possible correlation between the levels of ET-1, the evolution of SSc, and the therapy with an ET-1 antagonist (bosentan). In all our patients, the levels of ET-1 were found higher than normal range and correlate with the severity of the disease. Furthermore we also observed that in patients without DUs the levels of ET-1 were higher and did not correlate with new DUs development. In conclusion, the levels of ET-1 in our studied patients do not correlate with the possible development of DUs. The reduction of ET-1 levels in DUs patients in therapy with bosentan confirms the efficacy of this molecule both for treatment and prevention of digital ulcers. The inhibition of ET-A receptor by its antagonist may activate the opposite ET-B receptors, with well-known function ET-1 degradation and reducing of ET-1 serum level as confirmed in our pilot study.</jats:p

Results of COVID-19 screening in a dermatologic clinic in northern Italy

Introduction The COVID-19 pandemic has been a social, economic and sanitary challenge, which caused a great slowdown in most clinical activities. At the beginning of 2021, the gradual reopening of outpatient services was threatened by the risk of COVID-19 outbreaks in healthcare facilities. Methods Between January and March 2021, our dermatologic clinic promoted a screening campaign based on rapid antigen-testing: adhering patients were tested for COVID-19 and were visited only after getting a negative result. Results Among 635 recruited subjects, 514 agreed to be enrolled in the study, while 121 refused and were not tested. Only 1 of the 514 tests was positive for COVID-19, thus the incidence of COVID-19 infections was very low (0,002%). A significant percentage of patients (19,1%) refused to be tested. Among those who did not give consent for COVID-19 testing, 52,9% were male, although the total recruited population was prevalently female (56,1%). Discussion and conclusions Screening for COVID-19 in outpatient clinics is a promising tool to prevent virus outbreaks, despite the limitations posed by testing hesitancy. Moreover, the very low incidence of COVID-19 infection we detected could be seen as a sign of hope for the resumption of non-essential clinical activities

Case report: Psoriasiform eczema with immune-mediated comorbidities treated with upadacitinib

Immune-mediated comorbidities in patients with psoriasiform eczema are common. It can be challenging to manage multiple immune-mediated diseases, especially considering that biologic treatments are prone to causing paradoxical effects. The aim of this retrospective observational case series was to describe the course of both psoriasiform eczema and immune-mediated comorbidities in five patients treated with upadacitinib for psoriasiform dermatitis. Five patients, all male, were included. All the patients suffered from psoriasiform eczema. Moreover, two of the patients suffered from alopecia areata, two from vitiligo, one from ulcerative colitis and one from hidradenitis suppurativa. In all cases, the treatment with upadacitinib was rapidly effective on the eczema. The effectiveness on alopecia areata was good in both cases, while the results on vitiligo were only partial. The only case of ulcerative colitis achieved complete remission, while the case of hidradenitis suppurativa experience partial improvement. In conclusion, upadacitinib was effective in treating not only psoriasiform eczema, but also several immune mediated comorbidities. Additional studies are necessary to determine the efficacy of upadacitinib in alopecia areata, vitiligo and hidradenitis suppurativa

¡Pará un Cacho!: letras misóginas de un cantante popular

Traemos para compartir un trabajo realizado en la Cátedra de Estética / Fundamentos Estéticos, comisión siete. Este trabajo es de participación grupal, realizado bajo una consigna común a todas las comisiones de la cátedra, siendo su aceptación requisito para la aprobación de la asignatura. La modalidad de trabajo consistió en elaborar, desde el marco teórico (bibliografía de las unidades del programa), un escrito abordando producciones artísticas de alguno/os integrantes del grupo, produciendo un artículo de arte en formato de publicación para revista cultural. De este modo la producción “Los machos dicen. No al discurso machista”, obra de arte de acción participativa que fuera realizada en el patio de la sede Fonseca de nuestra Facultad, es abordada por los integrantes del grupo, con una otra mirada, problematizadora y enriquecida desde lo conceptual. La obra seleccionada para su análisis plantea desde el arte una reflexión acerca de la violencia implícita y explícita contra la mujer en canciones populares, en este caso aquella de Cacho Castaña: “Si te agarro con otro te mato”; en relación que estas producciones reproducen, naturalizan y fomentan las prácticas violentas hacia la mujer.Facultad de Bellas Arte

¡Pará un Cacho!: letras misóginas de un cantante popular

Traemos para compartir un trabajo realizado en la Cátedra de Estética / Fundamentos Estéticos, comisión siete. Este trabajo es de participación grupal, realizado bajo una consigna común a todas las comisiones de la cátedra, siendo su aceptación requisito para la aprobación de la asignatura. La modalidad de trabajo consistió en elaborar, desde el marco teórico (bibliografía de las unidades del programa), un escrito abordando producciones artísticas de alguno/os integrantes del grupo, produciendo un artículo de arte en formato de publicación para revista cultural. De este modo la producción “Los machos dicen. No al discurso machista”, obra de arte de acción participativa que fuera realizada en el patio de la sede Fonseca de nuestra Facultad, es abordada por los integrantes del grupo, con una otra mirada, problematizadora y enriquecida desde lo conceptual. La obra seleccionada para su análisis plantea desde el arte una reflexión acerca de la violencia implícita y explícita contra la mujer en canciones populares, en este caso aquella de Cacho Castaña: “Si te agarro con otro te mato”; en relación que estas producciones reproducen, naturalizan y fomentan las prácticas violentas hacia la mujer.Facultad de Bellas Arte