Long-Range Autocorrelations of CpG Islands in the Human Genome

In this paper, we use a statistical estimator developed in astrophysics to study the distribution and organization of features of the human genome. Using the human reference sequence we quantify the global distribution of CpG islands (CGI) in each chromosome and demonstrate that the organization of the CGI across a chromosome is non-random, exhibits surprisingly long range correlations (10 Mb) and varies significantly among chromosomes. These correlations of CGI summarize functional properties of the genome that are not captured when considering variation in any particular separate (and local) feature. The demonstration of the proposed methods to quantify the organization of CGI in the human genome forms the basis of future studies. The most illuminating of these will assess the potential impact on phenotypic variation of inter-individual variation in the organization of the functional features of the genome within and among chromosomes, and among individuals for particular chromosomes

Characterization of high-voltage IGBT module degradations under PWM power cycling test at high ambient temperature

International audienc

A functional approximation for the M/G/1/N queue

This paper presents a new approach to the functional approximation of the M/G/1/N built on a Taylor series approach. Specifically, we establish an approximative expression for the remainder term of the Taylor series that can be computed in an efficient manner. As we will illustrate with numerical examples, the resulting Taylor series approximation turns out to be of practical value. © 2012 The Author(s)

Représentations sociales et marketing social : Efficacité des campagnes de sensibilisation sur la représentation des politiques publiques ?

International audienc