Optimal finite-time processes in stochastic thermodynamics

For a small system like a colloidal particle or a single biomolecule embedded in a heat bath, the optimal protocol of an external control parameter minimizes the mean work required to drive the system from one given equilibrium state to another in a finite time. In general, this optimal protocol obeys an integro-differential equation. Explicite solutions both for a moving laser trap and a time-dependent strength of such a trap show finite jumps of the optimal protocol to be typical both at the beginning and the end of the process.Comment: 4 pages, 1 figure, accepted for publication in Phys. Rev. Let

100%-Biofütterung mit Rapskuchen und heimischen Körnerleguminosen bei der Fütterung von Legehennen verschiedener Herkünfte

Rations of 100% organic and local origin were tested. Up to 18% of thermally proc-essed rape cake was fed in different rations to two groups of laying hens. Faba beans, Vicia sativa and blue lupines were used as protein supplements to create a feeding ration. High vicine and covicine contents, especially in Vicia sativa, led to a refusal of some food rations. No ration has been found suitable for daily use. Chicken fed with a rape cake ration laid eggs with a positive fatty acid pattern, which is favourable for human diets

Ridge Network in Crumpled Paper

The network formed by ridges in a straightened sheet of crumpled paper is studied using a laser profilometer. Square sheets of paper were crumpled into balls, unfolded and their height profile measured. From these profiles the imposed ridges were extracted as networks. Nodes were defined as intersections between ridges, and links as the various ridges connecting the nodes. Many network and spatial properties have been investigated. The tail of the ridge length distribution was found to follow a power-law whereas the shorter ridges followed a log-normal distribution. The degree distribution was found to have an exponentially decaying tail, and the degree correlation was found to be disassortative. The facets created by the ridges and the Voronoi diagram formed by the nodes have also been investigated.Comment: 8 pages, 10 figure, 2 tables Replaced due to wrong formating of author name

Impact of CO2 prices on the design of a highly decarbonised coupled electricity and heating system in Europe

Ambitious targets for renewable energy and CO2 taxation both represent political instruments for decarbonisation of the energy system. We model a high number of coupled electricity and heating systems, where the primary sources of CO2 neutral energy are from variable renewable energy sources (VRES), i.e., wind and solar generators. The model includes hourly dispatch of all technologies for a full year for every country in Europe. In each model run, the amount of renewable energy and the level of CO2 tax are fixed exogenously, while the cost-optimal composition of energy generation, conversion, transmission and storage technologies and the corresponding CO2 emissions are calculated. We show that even for high penetrations of VRES, a significant CO2 tax of more than 100 euro/tCO2 is required to limit the combined CO2 emissions from the sectors to less than 5% of 1990 levels, because curtailment of VRES, combustion of fossil fuels and inefficient conversion technologies are economically favoured despite the presence of abundant VRES. A sufficiently high CO2 tax results in the more efficient use of VRES by means of heat pumps and hot water storage, in particular. We conclude that a renewable energy target on its own is not sufficient; in addition, a CO2 tax is required to decarbonise the electricity and heating sectors and incentivise the least cost combination of flexible and efficient energy conversion and storage.Comment: 20 pages and 9 figures in tota

Evaluation of the therapeutic potential of ant-TLR4-antibody MTS510 in experimental stroke and significa of different routes of application

Toll-like receptors (TLRs) are central sensors for the inflammatory response in ischemia-reperfusion injury. We therefore investigated whether TLR4 inhibition could be used to treat stroke in a standard model of focal cerebral ischemia. Anti-TLR4/MD2-antibody (mAb clone MTS510) blocked TLR4-induced cell activation in vitro, as reported previously. Here, different routes of MTS510 application in vivo were used to study the effects on stroke outcome up to 2d after occlusion of the middle cerebral artery (MCAO) for 45 min in adult male C57Bl/6 wild-type mice. Improved neurological performance, reduced infarct volumes, and reduced brain swelling showed that intravascular application of MTS510 had a protective effect in the model of 45 min MCAO. Evaluation of potential long-term adverse effects of anti-TLR4-mAb-treament revealed no significant deleterious effect on infarct volumes nor neurological deficit after 14d of reperfusion in a mild model of stroke (15 min MCAO). Interestingly, inhibition of TLR4 resulted in an altered adaptive immune response at 48 hours after reperfusion. We conclude that blocking TLR4 by the use of specific mAb is a promising strategy for stroke therapy. However, long-term studies with increased functional sensitivity, larger sampling sizes and use of other species are required before a clinical use could be envisaged

Substrate stiffness and VE-cadherin mechano-transduction coordinate to regulate endothelial monolayer integrity.

The vascular endothelium is subject to diverse mechanical cues that regulate vascular endothelial barrier function. In addition to rigidity sensing through integrin adhesions, mechanical perturbations such as changes in fluid shear stress can also activate force transduction signals at intercellular junctions. This study investigated how extracellular matrix rigidity and intercellular force transduction, activated by vascular endothelial cadherin, coordinate to regulate the integrity of endothelial monolayers. Studies used complementary mechanical measurements of endothelial monolayers grown on patterned substrates of variable stiffness. Specifically perturbing VE-cadherin receptors activated intercellular force transduction signals that increased integrin-dependent cell contractility and disrupted cell-cell and cell-matrix adhesions. Further investigations of the impact of substrate rigidity on force transduction signaling demonstrated how cells integrate extracellular mechanics cues and intercellular force transduction signals, to regulate endothelial integrity and global tissue mechanics. VE-cadherin specific signaling increased focal adhesion remodeling and cell contractility, while sustaining the overall mechanical equilibrium at the mesoscale. Conversely, increased substrate rigidity exacerbates the disruptive effects of intercellular force transduction signals, by increasing heterogeneity in monolayer stress distributions. The results provide new insights into how substrate stiffness and intercellular force transduction coordinate to regulate endothelial monolayer integrity

Antihydrogen studies in ALPHA

he ALPHA experiment studies antihydrogen as a means to investigate the symmetry of matter and antimatter. Spectroscopic studies of the anti-atom hold the promise of the most precise direct comparisons of matter and antimatter possible. ALPHA was the first to trap antihydrogen in a magnetic trap, allowing the first ever detection of atomic transitions in an anti-atom. More recently, through stochastic heating, we have also been able to put a new limit on the charge neutrality of antihydrogen. ALPHA is currently preparing to perform the first laser-spectroscopy of antihydrogen, hoping to excite the 2s state using a two-photon transition from the 1s state. We discuss the recent results as well as the key developments that led to these successes and discuss how we are preparing to perform the first laser-spectroscopy. We will also discuss plans to use our novel technique for gravitational tests on antihydrogen for a direct measurement of the sign of the gravitational force on antihydrogen