Comparison of Efficiencies of Neurological Physical Examination, Neurothesiometer and PainDETECT Questionnaire in Diagnosing Diabetic Neuropathy

Objective: To compare the efficacies of neurological physical examination, neurothesiometer and PainDETECT questionnaire in diagnosing diabetic neuropathy. Study Design: Prospective cross-sectional Place and Duration of Study: Department of General Medicine, Nishtar Hospital Multan, Pakistan from 1st December 2018 to 10th March 2019. Materials and Methods: One hundred and four patients of both type 1 and type 2 diabetes visiting the outdoor department were included in this study. They were assessed by lab results of glycosylated hemoglobin, fasting and random blood sugar levels and neurological physical examination. Results: The physical examination with Michigan Neuropathy Screening instrument showed that around 29 of the patients were having established neuropathy. The PainDETECT questionnaire on the other hand showed about 42 patients having a definitive neuropathy while the neurothesiometer showed that 79 of the total patients had varying degrees of neuropathy. Conclusion: The neurothesiometer is a better diagnostic tool for diagnosing diabetic neuropathy in patients

Dissipation enhanced vibrational sensing in an olfactory molecular switch

Motivated by a proposed olfactory mechanism based on a vibrationally-activated molecular switch, we study electron transport within a donor-acceptor pair that is coupled to a vibrational mode and embedded in a surrounding environment. We derive a polaron master equation with which we study the dynamics of both the electronic and vibrational degrees of freedom beyond previously employed semiclassical (Marcus-Jortner) rate analyses. We show: (i) that in the absence of explicit dissipation of the vibrational mode, the semiclassical approach is generally unable to capture the dynamics predicted by our master equation due to both its assumption of one-way (exponential) electron transfer from donor to acceptor and its neglect of the spectral details of the environment; (ii) that by additionally allowing strong dissipation to act on the odorant vibrational mode we can recover exponential electron transfer, though typically at a rate that differs from that given by the Marcus-Jortner expression; (iii) that the ability of the molecular switch to discriminate between the presence and absence of the odorant, and its sensitivity to the odorant vibrational frequency, are enhanced significantly in this strong dissipation regime, when compared to the case without mode dissipation; and (iv) that details of the environment absent from previous Marcus-Jortner analyses can also dramatically alter the sensitivity of the molecular switch, in particular allowing its frequency resolution to be improved. Our results thus demonstrate the constructive role dissipation can play in facilitating sensitive and selective operation in molecular switch devices, as well as the inadequacy of semiclassical rate equations in analysing such behaviour over a wide range of parameters.Comment: 12 pages, 6 figures, close to published version, comments welcom

Tunneling of a composite particle: Effects of intrinsic structure

We consider simple models of tunneling of an object with intrinsic degrees of freedom. This important problem was not extensively studied until now, in spite of numerous applications in various areas of physics and astrophysics. We show possibilities of enhancement for the probability of tunneling due to the presence of intrinsic degrees of freedom split by weak external fields or by polarizability of the slow composite object.Comment: 6 pages, 3 figures, version to be published in Journal of Physics

Cerebral fungal infection with mycotic aneurysm of basilar artery and subarachnoid haemorrhage

A 28-year-old Pakistani man was admitted with unresolved severe headaches for the past four weeks. Magnetic resonance (MR) imaging and MR angiography showed an enhancing mass in the sphenoid sinus, bilateral cerebellar infarcts and aneurysmal dilatation of the basilar artery. The differential diagnosis included fungal infection versus neoplastic lesion. The scrappings taken through the endoscope from the sphenoid sinus were initially negative for fungal infection. However, the second biopsy, done after putting him on antifungal, itraconazole 200 mg twice daily, revealed the presence of a fungal infection (aspergillosis). MR imaging revealed extension of the fungal infection from the sphenoid sinus into the clivus, and then intracranially. Imaging also revealed aneurysmal dilatation of the basilar artery and infarctions in the cerebellum and subarachnoid haemorrhage. Despite aggressive antifungal treatment, the Patient died after 29 days. This case report describes the probable mechanism of fungal mycotic aneurysmal vascular dilatation and growth. It also points to the need for a rapid diagnosis of potential cases and an aggressive treatment approach of confirmed cases of fungal infections of the central nervous system

Assessing structural damages of a heritage building

This paper presents an intensive structural survey work on an industrial heritage structure. This study identified the decay mechanism and material characteristics of the historic structure, including material homogeneity, material strength, structural failures with crack pattern, and deteriorated surface. The damages in the building include decay in timber and stones, dampness problem and incompatible structural assemblage. The lack of a long-term maintenance is one of the potential causes which aggravate the decay mechanism. The findings permitted to appraise the structural safety and to depict some recommendations for better treatment of the structural cracks to restore this industrial heritage structure. These proposals would be useful in the conservation management plan of the city

Covers of acts over monoids II

In 1981 Edgar Enochs conjectured that every module has a flat cover and finally proved this in 2001. Since then a great deal of effort has been spent on studying different types of covers, for example injective and torsion free covers. In 2008, Mahmoudi and Renshaw initiated the study of flat covers of acts over monoids but their definition of cover was slightly different from that of Enochs. Recently, Bailey and Renshaw produced some preliminary results on the `other' type of cover and it is this work that is extended in this paper. We consider free, divisible, torsion free and injective covers and demonstrate that in some cases the results are quite different from the module case

Z7Z_7 Orbifold Models in M-Theory

Among $T^7/\Gamma$ orbifold compactifications of $M$-theory, we examine models containing the particle physics Standard Model in four-dimensional spacetimes, which appear as fixed subspaces of the ten-dimensional spacetimes at each end of the interval, $I^1\simeq S^1/Z_2$, spanning the $11^\text{th}$ dimension. Using the $Z_7$ projection to break the $E_8$ gauge symmetry in each of the four-planes and a limiting relation to corresponding heterotic string compactifications, we discuss the restrictions on the possible resulting gauge field and matter spectra. In particular, some of the states are non-local: they connect two four-dimensional Worlds across the $11^\text{th}$ dimension. We illustrate our programmable calculations of the matter field spectrum, including the anomalous U(1) factor which satisfies a universal Green-Schwarz relation, discuss a Dynkin diagram technique to showcase a model with $SU(3)\times SU(2)\times U(1)^5$ gauge symmetry, and discuss generalizations to higher order orbifolds.Comment: 23 pages, 2 figures, 4 tables; LaTeX 3 time

Rotating Bose gas with hard-core repulsion in a quasi-2D harmonic trap: vortices in BEC

We consider a gas of N(=6, 10, 15) Bose particles with hard-core repulsion, contained in a quasi-2D harmonic trap and subjected to an overall angular velocity $\Omega$ about the z-axis. Exact diagonalization of the $n\times n$ many-body Hamiltonian matrix in given subspaces of the total (quantized) angular momentum L$_{z}$, with $n\sim 10^{5}$(e.g. for L$_{z}$=N=15, n =240782) was carried out using Davidson's algorithm. The many-body variational ground state wavefunction, as also the corresponding energy and the reduced one-particle density-matrix were calculated. With the usual identification of $\Omega$ as the Lagrange multiplier associated with L$_{z}$ for a rotating system, the $L_{z}-\Omega$ phase diagram (or the stability line) was determined that gave a number of critical angular velocities $\Omega_{{\bf c}i}, i=1,2,3,... ,$ at which the ground state angular momentum and the associated condensate fraction undergo abrupt jumps. A number of (total) angular momentum states were found to be stable at successively higher critical angular velocities $\Omega_{{\bf c}i}, \ i=1,2,3,...$for a given N. For$L_{z}>N$, the condensate was strongly depleted. The critical$\Omega_{{\bf c}i}$values, however, decreased with increasing interaction strength as well as the particle number, and were systematically greater than the non-variational Yrast-state values for the single vortex state with L$_{z}$=N. We have also observed that the condensate fraction for the single vortex state (as also for the higher vortex states) did not change significantly even as the 2-body interaction strength was varied over several$(\sim 4)$ orders of magnitude in the moderately to the weakly interacting regime.Comment: Revtex, 11 pages, 1 table as ps file, 4 figures as ps file

Grid enabled data analysis on handheld devices

The requirement for information on portable, handheld devices demands the realization of increasingly complex applications for increasingly small and ubiquitous devices. This trend promotes the migration of technologies that were originally developed for desktop computers to handheld devices. With the onset of grid computing, users of handheld devices should be able to accomplish much more complex tasks, by accessing the processing and storage resources of the grid. This paper describes the development, features, and performance aspects of a grid enabled analysis environment designed for handheld devices. We also describe some differences in the technologies required to run these applications on desktop machines and handheld devices. In addition, we propose a prototype agent-based distributed architecture for carrying out high-speed analysis of physics data on handheld devices