Antibiotic Prevention of Acute Exacerbations of COPD

An estimated 24 million persons in the United States have COPD on the basis of lung-function testing.1 Globally, COPD is the fourth leading cause of death,2 and in the United States it is the third most common cause of death and chronic complications.3 The average person with COPD has one to two acute exacerbations each year, with wide variation from patient to patient.4 In 2000 in the United States, 726,000 patients were hospitalized with acute exacerbations of COPD.1 During an acute exacerbation, antibiotics are generally administered for 5 to 10 days,5 creating a national burden of 120 million to 480 million antibiotic-days annually. The median hospital stay per exacerbation has been estimated at 9 days.6 In a 2007 Canadian study, the median cost of a hospital stay after an acute exacerbation of COPD was $9,557 (Canadian dollars).7 Acute exacerbations of COPD requiring hospitalization are associated with a 30-day rate of death from any cause of 4 to 30%.6 A study in Sweden showed an all-cause mortality of 26% at 30 days and of 69% at 3 years.8 Acute exacerbations also accelerate the progressive decline in lung function associated with COPD. Overall, the FEV1 falls by approximately 33 ml per year in patients with COPD.4 Each acute exacerbation increases the rate of decline by an additional 2 ml per year4 and by up to 7 ml per year in smokers.

Antihydrogen studies in ALPHA

he ALPHA experiment studies antihydrogen as a means to investigate the symmetry of matter and antimatter. Spectroscopic studies of the anti-atom hold the promise of the most precise direct comparisons of matter and antimatter possible. ALPHA was the first to trap antihydrogen in a magnetic trap, allowing the first ever detection of atomic transitions in an anti-atom. More recently, through stochastic heating, we have also been able to put a new limit on the charge neutrality of antihydrogen. ALPHA is currently preparing to perform the first laser-spectroscopy of antihydrogen, hoping to excite the 2s state using a two-photon transition from the 1s state. We discuss the recent results as well as the key developments that led to these successes and discuss how we are preparing to perform the first laser-spectroscopy. We will also discuss plans to use our novel technique for gravitational tests on antihydrogen for a direct measurement of the sign of the gravitational force on antihydrogen

Pengaruh Celebrity Endorser Dan Iklan Televisi Terhadap Minat Beli Sepeda Motor Yamaha (Study Pada Mahasiswa Fakultas Ekonomi Dan Bisnis Universitas Sam Ratulangi Manado)

Penelitian ini bertujuan untuk menganalisis pengaruh secara simultan variabel celebrity endorser dan iklan televisi terhadap minat beli sepeda motor Yamaha pada mahasiswa Fakultas Ekonomi dan Bisnis Universitas Sam Ratulangi Manado. Jenis penelitian ini merupakan penilitian kuantitatif dengan populasi yaitu seluruh mahasiswa Fakultas Ekonomi dan Bisnis Universitas Sam Ratulangi Manado pengguna motor Yamaha. Sampelnya berjumlah 100 orang responden dengan pengambilan sampel secara purposif dengan kriteria yaitu mahasiswa yang berminat untuk membeli sepeda motor Yamaha ataupun yang memiliki sepeda motor Yamaha. Hasil penelitian ini menunjukan bahwa: 1) Celebrity Endorser dan Iklan Televisi memiliki pengaruh positif dan signifikan terhadap Minat Beli sepeda motor Yamaha pada mahasiswa Fakultas Ekonomi dan Bisnis Universitas Sam Ratulangi Manado. 2) Celebrity Endorser memiliki pengaruh positif dan signifikan terhadap minat beli sepeda motor Yamaha pada mahasiswa Fakultas Ekonomi dan Bisnis Universitas Sam Ratulangi Manado. 3) Iklan Televisi memiliki pengaruh positif dan signifikan terhadap Minat Beli sepeda motor Yamaha pada mahasiswa Fakultas Ekonomi dan Bisnis Universitas Sam Ratulangi Manado

Ionic Tuning of Cobaltites at the Nanoscale

Control of materials through custom design of ionic distributions represents a powerful new approach to develop future technologies ranging from spintronic logic and memory devices to energy storage. Perovskites have shown particular promise for ionic devices due to their high ion mobility and sensitivity to chemical stoichiometry. In this work, we demonstrate a solid-state approach to control of ionic distributions in (La,Sr)CoO$_{3}$ thin films. Depositing a Gd capping layer on the perovskite film, oxygen is controllably extracted from the structure, up-to 0.5 O/u.c. throughout the entire 36 nm thickness. Commensurate with the oxygen extraction, the Co valence state and saturation magnetization show a smooth continuous variation. In contrast, magnetoresistance measurements show no-change in the magnetic anisotropy and a rapid increase in the resistivity over the same range of oxygen stoichiometry. These results suggest significant phase separation, with metallic ferromagnetic regions and oxygen-deficient, insulating, non-ferromagnetic regions, forming percolated networks. Indeed, X-ray diffraction identifies oxygen-vacancy ordering, including transformation to a brownmillerite crystal structure. The unexpected transformation to the brownmillerite phase at ambient temperature is further confirmed by high-resolution scanning transmission electron microscopy which shows significant structural - and correspondingly chemical - phase separation. This work demonstrates room-temperature ionic control of magnetism, electrical resistivity, and crystalline structure in a 36 nm thick film, presenting new opportunities for ionic devices that leverage multiple material functionalities

In situ observation of stress relaxation in epitaxial graphene

Upon cooling, branched line defects develop in epitaxial graphene grown at high temperature on Pt(111) and Ir(111). Using atomically resolved scanning tunneling microscopy we demonstrate that these defects are wrinkles in the graphene layer, i.e. stripes of partially delaminated graphene. With low energy electron microscopy (LEEM) we investigate the wrinkling phenomenon in situ. Upon temperature cycling we observe hysteresis in the appearance and disappearance of the wrinkles. Simultaneously with wrinkle formation a change in bright field imaging intensity of adjacent areas and a shift in the moire spot positions for micro diffraction of such areas takes place. The stress relieved by wrinkle formation results from the mismatch in thermal expansion coefficients of graphene and the substrate. A simple one-dimensional model taking into account the energies related to strain, delamination and bending of graphene is in qualitative agreement with our observations.Comment: Supplementary information: S1: Photo electron emission microscopy and LEEM measurements of rotational domains, STM data of a delaminated bulge around a dislocation. S2: Movie with increasing brightness upon wrinkle formation as in figure 4. v2: Major revision including new experimental dat

Going chiral: overlap versus twisted mass fermions

We compare the behavior of overlap fermions, which are chirally invariant, and of Wilson twisted mass fermions at full twist in the approach to the chiral limit. Our quenched simulations reveal that with both formulations of lattice fermions pion masses of O(250 MeV) can be reached in practical applications. Our comparison is done at a fixed value of the lattice spacing a=0.123 fm. A number of quantities are measured such as hadron masses, pseudoscalar decay constants and quark masses obtained from Ward identities. We also determine the axial vector renormalization constants in the case of overlap fermions.Comment: 22 pages, 10 figure

Alpha Antihydrogen Experiment

ALPHA is an experiment at CERN, whose ultimate goal is to perform a precise test of CPT symmetry with trapped antihydrogen atoms. After reviewing the motivations, we discuss our recent progress toward the initial goal of stable trapping of antihydrogen, with some emphasis on particle detection techniques.Comment: Invited talk presented at the Fifth Meeting on CPT and Lorentz Symmetry, Bloomington, Indiana, June 28-July 2, 201

Variational calculations for the hydrogen-antihydrogen system with a mass-scaled Born-Oppenheimer potential

The problem of proton-antiproton motion in the ${\rm H}$--${\rm \bar{H}}$ system is investigated by means of the variational method. We introduce a modified nuclear interaction through mass-scaling of the Born-Oppenheimer potential. This improved treatment of the interaction includes the nondivergent part of the otherwise divergent adiabatic correction and shows the correct threshold behavior. Using this potential we calculate the vibrational energy levels with angular momentum 0 and 1 and the corresponding nuclear wave functions, as well as the S-wave scattering length. We obtain a full set of all bound states together with a large number of discretized continuum states that might be utilized in variational four-body calculations. The results of our calculations gives an indication of resonance states in the hydrogen-antihydrogen system

Enhancing Web-based Students’ Results and Transcripts Computation in a Hybrid System

An automated computerized examination results management system for tertiary Institution use for end semester examination and generation of transcripts as student’s records processing in a hybrid system is design to overwhelmed the manual or computerized method used for students’ end of semester academic result processing for some institution which was found to be complex and tedium , especially when apply for a large number of students or hybrid system in term of different program. The processing of result in term of grade collection on different courses may involves the entire process time-consuming, error prone and inability to carry out real time control system. The system to be designed is meant to perform student result administration of all facet.  The method to be employ to achieve this approach is top – down hierarchical approach. The expected result show that result and transcript generation was achieved on real time and the monitoring of students with outstanding subject are transfer to a particular partition in the database, where they are monitored on the duration of academic studies before transfer to the first, second and third probations and finally terminated. The system presents a single platform that will be used to manage the processing of all examination records both in part time and full time within the institution. The data used for testing was obtained from the  Department of Academic Planning (DAP) Lagos State Polytechnic, Lagos State. In conclusion, the deployment of academic student processing result and transcripts has demonstrated high sense of efficiency, reliability, error free and real time actualization of student position and good standing. Keywords: End semester Examination, Transcript, Probations. DOI: 10.7176/CEIS/11-1-04 Publication date: January 31st 202

An affordable, quality-assured community-based system for high-resolution entomological surveillance of vector mosquitoes that reflects human malaria infection risk patterns.

ABSTRACT: BACKGROUND: More sensitive and scalable entomological surveillance tools are required to monitor low levels of transmission that are increasingly common across the tropics, particularly where vector control has been successful. A large-scale larviciding programme in urban Dar es Salaam, Tanzania is supported by a community-based (CB) system for trapping adult mosquito densities to monitor programme performance. Methodology An intensive and extensive CB system for routine, longitudinal, programmatic surveillance of malaria vectors and other mosquitoes using the Ifakara Tent Trap (ITT-C) was developed in Urban Dar es Salaam, Tanzania, and validated by comparison with quality assurance (QA) surveys using either ITT-C or human landing catches (HLC), as well as a cross-sectional survey of malaria parasite prevalence in the same housing compounds. RESULTS: Community-based ITT-C had much lower sensitivity per person-night of sampling than HLC (Relative Rate (RR) [95% Confidence Interval (CI)] = 0.079 [0.051, 0.121], P < 0.001 for Anopheles gambiae s.l. and 0.153 [0.137, 0.171], P < 0.001 for Culicines) but only moderately differed from QA surveys with the same trap (0.536 [0.406,0.617], P = 0.001 and 0.747 [0.677,0.824], P < 0.001, for An. gambiae or Culex respectively). Despite the poor sensitivity of the ITT per night of sampling, when CB-ITT was compared with QA-HLC, it proved at least comparably sensitive in absolute terms (171 versus 169 primary vectors caught) and cost-effective (153US$versus 187US$ per An. gambiae caught) because it allowed more spatially extensive and temporally intensive sampling (4284 versus 335 trap nights distributed over 615 versus 240 locations with a mean number of samples per year of 143 versus 141). Despite the very low vectors densities (Annual estimate of about 170 An gambiae s.l bites per person per year), CB-ITT was the only entomological predictor of parasite infection risk (Odds Ratio [95% CI] = 4.43[3.027,7. 454] per An. gambiae or Anopheles funestus caught per night, P =0.0373). Discussion and conclusion CB trapping approaches could be improved with more sensitive traps, but already offer a practical, safe and affordable system for routine programmatic mosquito surveillance and clusters could be distributed across entire countries by adapting the sample submission and quality assurance procedures accordingly