Vitamin D insufficiency and mild cognitive impairment: cross-sectional association

BACKGROUND: Low serum 25-hydroxyvitamin D (25OHD) concentrations have been associated with dementia. The association with mild cognitive impairment (MCI) has not yet been explored. Our aim was to examine the association between vitamin D status and MCI status amongst older community-dwellers with subjective memory complaint.METHODS: Ninety-five non-demented Caucasian community-dwellers with subjective memory complaint (mean, 71.16.4years; 54.7% women) included in the Gait and Alzheimer Interaction Tracking (GAIT) study were categorized into two groups according to Winblad et al. consensus criteria [i.e., subjects with MCI or cognitively healthy individuals (CHI)]. Serum 25OHD concentration was divided into quartiles, the fourth quartile corresponding to the highest 25OHD concentration. The cross-sectional associations between 25OHD concentrations and MCI were modeled using logistic regressions. Age, gender, body mass index, number of comorbidities, education level, Mini-Mental State Examination score, Frontal Assessment Battery score, Geriatric Depression Scale score, creatinine clearance, and season tested were considered as potential confounders. RESULTS: Compared to CHI, patients with MCI (n=43; mean, 71.45.6years; 34.9% women) had lower mean serum 25OHD concentrations (P=0.006) and belonged more often to the lower quartiles compared to the highest quartile (P=0.03). Increased serum 25OHD concentration was associated with a lower risk of MCI [adjusted odds ratio (OR)=0.96, P=0.002]. Accordingly, lower quartiles of 25OHD were positively associated with MCI whilst using the highest quartile as reference (adjusted OR=25.46, P=0.002 for the first quartile; adjusted OR=6.89, P=0.03 for the second quartile; and adjusted OR=10.29, P=0.02 for the third quartile). CONCLUSIONS: Low 25OHD concentrations were associated with MCI status in older non-demented community-dwellers with subjective memory complaint

Motor phenotype of decline in cognitive performance among community-dwellers without dementia: Population-based study and meta-analysis

Background: Decline in cognitive performance is associated with gait deterioration. Our objectives were: 1) to determine, from an original study in older community-dwellers without diagnosis of dementia, which gait parameters, among slower gait speed, higher stride time variability (STV) and Timed Up & Go test (TUG) delta time, were most strongly associated with lower performance in two cognitive domains (i.e., episodic memory and executive function); and 2) to quantitatively synthesize, with a systematic review and meta-analysis, the association between gait performance and cognitive decline (i.e., mild cognitive impairment (MCI) and dementia). Methods: Based on a cross-sectional design, 934 older community-dwellers without dementia (mean6standard deviation, 70.3 64.9years; 52.1% female) were recruited. A score at 5 on the Short Mini-Mental State Examination defined low episodic memory performance. Low executive performance was defined by clock-drawing test errors. STV and gait speed were measured using GAITRite system. TUG delta time was calculated as the difference between the times needed to perform and to imagine the TUG. Then, a systematic Medline search was conducted in November 2013 using the Medical Subject Heading terms "Delirium," "Dementia," "Amnestic," "Cognitive disorders" combined with "Gait" OR "Gait disorders, Neurologic" and "Variability." Findings: A total of 294 (31.5%) participants presented decline in cognitive performance. Higher STV, higher TUG delta time, and slower gait speed were associated with decline in episodic memory and executive performances (all P-values <0.001). The highest magnitude of association was found for higher STV (effect size = -0.74 [95% Confidence Interval (CI): -1.05;- 0.43], among participants combining of decline in episodic memory and in executive performances). Meta-analysis underscored that higher STV represented a gait biomarker in patients with MCI (effect size = 0.48 [95% CI: 0.30;0.65]) and dementia (effect size = 1.06 [95% CI: 0.40;1.72]). Conclusion: Higher STV appears to be a motor phenotype of cognitive decline. © 2014 Beauchet et al

The 6th international conference on envenomation by snakebites and scorpion stings in Africa : a crucial step for the management of envenomation

During the 6th International Conference on Envenomation by Snakebites and Scorpion Stings in Africa held in Abidjan, from 1 to 5 June 2015, the measures for the management of envenomation were discussed and new recommendations were adopted by the participants. The high incidence and severity of this affliction were confirmed by several studies conducted in African countries. The poor availability of antivenom, particularly because of the cost, was also highlighted. Some experiences have been reported, mainly those regarding the financial support of antivenom in Burkina Faso (more than 90 %) and Togo (up to 60 %) or the mandatory reporting of cases in Cameroon. Key recommendations concerned: improvement of epidemiological information based on case collection; training of health workers in the management of envenomation; policy to promote the use of effective and safe antivenom; and antivenom funding by sharing its costs with stakeholders in order to improve antivenom accessibility for low-income patients

Control of the power quality for a DFIG powered by multilevel inverters

This paper treats the modeling, and the control of a wind power system based on a doubly fed induction generator DFIG, the stator is directly connected to the grid, while the rotor is powered by multilevel inverters. In order to get a decoupled system of controlfor an independently transits of active and reactive power, a vector control method based on stator flux orientation SFOC is considered: Direct vector control based on PI controllers. Cascaded H-bridge CHBI multilevel inverters are used in the rotor circuit to study its effect on supply power quality. All simulation models are built in MATLAB/Simulink software. Results and waveforms clearly show the effectiveness of vector control strategy. Finally, performances of the system will tested and compared for each levels of inverter

The relationship between organisational culture and knowledge sharing in the information communication technology firms in Libya

Examining the nature of the relationship between Organisational Culture (OC) and Knowledge Sharing (KS) has been the concern of a number of academic studies. Most of these studies have suggested that different aspects of Organisational Culture have an influence on the effective process of Knowledge Sharing in business firms. However, there has been a lack of studies carried out to examine the relationship between OC and KS in Information Communication Technology firms generally and in Arabic countries (namely Libya) in particular. Furthermore, there is a dearth of frameworks that assist employees in ICT firms to achieve better practices within KS processes.This study is driven by the need to bridge the gap in the current literature in terms of identifying the nature of the relationship between Organisational Culture and Knowledge Sharing in ICT firms in Libya. As the Information Communication Technology sector in Libya is now heading towards leading the country to a knowledge economy, there is also a need to put forward a framework that helps employees in ICT firms to achieve better practices. This study is undertaken with the aim to “investigate the relationship between Organisational Culture and Knowledge Sharing processes in ICT firms in Libya to enhance Knowledge Sharing practices”. The outcomes from this study are used to develop a framework that will help employees in ICT firms to achieve better practices.This study utilises a mixed research approach. The aim of the study was achieved by adopting the case study research strategy by triangulating the data collected through different techniques (questionnaire, semi-structured interviews and document analysis). Data was collected from four different ICT firms in Libya focusing on the relationship between Organisational Culture and Knowledge Sharing. Descriptive statistics, thematic analysis and content analysis methods were used to analysis the data.The findings from this research suggest that Organisational Culture and Knowledge Sharing are defined, interpreted, and understood differently, so that there is no one specific meaning for either KS or OC. Therefore, there is a need to understand the different meanings and the aspects associated with each concept in order to understand the relationship between both concepts. Furthermore, this study found that OC is influenced by the culture including personal, government, sector, and nation. At the same time, KS is influenced by OC and an organisation’s KS culture rather than by KS as practices or activities. According to the findings of this study, KS in ICT firms in Libya has not been practiced as a way of fulfilling either strategic or organisational practice, rather it has been practiced randomly. In other words, knowledge sharing plans are not formalised within the organisational strategic policies and practices. Therefore, a STEP BY STEP FRAMWORK has been developed with the intention to enhance the practices of KS in ICT firms in Libya which appear to be more retail-customer services’ businesses rather than ICT production service organisations. This fact could suggest that the framework can be applied in other different business contexts, but further investigations would be necessary. The findings of this study have contributed significantly by formulating a framework to enhance KS practices for the ICT firms in developing country as the usage of such framework are limited in countries like Libya

Autoantibodies to Osteoprotegerin are Associated with Low Hip Bone Mineral Density and History of Fractures in Axial Spondyloarthritis: A Cross-Sectional Observational Study

Osteoporosis is a recognised complication of axial spondyloarthritis (axSpA) and is thought to be due to functional impairment and the osteoclast-activating effects of proinflammatory cytokines. The development of autoantibodies to OPG (OPG-Ab) has been associated with severe osteoporosis and increased bone resorption in rheumatoid arthritis. In this study, we screened for the presence of OPG-Ab in axSpA and reviewed their clinical significance. We studied 134 patients, recruited from two centres in the United Kingdom. Their mean age was 47.5 years and 75% were male. Concentrations of OPG-Ab were related to bone mineral density (BMD) and fracture history using linear and logistic regression models adjusting for age, gender, disease duration and activity, body mass index and bisphosphonate use. We detected OPG-Ab in 11/134 patients (8.2%). Femoral neck and total hip BMD were significantly reduced in OPG-Ab positive patients (0.827 vs. 0.967 g/cm2, p = 0.008 and 0.868 vs. 1.028 g/cm2, p = 0.002, respectively). Regression analysis showed that the presence of OPG-Ab was independently associated with total hip osteopenia (ORadj 24.2; 95% CI 2.57, 228) and history of fractures (ORadj 10.5; 95% CI 2.07, 53.3). OPG-Ab concentration was associated with total hip BMD in g/cm2 (ß = −1.15; 95% CI −0.25, −0.04). There were no associations between OPG-Ab concentration and bone turnover markers, but free sRANKL concentrations were lower in OPG-Ab-positive patients (median 0.04 vs. 0.11 pmol/L, p = 0.050). We conclude that OPG-Ab are associated with hip BMD and fractures in axSpA suggesting that they may contribute to the pathogenesis of bone loss in some patients with this condition

Linkages of the 2022 Unprecedented Global Heatwave Events to Triple-Dip La Niña

Heatwaves are influenced significantly by El Niño-Southern Oscillation (ENSO), which alters temperature and precipitation patterns throughout the world. Since 2020, we have witnessed a triple dip La Niña conditions persisting for three consecutive years resulting in severe weather and climate driven events globally. In this study, we identified the dominant frequency of Niño 3.4 Sea Surface Temperature (SST) signals and correlated them with regions experiencing unprecedented heat waves in 2022, namely, the Indian Ocean, the North Atlantic around England and Spain, and the Mediterranean Sea. The signal\u27s power spectrum and its three highest power components are determined based on the signal\u27s Singular Spectrum Analysis (SSA) for each region. Furthermore, the power spectrum coherence (PSC) of Niño 3.4 and other study regions is obtained to determine whether ENSO and heatwaves are linked. We find that Niño 3.4 and the Indian Ocean have the same dominant frequency for the highest power received, indicating ENSO\u27s influence on the Indian heat wave. Additionally, we discovered that in March 2022, the Jet stream is essential in bringing warm Arctic waves southward, passing through Niño 3.4 and India. Furthermore, we found that no other region shared the dominant frequency of the Niño 3.4 region