Two-stage Kondo effect in a four-electron artificial atom

An artificial atom with four electrons is driven through a singlet-triplet transition by varying the confining potential. In the triplet, a Kondo peak with a narrow dip at drain-source voltage V_ds=0 is observed. The low energy scale V_ds* characterizing the dip is consistent with predictions for the two-stage Kondo effect. The phenomenon is studied as a function of temperature T and magnetic field B, parallel to the two-dimensional electron gas. The low energy scales T* and B* are extracted from the behavior of the zero-bias conductance and are compared to the low energy scale V_ds* obtained from the differential conductance. Good agreement is found between kT* and |g|muB*, but eV_ds* is larger, perhaps because of nonequilibrium effects.Comment: 7 pages, 7 figures. Added labels on Fig. 3f and one referenc

A Nano-Mgo and Ionic Liquid-Catalyzed ‘Green’ Synthesis Protocol for the Development of Adamantyl-Imidazolo-Thiadiazoles as Anti-Tuberculosis Agents Targeting Sterol 14α-Demethylase (CYP51)

In this work, we describe the ‘green’ synthesis of novel 6-(adamantan-1-yl)-2-substitutedimidazo[2,1-b][1,3,4]thiadiazoles (AITs) by ring formation reactions using 1-(adamantan-1-yl)-2-bromoethanone and 5-alkyl/aryl-2-amino1,3,4-thiadiazoles on a nano material base inionic liquid media. Given the established activity of imidazothiadiazoles against M. tuberculosis,we next examined the anti-TB activity of AITs against the H37Rv strain using Alamarblue assay. Among the tested compounds 6-(adamantan-1-yl)-2-(4-methoxyphenyl)imidazo[2,1-b][1,3,4]thiadiazole (3f) showed potent inhibitory activity towards M. tuberculosis with an MIC value of 8.5 μM. The inhibitory effect of this molecule against M. tuberculosis was comparable to the standard drugs such as Pyrazinamide, Streptomycin, and Ciprofloxacin drugs. Mechanistically, an in silico analysis predicted sterol 14α-demethylase (CYP51)as the likely target and experimental activity of 3f in this system corroborated the in silico target prediction. In summary, we herein report the synthesis and biological evaluation of novel AITs against M. tuberculosis that likely target CYP51 to induce their antimycobacterial activity

New Fe II energy levels from stellar spectra

The spectra of B-type and early A-type stars show numerous unidentified lines in the whole optical range, especially in the 5100 - 5400 A interval. Because Fe II transitions to high energy levels should be observed in this region, we used semiempirical predicted wavelengths and gf-values of Fe II to identify unknown lines. Semiempirical line data for Fe II computed by Kurucz are used to synthesize the spectrum of the slow-rotating, Fe-overabundant CP star HR 6000. We determined a total of 109 new 4f levels for Fe II with energies ranging from 122324 cm^-1 to 128110 cm^-1. They belong to the Fe II subconfigurations 3d^6(^3P)4f (10 levels), 3d^6(^3H)4f (36 levels), 3d^6(^3F)4f (37 levels), and 3d^6(^3G)4f (26 levels). We also found 14 even levels from 4d (3 levels), 5d (7 levels), and 6d (4 levels) configurations. The new levels have allowed us to identify more than 50% of the previously unidentified lines of HR 6000 in the wavelength region 3800-8000 A. Tables listing the new energy levels are given in the paper; tables listing the spectral lines with loggf>/=-1.5 that are transitions to the 4f energy levels are given in the Online Material. These new levels produce 18000 lines throughout the spectrum from the ultraviolet to the infrared.Comment: Paper accepted by A&A for publicatio

The retroviral restriction factor TRIM5α

Retroviruses are obligate intracellular parasites that have coevolved with their hosts for millions of years. It is therefore not surprising that retroviruses take advantage of numerous host factors during their life cycle. In addition to positive cellular factors that are of use to the virus, host cells have also evolved intracellular proteins to antagonize the retroviral replication cycle. Such inhibitory cellular factors have been called retroviral restriction factors. Recently, several such restriction factors have been cloned, including Friend virus susceptibility factor 1, apolipoprotein B mRNA-editing enzyme catalytic proteins 3F and 3G, and ZAP. Here, we review the explosion of publications from the past 2 years concerning TRIM5, a host factor that potently inhibits HIV-1 and other retroviruse

Spectroscopy of q3qˉ3\rm{q}^3\bar{\rm{q}}^3-States in Quark Model and Baryon-Antibaryon Enhancements

We study the mass spectrum of the $\rm{q}^3\bar{\rm{q}}^3$ mesons both from the quark model with triquark correlations and from common quark model with colormagnetic interactions and with relative S-waves between quarks. Two cluster configurations $(\rm{q}^3)-(\bar{\rm{q}}^3)$ and $(\rm{q}^2\bar{\rm{q}})-(\rm{q}\bar{\rm{q}}^2)$ are considered. In the spectrum we find rather stable states which have the same quantum number with particle resonances which are corresponding to the $p\bar{p}$ enhancement, $p\bar{\Lambda}$ enhancement and $\Lambda\bar{\Lambda}$ enhancement with spin-$\mathbf{0}$ or $\mathbf{1}$. This imply these enhancements are NOT experimental artifacts. The color-spin-flavor structures of $p\bar{p}$, $p\bar{\Lambda}$, and $\Lambda\bar{\Lambda}$ enhancements are revealed. The existence of spin-$\mathbf{1}$ $\Lambda\bar{\Lambda}, p\bar{\Lambda}, p\bar{p}$ enhancements is predicted.Comment: 45 pages, 5 figure

Decisive Markov Chains

We consider qualitative and quantitative verification problems for infinite-state Markov chains. We call a Markov chain decisive w.r.t. a given set of target states F if it almost certainly eventually reaches either F or a state from which F can no longer be reached. While all finite Markov chains are trivially decisive (for every set F), this also holds for many classes of infinite Markov chains. Infinite Markov chains which contain a finite attractor are decisive w.r.t. every set F. In particular, this holds for probabilistic lossy channel systems (PLCS). Furthermore, all globally coarse Markov chains are decisive. This class includes probabilistic vector addition systems (PVASS) and probabilistic noisy Turing machines (PNTM). We consider both safety and liveness problems for decisive Markov chains, i.e., the probabilities that a given set of states F is eventually reached or reached infinitely often, respectively. 1. We express the qualitative problems in abstract terms for decisive Markov chains, and show an almost complete picture of its decidability for PLCS, PVASS and PNTM. 2. We also show that the path enumeration algorithm of Iyer and Narasimha terminates for decisive Markov chains and can thus be used to solve the approximate quantitative safety problem. A modified variant of this algorithm solves the approximate quantitative liveness problem. 3. Finally, we show that the exact probability of (repeatedly) reaching F cannot be effectively expressed (in a uniform way) in Tarski-algebra for either PLCS, PVASS or (P)NTM.Comment: 32 pages, 0 figure

Energy levels, radiative rates, and lifetimes for transitions in W LVIII

Energy levels and radiative rates are reported for transitions in Cl-like W LVIII. Configuration interaction (CI) has been included among 44 configurations (generating 4978 levels) over a wide energy range up to 363 Ryd, and the general-purpose relativistic atomic structure package ({\sc grasp}) adopted for the calculations. Since no other results of comparable complexity are available, calculations have also been performed with the flexible atomic code ({\sc fac}), which help in assessing the accuracy of our results. Energies are listed for the lowest 400 levels (with energies up to $\sim$ 98 Ryd), which mainly belong to the 3s$^2$3p$^5$, 3s3p$^6$, 3s$^2$3p$^4$3d, 3s$^2$3p$^3$3d$^2$, 3s3p$^4$3d$^2$, 3s$^2$3p$^2$3d$^3$, and 3p$^6$3d configurations, and radiative rates are provided for four types of transitions, i.e. E1, E2, M1, and M2. Our energy levels are assessed to be accurate to better than 0.5%, whereas radiative rates (and lifetimes) should be accurate to better than 20% for a majority of the strong transitions.Comment: About 12p of Text and 3 Tables which will be published in ADNDT (2014

Octet Baryon Masses in Partially Quenched Chiral Perturbation Theory

The mass spectrum of the lowest lying octet baryons is calculated to next-to-next-to-leading order in heavy baryon chiral perturbation theory and partially quenched heavy baryon chiral perturbation theory. We work in the isospin limit and treat the decuplet baryons as dynamical fields. These results are necessary for extrapolating QCD and partially quenched QCD lattice simulations of the octet baryon masses.Comment: 33 pgs, 4 figs, formatting changes in appendices, new discussion added in tex