Conclusions from CDF Results on CP Violation in D^0 \to \pi^+\pi^-, K^+K^- and Future Tasks

Within the Standard Model (SM) one predicts both direct and indirect CP violation in D^0 \to \pi^+\pi^-, K^+K^- transitions, although the effects are tiny: Indirect CP asymmetry cannot exceed O(10^{-4}), probably even O(10^{-5}); direct effects are estimated at not larger than 10^{-4}. At B factories direct and indirect asymmetries have been studied with /\tau_{D^0} ~ 1; no CP asymmetry was found with an upper bound of about 1%. CDF has shown intriguing data on CP violation in D^0 \to \pi^+\pi^- [K^+K^-] with /\tau_{D^0} ~ 2.4 [2.65]. Also, CDF has not seen any CP violation. For direct CP asymmetry, CDF has a sensitivity similar to the combination of the B factories, yet for indirect CP violation it yields a significantly smaller sensitivity of a_{cp}^{ind}=(-0.01 +- 0.06_{stat} +- 0.05_{syst})% due to it being based on longer decay times. New Physics models (NP) like Little Higgs Models with T-Parity (LHT) can produce an indirect CP asymmetry up to 1%; CDF's findings thus cover the upper range of realistic NP predictions ~ 0.1 - 1%. One hopes that LHCb and a Super-Flavour Factory will probe the lower range down to ~0.01%. Such non-ad-hoc NP like LHT cannot enhance direct CP violation significantly over the SM level in D^0 \to \pi^+\pi^-, K^+K^- and D^{\pm} \to \pi^{\pm}K^+K^- transitions, but others might well do so.Comment: 11 pages, 1 figure. V2 has minor corrections and corresponds to the published versio

Investigating the impact of changes in iteration-likelihoods on design process performance

Research on changes in design has mainly focused on the product domain, which is the manifestation of the design process. This article investigates changes in the process domain, which describes the execution of coordinated and concurrent design activities through interdisciplinary teams. More specifically, this article focuses on changes in the iterative behavior of activities as one of the key levers determining the performance of complex concurrent design processes. In activity network–based models of design processes, the occurrence of such behavior is often expressed probabilistically through iteration-likelihoods. First, the impact of iteration-likelihood changes on the effort and duration of both individual activities and the overall design process is examined through stochastic analysis. Consequently, a method for the investigation of such changes is developed, which grounds on an experimental approach using Monte Carlo simulation of activity network–based process models. The method is applied to the design process of a high-speed machining device for the manufacturing of planetary-ball-bearing housings. This analysis results in a two-dimensional criticality ranking of potential iteration-likelihood changes and in the identification of the most affected individual activities. The article concludes with managerial implications for process planning and improvement and discusses which design activities need to be targeted by project management to prevent and react to critical iteration-likelihood changes. This is the author accepted manuscript. The final version is available from SAGE via http://dx.doi.org/10.1177/1063293X1558820

Symbiosis between the TRECVid benchmark and video libraries at the Netherlands Institute for Sound and Vision

Audiovisual archives are investing in large-scale digitisation efforts of their analogue holdings and, in parallel, ingesting an ever-increasing amount of born- digital files in their digital storage facilities. Digitisation opens up new access paradigms and boosted re-use of audiovisual content. Query-log analyses show the shortcomings of manual annotation, therefore archives are complementing these annotations by developing novel search engines that automatically extract information from both audio and the visual tracks. Over the past few years, the TRECVid benchmark has developed a novel relationship with the Netherlands Institute of Sound and Vision (NISV) which goes beyond the NISV just providing data and use cases to TRECVid. Prototype and demonstrator systems developed as part of TRECVid are set to become a key driver in improving the quality of search engines at the NISV and will ultimately help other audiovisual archives to offer more efficient and more fine-grained access to their collections. This paper reports the experiences of NISV in leveraging the activities of the TRECVid benchmark

Heavy-to-light baryonic form factors at large recoil

We analyze heavy-to-light baryonic form factors at large recoil and derive the scaling behavior of these form factors in the heavy quark limit. It is shown that only one universal form factor is needed to parameterize Lambda_b to p and Lambda_b to Lambda matrix elements in the large recoil limit of light baryons, while hadronic matrix elements of Lambda_b to Sigma transition vanish in the large energy limit of Sigma baryon due to the space-time parity symmetry. The scaling law of the soft form factor eta(P^{\prime} \cdot v), P^{\prime} and v being the momentum of nucleon and the velocity of Lambda_b baryon, responsible for Lambda_b to p transitions is also derived using the nucleon distribution amplitudes in leading conformal spin. In particular, we verify that this scaling behavior is in full agreement with that from light-cone sum rule approach in the heavy-quark limit. With these form factors, we further investigate the Lambda baryon polarization asymmetry alpha in Lambda_b to Lambda gamma and the forward-backward asymmetry A_{FB} in Lambda_b to Lambda l^{+} l^{-}. Both two observables (alpha and A_{FB}) are independent of hadronic form factors in leading power of 1/m_b and in leading order of alpha_s. We also extend the analysis of hadronic matrix elements for Omega_b to Omega transitions to rare Omega_b to Omega gamma and Omega_b to Omega l^{+} l^{-} decays and find that radiative Omega_b to Omega gamma decay is probably the most promising FCNC b to s radiative baryonic decay channel. In addition, it is interesting to notice that the zero-point of forward-backward asymmetry of Omega_b to Omega l^{+} l^{-} is the same as the one for Lambda_b to Lambda l^{+} l^{-} to leading order accuracy provided that the form factors \bar{\zeta}_i (i=3, 4, 5) are numerically as small as indicated from the quark model.Comment: 19 page

Complement C3 variant and the risk of age-related macular degeneration

Background: Age-related macular degeneration is the most common cause of blindness in Western populations. Susceptibility is influenced by age and by genetic and environmental factors. Complement activation is implicated in the pathogenesis.Methods: We tested for an association between age-related macular degeneration and 13 single-nucleotide polymorphisms (SNPs) spanning the complement genes C3 and C5 in case subjects and control subjects from the southeastern region of England. All subjects were examined by an ophthalmologist and had independent grading of fundus photographs to confirm their disease status. To test for replication of the most significant findings, we genotyped a set of Scottish cases and controls.Results: The common functional polymorphism rs2230199 (Arg80Gly) in the C3 gene, corresponding to the electrophoretic variants C3S (slow) and C3F (fast), was strongly associated with age-related macular degeneration in both the English group (603 cases and 350 controls, P=5.9 x 10(sup -5)) and the Scottish group (244 cases and 351 controls, P=5.0 x 10(sup -5)). The odds ratio for age-related macular degeneration in C3 S/F heterozygotes as compared with S/S homozygotes was 1.7 (95% confidence interval [CI], 1.3 to 2.1); for F/F homozygotes, the odds ratio was 2.6 (95% CI, 1.6 to 4.1). The estimated population attributable risk for C3F was 22%.Conclusions: Complement C3 is important in the pathogenesis of age-related macular degeneration. This finding further underscores the influence of the complement pathway in the pathogenesis of this disease