High-K volcanism in the Afyon region, western Turkey: from Si-oversaturated to Si-undersaturated volcanism

Volcanic rocks of the Afyon province (eastern part of western Anatolia) make up a multistage potassic and ultrapotassic alkaline series dated from 14 to 12 Ma. The early-stage Si-oversaturated volcanic rocks around the Afyon city and further southward are trachyandesitic volcanic activity (14.23 ± 0.09 Ma). Late-stage Si-undersaturated volcanism in the southernmost part of the Afyon volcanic province took place in three episodes inferred from their stratigraphic relationships and ages. Melilite– leucitites (11.50 ± 0.03 Ma), spotted rachyandesites, tephryphonolites and lamproites (11.91 ± 0.13 Ma) formed in the first episode; trachyandesites in the second episode and finally phonotephrites, phonolite, basaltic trachyandesites and nosean-bearing trachyandesites during the last episode. The parameter Q [normative q-(ne + lc + kls + ol)] of western Anatolia volcanism clearly decreased southward with time becoming zero in the time interval 10–15 Ma. The magmatism experienced a sudden change in the extent of Si saturation after 14 Ma, during late-stage volcanic activity of Afyon volcanic province at around 12 Ma, though there was some coexistence of Si-oversaturated and Si-undersaturated magmas during the whole life of Afyon volcanic province

Antenna Arrays Focused on Broadband Signals, Journal of Telecommunications and Information Technology, 2016, nr 2

Broadband and ultra-wideband signals are increasingly used in modern radio systems. Traditional performance of evaluation antennas operating with narrowband signals are not always adequately reflect the characteristics of broadband antennas, at least in view of the frequency dependence of the antenna pattern. Accounting for broadband signals the antennas becomes important in the low-frequency range of the spectrum. Systems using these types of signals may include control of the atmosphere and measuring its frequency-selective properties in the range meter and decameter wavelengths. Possibility of spatial selection based on focusing of broadband signals in this case promises to implement a number of additional features. Therefore, it is important to evaluate the properties of antennas based on the spectral content of the signal, as well as taking into account the ways of its processing in the receiving equipment. Consideration features of functioning the antenna array, focused on broadband signal is devoted to this article

The RESET project: constructing a European tephra lattice for refined synchronisation of environmental and archaeological events during the last c. 100 ka

This paper introduces the aims and scope of the RESET project (. RESponse of humans to abrupt Environmental Transitions), a programme of research funded by the Natural Environment Research Council (UK) between 2008 and 2013; it also provides the context and rationale for papers included in a special volume of Quaternary Science Reviews that report some of the project's findings. RESET examined the chronological and correlation methods employed to establish causal links between the timing of abrupt environmental transitions (AETs) on the one hand, and of human dispersal and development on the other, with a focus on the Middle and Upper Palaeolithic periods. The period of interest is the Last Glacial cycle and the early Holocene (c. 100-8 ka), during which time a number of pronounced AETs occurred. A long-running topic of debate is the degree to which human history in Europe and the Mediterranean region during the Palaeolithic was shaped by these AETs, but this has proved difficult to assess because of poor dating control. In an attempt to move the science forward, RESET examined the potential that tephra isochrons, and in particular non-visible ash layers (cryptotephras), might offer for synchronising palaeo-records with a greater degree of finesse. New tephrostratigraphical data generated by the project augment previously-established tephra frameworks for the region, and underpin a more evolved tephra 'lattice' that links palaeo-records between Greenland, the European mainland, sub-marine sequences in the Mediterranean and North Africa. The paper also outlines the significance of other contributions to this special volume: collectively, these illustrate how the lattice was constructed, how it links with cognate tephra research in Europe and elsewhere, and how the evidence of tephra isochrons is beginning to challenge long-held views about the impacts of environmental change on humans during the Palaeolithic. © 2015 Elsevier Ltd.RESET was funded through Consortium Grants awarded by the Natural Environment Research Council, UK, to a collaborating team drawn from four institutions: Royal Holloway University of London (grant reference NE/E015905/1), the Natural History Museum, London (NE/E015913/1), Oxford University (NE/E015670/1) and the University of Southampton, including the National Oceanography Centre (NE/01531X/1). The authors also wish to record their deep gratitude to four members of the scientific community who formed a consultative advisory panel during the lifetime of the RESET project: Professor Barbara Wohlfarth (Stockholm University), Professor Jørgen Peder Steffensen (Niels Bohr Institute, Copenhagen), Dr. Martin Street (Romisch-Germanisches Zentralmuseum, Neuwied) and Professor Clive Oppenheimer (Cambridge University). They provided excellent advice at key stages of the work, which we greatly valued. We also thank Jenny Kynaston (Geography Department, Royal Holloway) for construction of several of the figures in this paper, and Debbie Barrett (Elsevier) and Colin Murray Wallace (Editor-in-Chief, QSR) for their considerable assistance in the production of this special volume.Peer Reviewe

JWST Reveals Powerful Feedback from Radio Jets in a Massive Galaxy at z = 4.1

We report observations of a powerful ionized gas outflow in the z = 4.1 luminous radio galaxy TNJ1338-1942 hosting an obscured quasar using the Near Infrared Spectrograph (NIRSpec) on board JWST. We spatially resolve a large-scale (∼15 kpc) outflow and measure outflow rates. The outflowing gas shows velocities exceeding 900 km s−1 and broad line profiles with widths exceeding 1200 km s−1 located at an ∼10 kpc projected distance from the central nucleus. The outflowing nebula spatially overlaps with the brightest radio lobe, indicating that the powerful radio jets are responsible for the outflow kinematics. The gas is possibly ionized by the obscured quasar with a contribution from shocks induced by the jets. The mass outflow rate map shows that the region with the broadest line profiles exhibits the strongest outflow rates. The total mass outflow rate is ∼500 M ⊙ yr−1, and the mass loading factor is ∼1, indicating that a significant part of the gas is displaced outwards by the outflow. Our hypothesis is that the overpressured shocked jet fluid expands laterally to create an expanding ellipsoidal “cocoon” that causes the surrounding gas to accelerate outwards. The total kinetic energy injected by the radio jet is about 3 orders of magnitude larger than the energy in the outflowing ionized gas. This implies that kinetic energy must be transferred inefficiently from the jets to the gas. The bulk of the deposited energy possibly lies in the form of hot X-ray-emitting gas

Winds of change: The nuclear and galaxy-scale outflows and the X-ray variability of 2MASS 0918+2117

Context. In this work, we test feedback propagation models on the test case of 2MASS 0918+2117 (2M0918), a z = 0.149 X-ray variable AGN that shows tentative evidence for nuclear ultra-fast outflows (UFOs) in a 2005 XMM-Newton observation. We also investigate whether UFOs can be related to the observed X-ray variability. Aims. We observed 2M0918 with XMM-Newton and NuSTAR in 2020 to confirm the presence of and characterize the UFOs. We performed a kinematic analysis of the publicly available 2005 SDSS optical spectrum to reveal and measure the properties of galaxy-scale ionized outflows. Furthermore, we constructed 20-year-long light curves of observed flux, line-of-sight column density, and intrinsic accretion rate from the spectra of the first four SRG/eROSITA all-sky surveys and archival observations from Chandra and XMM-Newton. Methods. We detect UFOs with v ~ 0.16c and galaxy-scale ionized outflows with velocities of ~700 km s-1. We also find that the drastic X-ray variability (factors > 10) can be explained in terms of variable obscuration and variable intrinsic luminosity. Results. Comparing the energetics of the two outflow phases, 2M0918 is consistent with momentum-driven wind propagation. 2M0918 expands the sample of AGN with both UFOs and ionized gas winds from 5 to 6 and brings the sample of AGN hosting multiscale outflows to 19, contributing to a clearer picture of feedback physics. From the variations in accretion rate, column density, and ionization level of the obscuring medium, we propose a scenario that connects obscurers, an accretion enhancement, and the emergence of UFOs

Trafficking Defect and Proteasomal Degradation Contribute to the Phenotype of a Novel KCNH2 Long QT Syndrome Mutation

The Kv11.1 (hERG) K+ channel plays a fundamental role in cardiac repolarization. Missense mutations in KCNH2, the gene encoding Kv11.1, cause long QT syndrome (LQTS) and frequently cause channel trafficking-deficiencies. This study characterized the properties of a novel KCNH2 mutation discovered in a LQT2 patient resuscitated from a ventricular fibrillation arrest. Proband genotyping was performed by SSCP and DNA sequencing. The electrophysiological and biochemical properties of the mutant channel were investigated after expression in HEK293 cells. The proband manifested a QTc of 554 ms prior to electrolyte normalization. Mutation analysis revealed an autosomal dominant frameshift mutation at proline 1086 (P1086fs+32X; 3256InsG). Co-immunoprecipitation demonstrated that wild-type Kv11.1 and mutant channels coassemble. Western blot showed that the mutation did not produce mature complex-glycosylated Kv11.1 channels and coexpression resulted in reduced channel maturation. Electrophysiological recordings revealed mutant channel peak currents to be similar to untransfected cells. Co-expression of channels in a 1∶1 ratio demonstrated dominant negative suppression of peak Kv11.1 currents. Immunocytochemistry confirmed that mutant channels were not present at the plasma membrane. Mutant channel trafficking rescue was attempted by incubation at reduced temperature or with the pharmacological agents E-4031. These treatments did not significantly increase peak mutant currents or induce the formation of mature complex-glycosylated channels. The proteasomal inhibitor lactacystin increased the protein levels of the mutant channels demonstrating proteasomal degradation, but failed to induce mutant Kv11.1 protein trafficking. Our study demonstrates a novel dominant-negative Kv11.1 mutation, which results in degraded non-functional channels leading to a LQT2 phenotype

Transient Receptor Potential (TRP) and Cch1-Yam8 Channels Play Key Roles in the Regulation of Cytoplasmic Ca2+ in Fission Yeast

The regulation of cytoplasmic Ca2+ is crucial for various cellular processes. Here, we examined the cytoplasmic Ca2+ levels in living fission yeast cells by a highly sensitive bioluminescence resonance energy transfer-based assay using GFP-aequorin fusion protein linked by 19 amino acid. We monitored the cytoplasmic Ca2+ level and its change caused by extracellular stimulants such as CaCl2 or NaCl plus FK506 (calcineurin inhibitor). We found that the extracellularly added Ca2+ caused a dose-dependent increase in the cytoplasmic Ca2+ level and resulted in a burst-like peak. The overexpression of two transient receptor potential (TRP) channel homologues, Trp1322 or Pkd2, markedly enhanced this response. Interestingly, the burst-like peak upon TRP overexpression was completely abolished by gene deletion of calcineurin and was dramatically decreased by gene deletion of Prz1, a downstream transcription factor activated by calcineurin. Furthermore, 1 hour treatment with FK506 failed to suppress the burst-like peak. These results suggest that the burst-like Ca2+ peak is dependent on the transcriptional activity of Prz1, but not on the direct TRP dephosphorylation. We also found that extracellularly added NaCl plus FK506 caused a synergistic cytosolic Ca2+ increase that is dependent on the inhibition of calcineurin activity, but not on the inhibition of Prz1. The synergistic Ca2+ increase is abolished by the addition of the Ca2+ chelator BAPTA into the media, and is also abolished by deletion of the gene encoding a subunit of the Cch1-Yam8 Ca2+ channel complex, indicating that the synergistic increase is caused by the Ca2+ influx from the extracellular medium via the Cch1-Yam8 complex. Furthermore, deletion of Pmk1 MAPK abolished the Ca2+ influx, and overexpression of the constitutively active Pek1 MAPKK enhanced the influx. These results suggest that Pmk1 MAPK and calcineurin positively and negatively regulate the Cch1-Yam8 complex, respectively, via modulating the balance between phosphorylation and dyphosphorylation state

Trafficking Defect and Proteasomal Degradation Contribute to the Phenotype of a Novel KCNH2 Long QT Syndrome Mutation

The Kv11.1 (hERG) K+ channel plays a fundamental role in cardiac repolarization. Missense mutations in KCNH2, the gene encoding Kv11.1, cause long QT syndrome (LQTS) and frequently cause channel trafficking-deficiencies. This study characterized the properties of a novel KCNH2 mutation discovered in a LQT2 patient resuscitated from a ventricular fibrillation arrest. Proband genotyping was performed by SSCP and DNA sequencing. The electrophysiological and biochemical properties of the mutant channel were investigated after expression in HEK293 cells. The proband manifested a QTc of 554 ms prior to electrolyte normalization. Mutation analysis revealed an autosomal dominant frameshift mutation at proline 1086 (P1086fs+32X; 3256InsG). Co-immunoprecipitation demonstrated that wild-type Kv11.1 and mutant channels coassemble. Western blot showed that the mutation did not produce mature complex-glycosylated Kv11.1 channels and coexpression resulted in reduced channel maturation. Electrophysiological recordings revealed mutant channel peak currents to be similar to untransfected cells. Co-expression of channels in a 1∶1 ratio demonstrated dominant negative suppression of peak Kv11.1 currents. Immunocytochemistry confirmed that mutant channels were not present at the plasma membrane. Mutant channel trafficking rescue was attempted by incubation at reduced temperature or with the pharmacological agents E-4031. These treatments did not significantly increase peak mutant currents or induce the formation of mature complex-glycosylated channels. The proteasomal inhibitor lactacystin increased the protein levels of the mutant channels demonstrating proteasomal degradation, but failed to induce mutant Kv11.1 protein trafficking. Our study demonstrates a novel dominant-negative Kv11.1 mutation, which results in degraded non-functional channels leading to a LQT2 phenotype

The SRG/eROSITA all-sky survey: First X-ray catalogues and data release of the western Galactic hemisphere

The eROSITA telescope array aboard the Spektrum Roentgen Gamma (SRG) satellite began surveying the sky in December 2019, with the aim of producing all-sky X-ray source lists and sky maps of an unprecedented depth. Here we present catalogues of both point-like and extended sources using the data acquired in the first six months of survey operations (eRASS1; completed June 2020) over the half sky whose proprietary data rights lie with the German eROSITA Consortium. We describe the observation process, the data analysis pipelines, and the characteristics of the X-ray sources. With nearly 930 000 entries detected in the most sensitive 0.2- 2.3 keV energy range, the eRASS1 main catalogue presented here increases the number of known X-ray sources in the published literature by more than 60%, and provides a comprehensive inventory of all classes of X-ray celestial objects, covering a wide range of physical processes. A smaller catalogue of 5466 sources detected in the less sensitive but harder 2.3- 5 keV band is the result of the first true imaging survey of the entire sky above 2 keV. We present methods to identify and flag potential spurious sources in the catalogues, which we applied for this work, and we tested and validated the astrometric accuracy via cross-comparison with other X-ray and multi-wavelength catalogues. We show that the number counts of X-ray sources in eRASSl are consistent with those derived over narrower fields by past X-ray surveys of a similar depth, and we explore the number counts variation as a function of the location in the sky. Adopting a uniform all-sky flux limit (at 50% completeness) of F05- 2 keV > 5 × 10-14 erg s-1 cm-2, we estimate that the eROSITA all-sky survey resolves into individual sources about 20% of the cosmic X-ray background in the 1- 2 keV range. The catalogues presented here form part of the first data release (DR1) of the SRG/eROSITA all-sky survey. Beyond the X-ray catalogues, DR1 contains all detected and calibrated event files, source products (light curves and spectra), and all-sky maps. Illustrative examples of these are provided

The average soft X-ray spectra of eROSITA active galactic nuclei

Context. Active galactic nuclei (AGN) stand as extreme X-ray emitters where disk-corona interplay shapes their spectral energy distribution. The soft X-ray excess, a unique feature of AGN in the 0.5 − 2.0 keV, encodes critical information on the “warm corona” structure bridging the disk and hot corona. However, the systematic evolution of this feature with fundamental accretion parameters in large AGN samples – particularly those studied through the spectral stacking technique – remains observationally unconstrained.Aims. The eROSITA All-Sky Survey (eRASS:5) provides an unprecedented sample to statistically map AGN spectral properties. We present a multiwavelength investigation of how the average AGN X-ray spectra evolve with accretion parameters (αox, LUV, λEdd, MBH), and we explore the disk-corona connection by further combining stacked UV data.Methods. We have developed Xstack, a novel X-ray spectral stacking code that consistently stacks rest-frame pulse invariant (PI) spectra and associated responses using optimized response weighting to preserve spectral shapes. With Xstack, we stacked 17 929 AGNs (“spec-z” sample, total exposure ∼23 Ms) with similar X-ray loudness, αox, and UV luminosity, LUV, and 4159 AGNs (“BH-mass” sample, ∼3 Ms) with similar Eddington ratios, λEdd, and black hole masses, MBH. We analyzed the resulting stacked X-ray spectra with a phenomenological model for both samples. We further fit the stacked optical-UV X-ray SED with the physical AGNSED model on a 3 × 3 MBH – λEdd grid.Results. We observed that the soft excess strength rises strongly with increasing αox and λEdd binning (by a factor of five), while the hard X-ray spectral shape remains largely unchanged, consistent with the interpretation that soft excess is primarily driven by the warm corona rather than reflection. The trends are weaker with LUV binning and reversed for MBH binning. The analysis of the optical-UV X-ray SEDs with AGNSED revealed that the warm corona radius (in units of Rg) generally increases with λEdd and decreases with MBH, or equivalently the disk-to-warm-corona transition consistently occurs near ∼1  ×  104 K. The hot corona contracts with λEdd, and the radius remains independent of MBH, aligning with disk evaporation predictions.Conclusions. The soft excess is likely warm-corona dominated, with the disk-to-warm-corona transition potentially linked to hydrogen ionization instability at ∼1  ×  104 K, which is consistent with previous work utilizing eFEDS-HSC stacked data. Our work highlights the power of spectral stacking for revealing the AGN disk-corona connection