MicroPET imaging of 5-HT1A receptors in rat brain: a test-retest [18F]MPPF study

Purpose: Earlier studies have shown that positron emission tomography (PET) imaging with the radioligand [18F]MPPF allows for measuring the binding potential of serotonin 5-hydroxytryptamine1A (5-HT1A) receptors in different regions of animal and human brain, including that of 5-HT1A autoreceptors in the raphe nuclei. In the present study, we sought to determine if such data could be obtained in rat, with a microPET (R4, Concorde Microsystems). Methods: Scans from isoflurane-anaesthetised rats (n = 18, including six test-retest) were co-registered with magnetic resonance imaging data, and binding potential, blood to plasma ratio and radiotracer efflux were estimated according to a simplified reference tissue model. Results: Values of binding potential for hippocampus (1.2), entorhinal cortex (1.1), septum (1.1), medial prefrontal cortex (1.0), amygdala (0.8), raphe nuclei (0.6), paraventricular hypothalamic nucleus (0.5) and raphe obscurus (0.5) were comparable to those previously measured with PET in cats, non-human primates or humans. Test-retest variability was in the order of 10% in the larger brain regions (hippocampus, medial prefrontal and entorhinal cortex) and less than 20% in small nuclei such as the septum and the paraventricular hypothalamic, basolateral amygdaloid and raphe nuclei. Conclusions: MicroPET brain imaging of 5-HT1A receptors with [18F]MPPF thus represents a promising avenue for investigating 5-HT1A receptor function in ra

MicroPET imaging of 5-HT1A receptors in rat brain: a test-retest [F-18]MPPF study

Purpose Earlier studies have shown that positron emission tomography (PET) imaging with the radioligand [F-18] MPPF allows for measuring the binding potential of serotonin 5-hydroxytryptamine(1A) (5-HT1A) receptors in different regions of animal and human brain, including that of 5-HT1A autoreceptors in the raphe nuclei. In the present study, we sought to determine if such data could be obtained in rat, with a microPET (R4, Concorde Microsystems)

Highlighting the versatility of the tracerlab synthesis modules. Part 1: fully automated production of [ 18 F]labelled radiopharmaceuticals using a Tracerlab FX FN

The field of radiochemistry is moving toward exclusive use of automated synthesis modules for production of clinical radiopharmaceutical doses. Such a move comes with many advantages, but also presents radiochemists with the challenge of re‐configuring synthesis modules for production of radiopharmaceuticals that require nonconventional radiochemistry while maintaining full automation. This review showcases the versatility of the Tracerlab FX FN synthesis module by presenting simple, fully automated methods for producing [ 18 F]FLT, [ 18 F]FAZA, [ 18 F]MPPF, [ 18 F]FEOBV, [ 18 F]sodium fluoride, [ 18 F]fluorocholine and [ 18 F]SFB. Copyright © 2011 John Wiley & Sons, Ltd. The versatility of the Tracerlab‐FX FN synthesis module is showcased through preparation of a range of [ 18 F]labeled radiopharmaceuticals. Each radiopharmaceutical is prepared using a unique radiochemical strategy and all reported syntheses are fully automated. Copyright © 2011 John Wiley & Sons, Ltd.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/86935/1/1865_ftp.pd

Nuclear Medicine Imaging Tracers for Neurology

Tracers to investigate neurological disorders with positron emission tomography (PET) or single-photon emission computed tomography (SPECT) have found many applications. Several molecular targets can be studied in the human brain in vivo, both in health and disease. Initially, most attention was given to tracers for translocator protein (TSPO), deposition of beta-amyloid, and the dopaminergic system. Many clinical studies have been published with application of a variety of tracers for these targets. During the past few years, more tracers have reached the stage of human studies such as imaging agents for tau protein, P2X7 receptor, SV2A receptor, and the cholinergic system. Other targets of interest that have been studied in man to a lesser extent are N-methyl-d-aspartic acid (NMDA), serotonergic, adenosine, gamma-aminobutyric acid (GABA), sigma, opioid, and metabotropic glutamate subtype 5 (mGlu5) receptors. In addition, several transporter systems have received a great deal of attention. Many tracers for new molecular targets are under development and may open new horizons in the future. Most PET tracers for the brain were initially labeled with 11C but were later replaced by 18F-labeled analogs, since this radionuclide enables longer scanning protocols, dissemination to other hospitals, and commercialization. This initial chapter will highlight PET tracers that have already reached the state of human application.</p

Bodies in Marivaux’s Works : generic, Moral and Empiricist Approaches

Si Marivaux est connu pour son analyse des sentiments et de la métaphysique du coeur, ses personnages, dotés d’une vie intérieure complexe, ont aussi un corps. Afin de proposer une lecture méthodique et transversale du corps, nous prenons comme corpus de départ l’intégralité des oeuvres de Marivaux, sans distinction de genre ni d’époque. Il en ressort qu’il n’y a pas un corps marivaudien, unique et systématique qui traverserait toutes les oeuvres marivaudiennes sans être affecté par le contexte de production, mais des corps qui correspondent à des époques et à des choix d’écriture. Pour établir ces ensembles génériques et chronologiques, nous nous intéressons aux particularités des différents genres littéraires (roman, théâtre, périodique, travestissement burlesque etc.) pratiqués par Marivaux et au contexte de production des oeuvres marivaudiennes (la seconde Querelle des Anciens et des Modernes, le renouvellement de l’Académie royale des sciences et le contexte philosophique de la diffusion de la théorie empiriste de Locke).If Marivaux is primarily renowned for his in-depth analysis of feelings and his metaphysics of the heart, his characters, who have a complex inner life, also have a body. In order to offer a methodical and horizontal reading of the body, we focus on all of Marivaux’s works, without distinction of literary genre or period. There appears to be no standardized or systematic representation of the body spanning all Marivaux’s works without being influenced by the context of production, but rather, various bodies whose characteristics are informed by periods and choices of writing. In order to define these generic and chronological groupings, we explore the features of the different literary genres (novel, theater, periodical, burlesque travesty, etc.) used by Marivaux and the context of his works (Homeric Warfare, the renewal of the Royal Academy of Sciences, and the growing influence of Locke’s theory of empiricism)

Données nouvelles sur les innervations cholinergiques de l'hippocampe et du néostriatum et sur leur ultrastructure au cours du développement

Thèse numérisée par la Direction des bibliothèques de l'Université de Montréal

UN NOUVEAU MERENDERA D\u27ANATOLIE (avec gravure dans le texte)

Volume: 8Start Page: 248End Page: 25

For Mama : La Mamma

https://digitalcommons.library.umaine.edu/mmb-vp-copyright/6200/thumbnail.jp